49ers vs. Seahawks Prediction & Picks: Tonight's Divisional Round Best Bets
My 49ers vs. Seahawks prediction backs the home favorite in tonight's NFL Divisional Round matchup, as these bitter division rivals meet for the third time this season.
The Seahawks relied on their dominant defense to stifle San Francisco's offense in Week 18, winning 13-3 to secure the division title and the top seed in the conference. Kickoff from Lumen Field in Seattle is scheduled for 8 p.m. ET (FOX), with Seattle entering as a 7-point betting favorite. Letβs dive in as part of our NFL Divisional Round predictions.
π 49ers vs. Seahawks prediction tonight: NFL Divisional Round
See the latest NFL odds and our experts' NFL picks for every game this postseason.
| Predictions | Best odds | Confidence |
|---|---|---|
| Seahawks -7 | -114 via Caesars | ββββ |
| Under 45.5 | -118 via DraftKings | ββββ |
| AJ Barner to score | +170 via bet365 | βββ |
π° 49ers vs. Seahawks best bet: Seahawks -7 (-114) ββββ
Follow all of our NFL analysis and betting advice for the 2026 NFL playoffs.
The absence of George Kittle is colossal here. Kittle would have been critical to making any headway against the league's 10th-ranked passing defense (193.9 yards per contest) and top-ranked scoring defense (17.2 points per game).
One Seahawks weakness is against tight ends, as Seattle has allowed the sixth-most receiving yards to the position. But that'll be difficult to exploit now, and the Seahawks surrendered the second-fewest yards to wide receivers during the regular season.
Our LJ Blut also finds value on the home team in the latest 49ers vs. Seahawks prediction market in the Divisional Round.
Score prediction: Seahawks 24, 49ers 14
π Best 49ers vs. Seahawks touchdown scorer prediction: AJ Barner (+170) βββββ
See all of our NFL touchdown props for the 2026 NFL playoffs.
An otherwise strong 49ers defense (though an injury-riddled one) shares a weak link with the Seahawks. San Francisco also struggles against tight ends, but in a different and more inviting way for this bet.
The Niners are tied for the sixth-most touchdowns allowed to tight ends (10), and they're one of just seven teams during the regular season to finish in double digits. Enter AJ Barner then, who scored six touchdowns this season, two of which came over the final three games. He showed steady hands where it matters most, catching nine of 12 red-zone targets.
We also feature Barner in our NFL anytime touchdown scorer parlay for the Divisional Round, along with all the rest of our 49ers vs. Seahawks player props for this divisional clash.
💰️ 49ers vs. Seahawks expert picks
π 49ers vs. Seahawks odds: NFL Divisional Round
Our live 49ers vs. Seahawks odds update in real time.
π 49ers vs. Seahawks betting trends: NFL Divisional Round
| 49ers | Statistic | Seahawks |
|---|---|---|
| 12-5 | W-L record | 14-3 |
| 12-6 | ATS record | 12-5 |
| 10-8 | O/U record | 9-8 |
| 5.5 | Yards per play | 5.9 |
| 5.6 | Yards allowed per play | 4.6 |
| -6 | Turnover margin | -3 |
| 4-1 | Last 5 games | 5-0 |
π 49ers vs. Seahawks latest injuries
π€οΈ 49ers vs. Seahawks weather: Saturday, 8 p.m. ET
Follow our NFL weather report for the latest forecasts for every playoff game.
The weather shouldn't be a significant factor in this game, as it'll be unseasonably pleasant in the northwest for January. It'll be 43 degrees at kickoff before dropping to 42 by the fourth quarter. The wind will be nearly nonexistent too at 2 mph, and there's a 0% chance of precipitation during what's forecasted to be a clear night in Seattle.
Our Esten McLaren takes a deep dive into the weather for this game with his 49ers vs. Seahawks weather report.
π€ 49ers vs. Seahawks betting splits: NFL Divisional Round
Betting insights via BetMGM.
| Bet type | % of bets | % of handle |
|---|---|---|
| 49ers ML (+260) | 81% | 58% |
| Seahawks ML (-325) | 19% | 42% |
| 49ers +7 | 68% | 59% |
| Seahawks -7 | 32% | 41% |
| Over 45 | 33% | 29% |
| Under 45 | 67% | 71% |
πΊ How to watch 49ers vs. Seahawks: NFL Divisional Round
- Date: Saturday, Jan. 17
- Kickoff: 8 p.m. ET
- Location: Lumen Field (Seattle)
- TV: FOX
π‘ NFL Divisional Round expert picks
- NFL picks against the spread for Divisional Round
- NFL AI predictions for Divisional Round
- NFL weather report for Divisional Round
- NFL playoff QB power rankings for Divisional Round
- NFL upset picks for Divisional Round
- NFL best bets for Divisional Round
- Divisional Round picks to win
- Conference championship look-ahead odds
- Free printable NFL playoff bracket
- NFL playoff bracket predictions
- NFL player props for Divisional Round
- NFL anytime touchdown scorer predictions for Divisional Round
- NFL anytime touchdown scorer parlay for Divisional Round
- NFL long-shot parlay for Divisional Round
- How to live bet the Divisional Round
- NFL first touchdown scorer predictions for Divisional Round
- NFL score predictions for Divisional Round
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