49ers vs. Seahawks Prediction, Picks & Best Bets: NFL Divisional Round
The third clash this season between two fierce division rivals is set for Saturday in the NFL Divisional Round, and we're eyeing the home favorite in our 49ers vs. Seahawks prediction.
This game is in Seattle at Lumen Field because the Seahawks leaned on their dominant defense to suffocate San Francisco's offense in Week 18, winning 13-3 to seal the division title and the top seed in the conference.
The first NFC clash of the Divisional Round begins at 8 p.m. ET, with the Seahawks as the -7 betting odds favorites. Let's dive in as part of our NFL Divisional Round predictions.
🏈 49ers vs. Seahawks prediction: NFL Divisional Round
See the latest NFL odds and our experts' NFL picks for every game this postseason.
| Predictions | Best odds | Confidence |
|---|---|---|
| Seahawks -7 | -114 via Caesars | ⭐⭐⭐⭐ |
| Under 45.5 | -118 via DraftKings | ⭐⭐⭐⭐ |
| AJ Barner to score | +170 via bet365 | ⭐⭐⭐ |
💰 49ers vs. Seahawks best bet: Seahawks -7 (-114) ⭐⭐⭐⭐
Follow all of our NFL analysis and betting advice for the 2026 NFL playoffs.
The absence of George Kittle is colossal here. Kittle would have been critical to making any headway against the league's 10th-ranked passing defense (193.9 yards per contest) and top-ranked scoring defense (17.2 points per game).
One Seahawks weakness is against tight ends, as Seattle has allowed the sixth-most receiving yards to the position. But that'll be difficult to exploit now, and the Seahawks surrendered the second-fewest yards to wide receivers during the regular season.
Elsewhere, our early 49ers vs. Seahawks prediction believes adversity will fuel the Niners.
Score prediction: Seahawks 24, 49ers 14
🙌 Best 49ers vs. Seahawks touchdown scorer prediction: AJ Barner (+170) ⭐⭐⭐⭐⭐
See all of our NFL touchdown props for the 2026 NFL playoffs.
An otherwise strong 49ers defense (though an injury-riddled one) shares a weak link with the Seahawks. San Francisco also struggles against tight ends, but in a different and more inviting way for this bet.
The Niners are tied for the sixth-most touchdowns allowed to tight ends (10), and they're one of just seven teams during the regular season to finish in double digits. Enter AJ Barner then, who scored six touchdowns this season, two of which came over the final three games. He showed steady hands where it matters most, catching nine of 12 red-zone targets.
📊 49ers vs. Seahawks odds: NFL Divisional Round
Our live 49ers vs. Seahawks odds update in real time.
📈 49ers vs. Seahawks betting trends: NFL Divisional Round
| 49ers | Statistic | Seahawks |
|---|---|---|
| 12-5 | W-L record | 14-3 |
| 12-6 | ATS record | 12-5 |
| 10-8 | O/U record | 9-8 |
| 5.5 | Yards per play | 5.9 |
| 5.6 | Yards allowed per play | 4.6 |
| -6 | Turnover margin | -3 |
| 4-1 | Last 5 games | 5-0 |
🚑 49ers vs. Seahawks latest injuries
🌤️ 49ers vs. Seahawks weather: Saturday, 8 p.m. ET
Follow our NFL weather report for the latest forecasts for every playoff game.
The weather shouldn't be a significant factor in this game, as it'll be unseasonably pleasant in the northwest for January. It'll be 43 degrees at kickoff before dropping to 42 by the fourth quarter. The wind will be nearly nonexistent too at 2 mph, and there's a 0% chance of precipitation during what's forecasted to be a clear night in Seattle.
📺 How to watch 49ers vs. Seahawks: NFL Divisional Round
- Date: Saturday, Jan. 17
- Kickoff: 8 p.m. ET
- Location: Lumen Field (Seattle)
- TV: FOX
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