49ers vs. Cardinals Player Props Today: Best Bets & TD Picks

I’m taking a shot with a long shot among my three 49ers vs. Cardinals player props today for the NFC West clash from State Farm Stadium in Glendale, Ariz. (4:05 p.m. ET, Fox).

In addition to an 11-to-1 touchdown scorer prediction, I’m firing off NFL Week 11 predictions on Arizona tight end Trey McBride and San Francisco quarterback Brock Purdy, who returns from a six-week injury absence as a 3-point betting favorite.

✅ 49ers vs. Cardinals player prop bets today

See all of our experts' NFL picks for Week 11.

💰 Best 49ers vs. Cardinals player props

⬇️ Trey McBride player prop: Under 76.5 receiving yards (-111) ⭐⭐⭐⭐⭐

In four games since taking over for Kyler Murray, Arizona quarterback Jacoby Brissett has connected with tight end Trey McBride 32 times for 328 yards. Yet McBride cleared 74 yards just once in those four contests — in fact, he’s done so just once in his past 10 games (last week’s 127-yard effort at Seattle).

Note this, too: Marvin Harrison Jr. was on the field stretching defenses — and thus creating opportunities for McBride — in those 10 games. This week, Harrison is out. That means the 49ers can devote more attention to McBride, whom they held to 43 yards in Week 3. It was the sixth time in seven career games against San Francisco that McBride failed to eclipse 65 yards.

Bet this 49ers vs. Cardinals player prop at Caesars, where the -111 price has a 52.61% implied win probability. Bet $10 to win $9.01.

⬇️ Brock Purdy player prop: Under 256.5 passing yards (-111) ⭐⭐⭐⭐

If you believe 49ers coach Kyle Shanahan, quarterback Brock Purdy is finally returning to the field Sunday. Purdy suffered a turf-toe injury in Week 1, sat out two weeks, returned in Week 4, then shut it down again. Although Mac Jones played well in Purdy’s absence, the offense (allegedly) is back in the hands of the former Mr. Irrelevant.

Suffice to say, I don’t expect Shanahan to put too much on Purdy’s plate this week. Rather, I foresee a lot of handoffs and dump-offs to Christian McCaffrey, which should put Purdy’s passing yards ceiling at 220. Interestingly, three of the last four quarterbacks that faced Arizona — Daniel Jones (212), Jordan Love (179) and Sam Darnold (178) — failed to touch that ceiling. The fourth (Dak Prescott) only got to 250.

DraftKings has the best number on this 49ers vs. Cardinals player prop, with a $10 bet at -111 odds potentially netting $9.01.

6️⃣ Best 49ers vs. Cardinals touchdown scorer bet

🔥 Kyle Juszczyk TD pick: Score anytime touchdown (+1100) ⭐⭐

Just when opponents think 49ers coach Kyle Shanahan is going to zig, he zags. And when they’re convinced Shanahan will zag, he zigs. Which leads me to this 49ers vs. Cardinals touchdown scorer prediction prop on Kyle Juszczyk. Usually, San Francisco’s longtime fullback is the guy leading Christian McCaffrey into the end zone — either by land or by air. Sometimes, though, when all eyes are keyed on CMC, Shanahan will call Juszczyk’s number. 

You know when that last happened? In Week 3, when Juszczyk caught a 1-yard touchdown pass against … Arizona. He also had a scoring reception against the Cardinals in the 2024 finale. In fact, five of Juszczyk’s 19 receiving TDs have come against Arizona. Let’s bet on Shanahan going to the Juszczyk well one more time.

The implied win probability on FanDuel’s juicy +1100 price is 8.33%. Payout on a winning $10 bet: $110.

📊 49ers vs. Cardinals anytime touchdown scorer odds today

See live NFL odds for every game in Week 11.

📺 How to watch 49ers vs. Cardinals

• Date: Sunday, Nov. 16
• Kickoff: 4:05 p.m. ET
• Location: State Farm Stadium (Glendale, Ariz.)
• TV: FOX

💡 NFL expert picks today

Follow all of our NFL analysis for Week 11 throughout the week.

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