🏀 Syracuse vs. UConn Prediction & Picks: Women's March Madness Round 2 (March 23)
Last Updated: March 23, 2026 11:13 AM EDT • 3 minute read X Social Google News Link
The top-seeded UConn Huskies (35-0) will play their final home game of the year when they host the Syracuse Orange at 6 p.m. ET on Monday at Gampel Pavilion in Storrs, Conn., on ESPN.
With the Huskies favored by 35.5 in this women's March Madness Round of 32 battle, I had to get creative with my Syracuse vs. UConn prediction. I'm targeting a first-half team total and a third-quarter spread in a potential blowout based on the latest women's March Madness odds.
🏀 Syracuse vs. UConn picks & odds: Women's March Madness Round 2
See all of our experts' college basketball picks based on the latest college basketball odds; picks rated on a 1-to-5 star confidence scale based on betting value.
| Pick | Best odds | Units | Confidence |
|---|---|---|---|
| UConn 3Q spread -8.5 | -125 via bet365 | 1u -> 0.8u | ⭐⭐⭐⭐ |
| UConn Over 42.5 1H points | -135 via bet365 | 1u -> 0.74u | ⭐⭐⭐⭐ |
Total wagered: 2 units | Max profit: 1.54 units
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🏆 Who will win Syracuse vs. UConn?
UConn hasn't lost a game all year, so I don't expect that to change in this second-round matchup. I'm projecting a 36-point win, as the Huskies can force many turnovers against a young Orange squad. UConn is averaging 15.7 steals per contest this year.
Score prediction: UConn 88, Syracuse 52
💰 Syracuse vs. UConn prediction & best bet
UConn Over 42.5 first-half points (-135)
If you are interested in betting on anything other than the spread or total for this game, bet365 is the only shop offering alternative markets. For my Syracuse vs. UConn prediction, I like the value of the Huskies' first-half team total and the third-quarter spread.
UConn has done an excellent job of getting off to a fast start all year. The Huskies are averaging 45.7 points in the first half this season. Considering the full-game total has climbed from 139 to 140 overnight, I think this is the best way to follow the market.
At the same time, I also like the Huskies' third-quarter spread of -8.5 at bet365, especially if they get off to a slower start than expected. UConn has outscored its opponent by an average of 11.2 points in the third quarter of games this year.
Syracuse's best player is freshman big Uche Izoje. If the Huskies can limit her impact, this game has blowout written all over it.
🚀 Syracuse vs. UConn same-game parlay
While my Syracuse vs. UConn parlay backs the Huskies, neither pick is correlated, so the odds are much better at +210. UConn's scoring breakdown by quarter is as follows: 827 points in the first, 772 in the second, 844 in the third, and 665 in the fourth. The Huskies eventually let off the gas, so I prefer to back them earlier in the game in these lopsided matchups.
💵 Syracuse vs. UConn SGP picks
- UConn first-half Over 42.5
- UConn 3Q spread -8.5
Best odds: +210 via bet365 (0.1u -> 0.21u)
💵 My betting record for college basketball
All college basketball picks, including SGPs, have been tracked since March 13.
| Bet type | Record | Net profit | ROI |
|---|---|---|---|
| Overall | 25-29 | +1.39 units ✅ | 3.9% ✅ |
| Game picks | 13-12 | +0.61 units ✅ | 4.9% ✅ |
| Player props | 9-6 | -0.26 units ❌ | -2.4% ❌ |
| Parlays | 1-10 | -0.51 units ❌ | -31.9% ❌ |
💡 How I'm betting Syracuse vs. UConn: Women's March Madness
Follow all of our college basketball analysis and expert predictions for March Madness.
It can be difficult to find an edge when handicapping such lopsided matchups. Unless you really think the Orange can put up a fight, the main markets are almost an auto-pass for me.
But that's why I find the markets at bet365 so appealing. It's a way to follow the movement on the main markets without needing to sweat the end of this game when reserves are getting minutes.
I don't feel the need to risk more than two units on this matchup, but it's the best way to back an overwhelming Huskies team.
📊 Live Syracuse vs. UConn odds: Women's March Madness Round 2
The total for tonight's Syracuse vs. UConn matchup has climbed from 139 to 140, with DraftKings offering the best value on the Over at 139.5. The spread has been holding steady in the mid-30s.
I'd suspect more action on the Over and UConn before tipoff.
📺 How to watch Syracuse vs. UConn: Women's March Madness Round 2
- Date: Monday, March 23
- Tipoff: 6 p.m. ET
- Location: Gampel Pavilion (Storrs, Conn.)
- TV: ESPN
- Streaming: ESPN App
Shane Thurston X social