Best March Madness Parlay Picks for Final Four Today: Our Best Bet at +527 Odds

With all No. 1 seeds reaching the Final Four in San Antonio, the competition should be fierce during this Saturday’s action at the Alamodome as we make our March Madness parlay picks.

Our picks include a pair of selections against the spread and one on the total as part of this weekend’s March Madness predictions.

While we envision one of the two favorites as a lock to advance, there's an underdog with legs in this year’s Final Four.

🏀 Best March Madness parlay for NCAA Tournament Final Four

Here are my three best March Madness picks for the Final Four of the NCAA Tournament along with the best single-leg and parlay odds from our best sports betting sites.

🚀 Parlay pick #1: Florida -2.5 over Auburn

🗓️ Game info: Saturday, 6:09 p.m. ET (CBS)
📊 Best odds: -108 via DraftKings

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The two best teams in the SEC meet in the Final Four for a right to play for a national championship. Florida beat Auburn in the previous matchup between these two teams, recording an impressive nine-point win on the road at Auburn back in February.

Though the Gators have endured more close shaves throughout their NCAA Tournament run, Florida has been the more consistent team over the past couple of months, losing just once after the first day of February.

Auburn stumbled down the stretch before locking back in during March Madness, but a return to SEC play could show Florida’s superiority. The Gators are a remarkable 27-11 against the spread this season, and they can cover a small spread at a neutral site after having Auburn’s number in its own gym the last time around. 

🚀 Parlay pick #2: Houston +5.5 over Duke

🗓️ Game info: Saturday, 8:49 p.m. ET (CBS)
📊 Best odds: -115 via BetMGM

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We’re holding our breath a bit with this contrarian pick, as it seems the entire world is on Duke against the spread in this matchup. I just can’t get over the consistency of Houston’s competitiveness this season. The Cougars suffered only four losses all campaign, and none came by more than five points.

Houston’s defense is second to none in the nation. That's why I don’t see the Cougars rolling over, even against Duke’s explosive offense. Both Duke and Houston play at slow tempos, which will likely lead to slim margins down the stretch of this game between the two best teams in the country, according to KenPom.

This game should go down to the wire, so if you’re giving me 5.5 points with either side, that’s the side I’m rolling with in this matchup.

🚀 Parlay pick #3: Florida-Auburn Over 159.5

🗓️ Game info: Saturday, 6:09 p.m. ET (CBS)
📊 Best odds: -110 via BetMGM

After Florida and Auburn combined for 171 total points in February, this rematch in the Alamodome only needs to reach 160 points to clear the total. With both teams ranking among the top 11 in the nation in scoring average, the combined average points per game are an eye-popping 168.6.

Both teams play an up-tempo style, with each ranking among the top three nationwide in adjusted offensive efficiency. That's why we can expect to see plenty of up-and-down play.

As long as shooters manage to master the dreaded sightlines that we often hear about in these dome environments, this should be the semifinal game in which the points flow freely.

Games involving Florida have gone 21-17 to the Over, with Auburn contests going 21-16 to the Over this season. 

💰 Best March Madness Final Four parlay

We're combining our three best March Madness picks into a lucrative parlay with +527 odds via Sportsbook, which would turn a $10 bet into a $XX profit if all three teams win in the Final Four of the NCAA Tournament.

🔥 Parlay: Florida (-2.5) + Houston (+5.5) + Florida-Auburn Over 159.5 (+527 via FanDuel)

💰 Wager $10 → Win $52.70

💰 Wager $50 → Win $263.50

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👉 Want to build a bigger parlay or add more bets for your parlay? Use our parlay calculator to find the best odds. Check out our latest college basketball picks and the rest of our March Madness first-round picks.

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👑 Best March Madness betting sites

Ready to place your March Madness bets? Check out the best March Madness betting promos from our best March Madness betting sites, as determined by our expert team at Sportsbook Review.

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