March Madness Final Four AI Predictions Today: Who Does ChatGPT Pick to Win Auburn-Florida & Duke-Houston?

We've reached the final weekend of March Madness, and our AI bracket predictions have held up well through all of today's chaos (or lack thereof). But can our Final Four AI predictions find the same success in the NCAA Tournament semifinals?

Duke and Florida are the favorites to advance by the latest March Madness odds in a potentially all-time weekend with all four No. 1 seeds advancing to the Final Four in San Antonio. We've turned to ChatGPT to offer its predictions, best bets, and exact score for both semifinal games on Saturday.

👉 Need help with your bets? Check out all of our March Madness Final four expert picks.

🤖 Final Four AI predictions & best bets

Our AI-generated projections for the Final Four were generated using the ChatGPT 4o model - which relied on probabilistic modeling to generate its exact score projections, best bets, and top player prop for each NCAA Tournament Final Four matchup on Saturday.

The baseline model has been trained on decades of NCAA Tournament data, but we also trained it using 2025 team metrics for all four finalists including:

• Adjusted offensive + defensive ratings
• Tempo
• Luck factor
• Strength of schedule
• NET rating differential

To be clear: ChatGPT is a large language model and not specifically designed for predicting sporting events, so these should be viewed as primarily entertainment. That said, the AI model can often spot trends or insights that bettors might overlook.

📊 NCAA Tournament betting lines: March Madness odds | Final Four odds & predictions

🏀 Auburn vs. Florida AI prediction, picks & player prop bets

📅 Date: Saturday, April 5
🕖 Time: 6:09 p.m. ET
📍 Location: San Antonio
📺 TV: CBS
📊 Odds: Florida -2.5 | O/U 153.5

🎯 AI score prediction: Florida 80, Auburn 74

✅ ATS pick: Florida -2.5 (-108 via DraftKings)
✅ ML pick: Florida (-148 via DraftKings)
✅ O/U pick: Under 160 (-110 via Caesars)

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🔍 Who will win Auburn vs. Florida?

Florida owns the No. 2 offensive rating (129.1) and plays at a faster pace than Auburn. Auburn’s No. 8 defense (92.4) keeps this close, but Florida's balance, superior efficiency, and current form give it the edge in a high-possession game. The Gators’ luck factor is slightly negative, suggesting their performance may be underrated relative to their record.

🔥 Best player prop bet: Walter Clayton Jr. Over 20.5 points

📊 Best odds: -115 via BetMGM
🤖 AI projection: 21.7 points

Clayton has averaged 22.3 PPG in the NCAA Tournament and faces an Auburn team that struggles to keep opponents from getting to the free-throw line, where Clayton excels. Given Florida’s tempo and Clayton's usage rate, he should surpass this number for the fourth time in five games in a fast-paced matchup.

🏀 Duke vs. Houston AI prediction, picks & player prop bets

📅 Date: Saturday, April 5
🕖 Time: 8:49 p.m. ET
📍 Location: San Antonio
📺 TV: CBS
📊 Odds: Duke -5 | O/U 136.5

🎯 AI score prediction: Duke 72, Houston 66

✅ ATS pick: Duke -5 (-110 via bet365)
✅ ML pick: Duke (-250 via FanDuel)
✅ O/U pick: Over 136.5 (-110 via Caesars)

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🔍 Who will win Duke vs. Houston?

This is a classic elite offense vs. elite defense battle, as Duke’s No. 1 offense (130.1) meets Houston’s No. 1 defense (87.4). Duke also owns the highest net rating in the country (+39.63) and boasts a deeper offensive bench. Houston slows its pace to a crawl, which keeps the game lower-scoring. But Duke’s tempo edge and overall efficiency push the Blue Devils past the Cougars in the final minutes.

🔥 Best player prop bet: Cooper Flagg Over 7.5 rebounds

📊 Best odds: -135 via BetMGM
🤖 AI projection: 10.1 rebounds

Flagg should thrive against a Houston team that struggles on the defensive glass due to its lack of size and conservative approach. Flagg is averaging 7.8 rebounds in the NCAA Tournament, and his length gives him a clear edge in this Final Four matchup.

🔮 NCAA Tournament championship look-ahead lines

If our AI model plays out correctly, expect a thrilling Duke vs. Florida matchup in Monday’s national championship game in San Antonio. We broke down that potential matchup in our March Madness look-ahead odds, which you can bet at FanDuel for every hypothetical matchup entering the Final Four.

🏀 Can't get enough March Madness? Check out our March Madness MVP predictions and our March Madness Final Four survivor pool picks.

🆚 Final Four game predictions

• Auburn vs. Florida prediction
• Auburn vs. Florida player props
• Auburn vs. Florida parlay
• Duke vs. Houston prediction
• Duke vs. Houston player props
• Duke vs. Houston parlay

🏀 Best March Madness odds, predictions & expert picks for Final Four

• Final Four odds & predictions
• March Madness MVP predictions
• March Madness odds entering Final Four
• March Madness Final Four survivor pool picks
• March Madness look-ahead odds
• March Madness AI predictions for Final Four
• Best March Madness parlay picks for Final Four
• Final Four best players
• Would 2024 UConn beat any Final Four teams?

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