⚾ Yankees vs. Giants Prediction & Picks: MLB Odds for Opening Night, March 25

The 2026 MLB season kicks off with Opening Night on Wednesday, as the New York Yankees visit the San Francisco Giants at 8:05 p.m. ET (Netflix) at Oracle Park.

Multiple players involved in this one are fresh off Team USA's disappointing World Baseball Classic result, including Giants starting pitcher Logan Webb. Taking the hill for the visitors is Max Fried, and our Yankees vs. Giants prediction looks at whether we can expect a lower-scoring game when these two Cy Young candidates square off.

The Yankees are small betting favorites, but I'm expecting a longtime rival to once again punish New York fans on Opening Night.

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⚾ Yankees vs. Giants picks & odds today

See all of our experts’ MLB picks based on the latest MLB odds; picks rated on a 1-to-5 star confidence scale based on betting value.

Total wagered: 2.33 units | Max profit: 3.7 units

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🏆 Who will win Yankees vs. Giants?

Contrary to what you might assume from a game featuring Cy Young contenders, I expect this to feature plenty of scoring. The game total is set at 7, but I anticipate double-digit runs. I like the look of this Giants lineup, and though things didn't go as planned during the second half of the 2025 season, I'm backing them to start this campaign with a W.

Score prediction: Giants 7, Yankees 5

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💰 Yankees vs. Giants prediction & best bet

Giants moneyline (+104)

In this battle of aces, I'll take Webb. He'll frustrate this Yankees lineup while his offense gets active against Fried, and the Giants should have a relatively significant lead when he exits. He got in a solid preseason workload between spring training and the WBC, and he'll be sharp on Wednesday night as a result.

The Giants' bullpen is sketchier than it was last year with Randy Rodriguez injured, Tyler Rogers in Toronto, and Camilo Doval pitching for the Yankees. However, Webb and the offense will give the bullpen enough of a cushion to hold on for the win.

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🔥 Best Yankees vs. Giants player prop bet

Rafael Devers Over 1.5 H+R+RBI (+111)

I don't need to tell Yankees fans this (or fellow Boston Red Sox ones), but for those who don't know, Rafael Devers is the King of New York.

He has an .880 OPS for his career against the Yankees, and his 31 homers are the most he's hit against any team. Last season, before the Red Sox traded him, he had three homers in six games against New York, with five runs scored and four RBIs total. And one of those homers came against ... you guessed it, Fried.

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💣 Yankees vs. Giants home run prediction

Ben Rice to hit a home run (+470)

Many Yankees racked up homers last year thanks to their generous ballpark. Trent Grisham had 34 homers to 27.9 expected home runs, Jazz Chisholm had 32 to 28.9, and Cody Bellinger had 30 to 28.1. However, Ben Rice actually had more xHR than long balls.

Rice absolutely annihilated the baseball in 2025. He had a 95th percentile average exit velocity, 92nd percentile barrel rate, and his 56.1% hard-hit rate was among the very best in baseball.

Oracle Park is a pitchers' park, so if someone is going to get one out, it'll need to be a nuke. Rice is the best bet when it comes to his profile and these odds.

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🚀 Yankees vs. Giants same-game parlay

I'm parlaying the Giants to win with this game going Over 7 runs, and I'm adding Devers and Rice hitting props for my Yankees vs. Giants SGP at DraftKings. As you can see, the odds are relatively long, so be sure to limit your wager size.

💵 Yankees vs. Giants SGP picks

• Giants moneyline (-101)
• Over 7 (-105)
• Rafael Devers 1+ hits (-161)
• Ben Rice 1+ hits (-195)

Best odds: +575 via DraftKings (0.2u -> 1.35u)

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💵 My betting record for MLB picks

With the MLB season yet to begin, these are my first bets. But here is my betting record for the 2026 WBC.

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💡 How I'm betting Yankees vs. Giants: MLB strategy

Follow all of our MLB analysis and expert predictions for baseball season.

Since it's the first game of the season, I don't want to rain on anyone's parade. I personally don't love the idea of slamming a full unit on a moneyline the day before a game when we have nothing but 2025 stats to go off, but I also see why it's enticing to do so.

Here's what I'd do: I'd take the moneyline, game total (I like the Over 7), and Devers prop and split a unit between the three, or pick one to bet on alone. Then, I'd put 0.33 units on the Rice home run prop.

I think home run props are actually going to be my most profitable betting market this year, so that's what I'd prioritize in this game, along with the Devers prop. I think the Giants should win, but again, we don't have a ton of information to support that.

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📊 Live Yankees vs. Giants odds

As of 9:30 a.m. on Tuesday morning, bettors at DraftKings are all over the Yankees, so I'm going against the public with my moneyline pick. Around 81% of moneyline bets are on the Yankees, while 78% of run line bets are on the favorites to cover the -1.5 spread. However, bettors are far more split on the total, as 54% at DraftKings are taking the Over.

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📈 Yankees vs. Giants betting trends

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🚑 Yankees vs. Giants injuries

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📺 How to watch Yankees vs. Giants

• Date: Wednesday, March 25
• First pitch: 8.05 p.m. ET
• Ballpark: Oracle Park (San Francisco)
• Streaming: Netflix