Guardians vs. Royals Prediction, Odds & Best Bets: Will Ramirez Continue Hot Streak?

Last Updated: July 25, 2025 8:50 AM EDT • 4 minute read X Social Google News Link

Two American League Central division rivals begin their third head-to-head series of the season as the Kansas City Royals (50-53) host the Cleveland Guardians (51-51) from Kauffman Stadium, with first pitch set for 8:10 p.m. ET (Apple TV+). Kansas City enjoys a rest advantage having an off day yesterday while Cleveland was in action, but we analyze whether that impacts our Guardians vs. Royals prediction.
We also include a player prop in our Guardians vs. Royals best bets, and have targeted arguably the best hitter in the series in Jose Ramirez.
- Guardians vs. Royals prediction: Guardians to win (-102 via FanDuel) ⭐⭐⭐
- Best Guardians vs. Royals player props: Jose Ramirez Over 1.5 total bases (-105 via DraftKings) ⭐⭐⭐
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✅ Guardians vs. Royals prediction: Guardians to win (-102 via FanDuel)
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Cleveland failed to complete a four-game sweep of the Baltimore Orioles in yesterday’s 4-3 loss, but its hot play of late has me backing the road underdogs as my Guardians vs. Royals prediction.
Prior to yesterday’s loss, the Guardians had won 11 of 13 games, which followed a 10-game losing streak. The hot streak had Cleveland over .500 for the first time since June 26 when it was 40-39. Thus, this series could be integral in the team’s decision-making heading into next week’s trade deadline.
While Cleveland has gotten its usual stellar production from Jose Ramirez of late, its contributions from others in the lineup were a big reason it entered yesterday second in runs per game (6.2) since the All-Star break. In particular, less-heralded sluggers like Angel Martinez and Kyle Manzardo were each slugging .528 or better since June 18.
The Royals enjoyed a day off yesterday, but are just 7-7 following an off day, and 1-1 when they have the rest advantage over their opponents. I trust more in Cleveland’s play of late, and the fact it is a profitable 17-17 as road ‘dogs this year, while winning four of the six matchups to this point against Kansas City, as my Guardians vs. Royals best bet.
FanDuel is the only best sports betting site where one can back Cleveland at less than -105 odds. A winning $10 wager would pay out $9.80 in profits.
💰 Best Guardians vs. Royals player props
✅ Best Guardians vs. Royals player prop: Jose Ramirez Over 1.5 total bases (-105 via DraftKings)
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Jose Ramirez went over this projected total yesterday with two hits in his first two at-bats. That extended a hot streak in which he hit eight home runs, drove in 18 runs, stole nine bases, and slugged .789 in 16 games prior to that since July 4.
Despite Ramirez going 4-for-16 in his career against Royals righty Michael Wacha, I am backing him with my best Guardians vs. Royals player prop.
Ramirez is batting .300 in road games this year, and his .854 career OPS against Kansas City is his second-highest against AL Central opponents. He has gone over this projected total in six of the previous seven games, which makes the -105 odds DraftKings offers for the Over seem like a steal. FanDuel is on the high end of the market with the Over juiced to -115 (carrying a 53.49% implied probability).
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Mike Spector X social