Guardians vs. Red Sox Prediction, Odds & Expert Picks Tonight: MLB Best Bets for Sept. 2
My Guardians vs. Red Sox prediction backs the host team, as Boston has won seven of its last 10 home games and is a -250 moneyline favorite tonight. First pitch is scheduled for 6:45 p.m. ET from Fenway Park in Boston.
On top of their recent form at home, Boston has ace Garrett Crochet on the mound tonight. I'm backing one of his player props in addition to the Red Sox as part of my MLB picks tonight.
⚾ Guardians vs. Red Sox expert picks & predictions
MLB expert picks made Tuesday; odds subject to change.
- Moneyline pick: Red Sox (-250 via BetMGM) ⭐⭐
- Run line pick: Red Sox -1.5 (-115 via BetMGM) ⭐⭐⭐
- Over/Under pick: Over 8 (-114 via FanDuel) ⭐⭐⭐
📝 Guardians vs. Red Sox preview & best bet
Track the latest MLB scores for line movement and matchup info.
🧦 Red Sox -1.5 (-115) ⭐⭐⭐
The Red Sox took the series opener on Monday night, holding off the Guardians for a 6-4 victory. Boston has been excellent at the friendly confines of Fenway Park this season, registering a 43-27 record. They are top 10 in batting average and OPS at home in 2025.
The Red Sox are also above average in a number of offensive categories against right-handed pitching. Guardians right-hander Slade Cecconi has been good on the road this season, but struggled in August, going winless in five starts with a 6.31 ERA and .294 opponents’ batting average. Cecconi’s 5.61 expected ERA is over a run higher than his actual mark of 4.41, and most of his peripheral stats indicate he’s benefited from some good fortune this season.
One of the best betting sites, betMGM, offered the Red Sox at -1.5 on the runline at -115 odds, which nets out a $8.70 profit on a $10 bet. The -115 odds have an implied probability of 53.49%.
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💰 Best Guardians vs. Red Sox player prop bet
Our MLB player prop odds tool shows the best odds for every market across legal sportsbooks in your area.
🔥Garrett Crochet Over 16.5 outs recorded (-120) ⭐⭐⭐
Garrett Crochet has overpowered opponents all season long, and is a legitimate candidate to win his first career Cy Young.
The dominant left-hander completed seven innings in three of his five starts in August, setting up nicely against a Guardians lineup that ranks 29th in the league in OPS (.660) and 28th in wRC+ (84) in 2025. The Guardians own the league’s worst batting average at .223 and strike out nearly 23% of the time. It could be a long evening for Cleveland’s hitters against Crochet.
A $10 bet on Crochet’s over nets out a profit of $8.33 at DraftKings, one of the best sports betting sites. The -120 odds have an implied probability of 54.55%.
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📊 Guardians vs. Red Sox odds: Sept. 2
MLB odds update live in real time.
📈 Guardians vs. Red Sox betting odds analysis
Boston opened as -250 favorites with some of the best sports betting sites having them as high as -275 on the moneyline. I think the better target is the spread, as this game profiles as a major mismatch between two teams heading in different directions.
👀 Guardians vs. Red Sox betting odds update
The odds have gotten slightly worse on our Red Sox -1.5 pick, which now has -125 odds at the best sports betting sites. The market is clearly confident in Boston tonight, as its moneyline odds have lengthened from -250 to -275.
🔢 Guardians vs. Red Sox stats
Season stats courtesy of baseball-reference.com.
| Guardians (68-68) | Statistic (per game) | Red Sox (77-62) |
|---|---|---|
| 3.85 | Runs | 4.92 |
| 7.27 | Hits | 8.68 |
| .223 | AVG | .253 |
| .366 | SLG | .425 |
| .660 | OPS | .750 |
| 3.94 | ERA | 3.69 |
| 8.40 | K/9 | 8.34 |
| 3.54 | BB/9 | 3.32 |
| 1.12 | HR/9 | 1.01 |
🚑 Guardians vs. Red Sox injuries
📺 Guardians vs. Red Sox game info
- When: Tuesday, Sept. 2
- First pitch: 6:45 p.m. ET
- Where: Fenway Park (Boston)
- How to watch: Local TV
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❓ Guardians vs. Red Sox FAQs
Who is favored to win Guardians vs. Red Sox?
The Red Sox are -250 home favorites to defeat the Guardians on Tuesday.
What is the run line for Guardians vs. Red Sox?
Boston is a -1.5 run line favorite against Cleveland in Monday’s matchup.
What is the Over/Under for Guardians vs. Red Sox?
The total for Tuesday’s game between the Guardians and Red Sox is 8.
What are the best bets for Guardians vs. Red Sox?
My best bets for Tuesday’s Guardians vs. Red Sox game are Boston -1.5 (-115) and Garrett Crochet Over 16.5 outs (-120).
When is the Guardians vs. Red Sox game?
First pitch is set for 6:45 p.m. ET on Tuesday at Fenway Park.
How do baseball odds work?
When betting on MLB, the run line shows how many runs the favorite needs to win by in order to cash the bet. For example, a favorite of -1.5 must win by two or more runs to cover the run line, while an underdog at +1.5 must win outright or lose by one run to cover the run line.
Moneyline odds represent the payout for picking the outright winner (+200 means a $100 bet wins $200, while -200 means a $200 bet wins $100). Over/Unders let you wager on whether the combined total of runs will be higher or lower than the set number.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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