Dodgers vs. Angels Predictions, Odds & Best Bets: Ohtani Set to Plow Through Angels' Lineup

Shohei Ohtani's return to the mound continues tonight against an Angels offense that leads MLB in strikeouts.
Dodgers vs. Angels predictions
Pictured: Los Angeles Dodgers starting pitcher Shohei Ohtani throws a pitch as we look at our Dodgers vs. Angels prediction. Photo by: Darren Yamashita / Imagn.

The time has come yet again to marvel at an athletic feat that has no business happening at the level Shohei Ohtani does it, and we're not above being wide-eyed while making our Dodgers vs. Angels predictions.

Ohtani takes to the mound for the ninth time this season. He's been eased back gradually post-injury, but another season-high in pitches could come tonight against a team that's done the strikeout walk of shame more than any other.

That's why Ohtani features prominently in our Dodgers vs. Angels best bets ahead of first pitch at 9:38 p.m. ET from Angel Stadium (MLB Network), and why the Dodgers are the overwhelming -200 moneyline favorites at our best sports betting sites.

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✅ Dodgers vs. Angels prediction: Dodgers -1.5 (-126 via FanDuel)

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It can be difficult to get a read on the 2025 version of the Dodgers lately.

Often they look like the steamrolling defending champs we've come to know. They still hold a sizable lead atop the World Series odds and sit fourth in the NL.

But there's also a reason why their lead in the NL West has been evaporating, and the Dodgers are now tied with the San Diego Padres atop the division after losing three straight games, including the first two of this series to the lowly Angels.

And that plunge is mostly tied to pitching, and a staff that sits 19th MLB-wide with its 4.15 ERA. That gets a little worse when focusing on a limping bullpen that sits 21st (4.21).

Which is all concerning at first as we make our Dodgers vs. Angels prediction, until you remember that a baseball experiment is on the mound for the Dodgers today.

Yes, Ohtani may be on the mound for a shorter time than if he was at his full workload, though he set a season high in both pitches (54) and innings (four) during his last outing. The Dodgers are understandably taking a cautious approach, but it's feasible that he's stretched just a little further and lasts five innings.

That gives a potent Dodgers offense plenty of time to do damage against an even worse Angels staff that ranks 27th (4.85 ERA). Offense certainly hasn't been an issue for a team that sits among the top two in runs, home runs, slugging percentage, and OPS. That includes in this series against the Angels, with the Dodgers scoring 10 runs over the first two games.

Bet sure to make this Dodgers vs. Angels best bet at FanDuel, as it provides a slight edge on the run line over several of our other best MLB betting sites that are offering -130.

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💰 Best Dodgers vs. Angels player prop

✅ Best Dodgers vs. Angels player prop: Ohtani Over 5.5 strikeouts (-115 via DraftKings)

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Ohtani has shown he doesn't need a significant workload to top this number, which was especially true in his last outing when he required only four innings to record eight strikeouts.

That came against the St. Louis Cardinals, who excel at minimizing strikeouts and have recorded the eighth-fewest leaguewide. The Angels? They're miles away on the opposite end of the spectrum, which is key as we make our best Dodgers vs. Angels player props pick.

The Angels have struck out the most in MLB at 1,161. For perspective, the Colorado Rockies are unsurprisingly not far behind (1,125), but then it's a steep drop to the Boston Red Sox (1,078).

The Halos trot out an astounding five regulars whose strikeout rates rest at 25% or higher, two of whom sit in the bottom 5% leaguewide (Logan O'Hoppe and Mike Trout). That makes for a mouthwatering matchup for the MLB MVP odds NL leader, even on a reduced workload. He's producing an 11.8 K/9, mostly through his always intimidating fastball with its velocity that registers in the 98th percentile.

Elsewhere, our Gabe Henderson believes in his best home run predictions today that the lab creation known as Ohtani can go deep tonight, too.

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