Blue Jays vs. Tigers Prediction, Odds & Best Bets: Can Skubal Turn Things Around For Detroit?

Last Updated: July 26, 2025 12:19 PM EDT • 4 minute read X Social Google News Link

The Toronto Blue Jays (62-42) have steamrolled their way to the best record in the American League, including two dominant wins in this series against the Detroit Tigers (60-45). Our Blue Jays vs. Tigers prediction analyzes whether Toronto’s winning streak will continue against baseball's best pitcher.
Our Blue Jays vs. Tigers best bets makes our best batter prop wager on Vladimir Guerrero Jr., knowing he is facing AL Cy Young odds favorite Tarik Skubal. First pitch from Comerica Park is set for 6:10 p.m. ET.
- Blue Jays vs. Tigers prediction: Tigers to win (-190 via bet365) ⭐⭐⭐⭐⭐
- Best Blue Jays vs. Tigers player props: Vladimir Guerrero Jr. Over 1.5 total bases (+170 via bet365) ⭐⭐⭐
⚾ Blue Jays vs. Tigers prediction & odds
🔎 Our NEW MLB player prop odds tool can help you find the best MLB odds to make your MLB picks.
📊 Live Blue Jays vs. Tigers odds
💰 Blue Jays vs. Tigers prediction & best bet
✅ Blue Jays vs. Tigers prediction: Tigers moneyline (-190 via bet365)
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
It is fair to wonder if the Tigers got complacent building the only double-digit game lead in any division. However, despite their recent struggles, the one constant remains Skubal, and he is the biggest reason for backing Detroit with my Blue Jays vs. Tigers prediction.
Toronto entered this series winning 16 of 20 games, while averaging 5.7 runs per game, owning a plus-38 run differential, and its bullpen pitching to a 2.58 ERA. Meanwhile, the Tigers entered having gone 1-9 in their prior 10 games while scoring 2.6 runs per game, batting .209 as a team, owning a minus-40 run differential, and pitching to a 6.67 ERA.
Even though the Tigers have now lost 11 of 12, their lone win in that span was a Skubal masterpiece on Sunday Night Baseball last week, when he struck out 11 over 6 2/3 innings and allowed just one run.
While Toronto’s 17-10 record against southpaws this season is tied for second-best in the AL, I expect the Cy Young favorite to help end Toronto’s 12-game winning streak as an underdog as my Blue Jays vs. Tigers best bet.
Detroit is as high as a -201 moneyline favorite at DraftKings, so the best value is at bet365, where a $10 winning wager at -190 odds would net $5.26 in profit.
💰 Best Blue Jays vs. Tigers player props
✅ Best Blue Jays vs. Tigers player prop: Vladimir Guerrero Jr. Over 1.5 total bases (+170 via bet365)
Guerrero entered Friday’s game slashing .550/.609/.800 with a 1.409 OPS, six RBIs, and seven runs in the last five games. All he did to follow that up was hit two more doubles, score two runs, and drive in another in yesterday’s 6-2 win.
Albeit in a small sample size, Guerrero has two hits in three at-bats against Skubal, including a home run. I am eschewing Guerrero's standard O/U of 0.5 total bases (the Over is juiced as high as -190) in favor of his alternate total bases line as my best Blue Jays vs. Tigers player prop.
Teams likely have no choice but to pitch to Guerrero, given the protection he has received from Bo Bichette. Bichette extended his hitting streak to seven games, and has now hit safely in 27 of his last 31 games.
That makes Guerrero’s +170 odds at bet365 appealing, especially since they are as low as an even money +100 at FanDuel. Thus, this is great value for him to go over this projected total for the sixth time in the last seven games.
💡 Expert MLB predictions today
- Home run predictions today
- Phillies vs. Yankees prediction
- Guardians vs. Royals prediction
- Blue Jays vs. Tigers prediction
- Dodgers vs. Red Sox prediction
❓MLB betting FAQs
How do betting odds work?
Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.
What is the run line in baseball?
The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.
What does moneyline mean in betting?
The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.
💵 Best MLB betting sites
Want to bet on Blue Jays vs. Tigers? Check out the best MLB betting sites and best sportsbook promos for today's MLB games:
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
- Hard Rock Bet Promo Code | Read our Hard Rock Bet Review
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Mike Spector X social