Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets for Sept. 26

Last Updated: September 26, 2025 7:57 AM EDT • 4 minute read X Social Google News Link

The final weekend of the MLB regular season is upon us, as sluggers around the league have their last chances to add to their gaudy home run totals. The focus of my best home run predictions today is overlooked Atlanta Braves slugger Ronald Acuna Jr., who has performed admirably when healthy.
Joining Acuna in my four-pack of home run MLB picks are Willy Adames, Alex Bregman, and Christian Walker.
If Acuna, Adames, Bregman, and Walker all homer, my four-leg $10 parlay would net nearly $6,000 in profits.
💰 MLB best home run predictions & odds today: Sept. 26
Best home run predictions today based on the latest MLB odds.
🧨 Alex Bregman to
hit a home run (+500 via FanDuel) ⭐⭐
🧨 Ronald Acuna Jr.
to hit a home run (+356 via DraftKings) ⭐⭐⭐
🧨 Christian Walker
to hit a home run (+332 via DraftKings) ⭐⭐⭐
🧨 Willy Adames to
hit a home run (+440 via FanDuel) ⭐⭐
💣 Best home run prediction today: MLB expert picks & prop bets
Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.
⚾ Ronald Acuna Jr. (Braves) to hit a home run ⭐⭐⭐

Ronald Acuna Jr. has 20 home runs in 92 games this year, which would extrapolate to 35 home runs over a full season. He is in midseason form in September with five home runs (all within the last 15 days) and a .900 OPS. He has also belted three home runs this week alone, adding to an eye-popping 1.214 OPS.
Acuna has great career numbers against Pirates righty Mitch Keller, going 7-for-18 with three bombs. He should again provide outstanding protection for teammate Matt Olson in the lineup, as those two are the only batters in tonight’s lineup with a 1.145 OPS or better in their careers against Keller (min. 10 AB).
Pittsburgh is 1-6 in Keller’s last seven starts, with the righty allowing at least one home run in six straight. He has followed up a 6.52 ERA in August with a 4.32 ERA through three September starts, which is on pace to be two of his worst three months of the season.
With Keller seemingly wearing down over the final stretch, Acuna’s 22.73% implied odds to hit a home run on the high end of the market seem like a steal. DraftKings provides the best value on this wager, as a $10 bet would net $35.60 in profits if the slugger homers for the third time in the last four games.
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📊 Pirates vs. Braves odds
🚀 Best home run parlay picks
Use our parlay calculator to get the best odds for any parlay.
💣 Alex Bregman to hit a home run (+500 via
FanDuel)
💣 Ronald Acuna Jr. to hit a home run (+340 via FanDuel)
💣 Christian Walker to hit a home run (+320 via FanDuel)
💣 Willy Adames to hit a home run (+440 via FanDuel)
Parlay odds: +59775 via FanDuel ($10 to win $5,977.52)
❓ Best home run predictions FAQs
What are the best home run props for tonight?
My best home run predictions today feature Alex Bregman, Ronald Acuna Jr., Christian Walker, and Willy Adames.
What is a home run bet?
A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.
Can you parlay home run bets?
Yes, you can parlay home run bets. We've provided our best home run parlay today.
How do I place a home run bet?
To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.
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Mike Spector X social