Best Home Run Predictions Today: MLB Odds, Picks & Prop Bets Tonight for Sept. 23

Though there were just seven home runs on Monday, we hit on one of them with Ronald Acuna Jr.’s blast at +410 odds, turning in a profitable day. Let’s keep the momentum going with our best home run predictions today.

There is arguably no bigger matchup in the National League than the series opener between the Los Angeles Dodgers and Arizona Diamondbacks, and I focus on a Dodgers slugger with great career numbers against tonight’s starting pitcher. 

Joining Mookie Betts in my four-pack of MLB picks are Bryce Harper, Aaron Judge and Isaac Paredes. If all four homer, my four-leg $10 parlay would net nearly $5,000 in profits.

💰 MLB best home run predictions & odds today: Sept. 23

Best home run predictions today based on the latest MLB odds.

• Bryce Harper to hit a home run (+340 via FanDuel) ⭐⭐
• Aaron Judge to hit a home run (+240 via FanDuel) ⭐⭐⭐
• Mookie Betts to hit a home run (+525 via DraftKings) ⭐⭐⭐
• Isaac Paredes to hit a home run (+440 via FanDuel) ⭐⭐

💣 Best home run prediction today: MLB expert picks & prop bets

Here is my favorite MLB home run bet today and analysis of why it leads my MLB home run predictions.

⚾ Mookie Betts (Dodgers) to hit a home run ⭐⭐⭐

Betts is one of two Dodgers (Ohtani) ranked in the top eight in ISO in September (min. 50 PA). Amid that power surge, he has displayed his usual outstanding contact, as his 10.5% strikeout rate is the lowest among the top 24 sluggers in that metric.

Betts ranks 11th in hard contact in September, and his 48.6% hard-hit rate this month is better than some of the sport’s most prolific home run hitters like Shohei Ohtani, Kyle Schwarber, and Juan Soto.

The Dodgers shortstop is 7-for-17 with two home runs in his career off Diamondbacks righty Brandon Pfaadt. Pfaadt has allowed three home runs in 16 ⅔ innings against the Dodgers this year and is one of 25 pitchers to allow at least 24 home runs this season.

Betts has hit 10 home runs in his career at Chase Field, tied for the second-most in any visiting ballpark. He is slashing .368/.350/.526 in Arizona’s home stadium this year, and he has a great chance to do damage against a pitcher that the Dodgers pounded for four earned runs on eight hits over 4 ⅓ innings at the end of August. 

Betts has as high as a 16.67% implied probability to homer tonight, but the best payout is through DraftKings’ +525 odds. There, a $10 winning wager would net $52.50 in profits if the Dodgers slugger goes yard.

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📊 Dodgers vs. Diamondbacks odds

🚀 Best home run parlay picks

Use our parlay calculator to get the best odds for any parlay.

• Bryce Harper to hit a home run (+340 via FanDuel)
• Aaron Judge to hit a home run (+240 via FanDuel)
• Mookie Betts to hit a home run (+520 via FanDuel)
• Isaac Paredes to hit a home run (+440 via FanDuel)

Parlay odds: +49986 via FanDuel ($10 to win $4,998.61)

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💡 Expert MLB predictions today

• MLB home run predictions today
• Tigers vs. Giants prediction
• Red Sox vs. Blue Jays prediction
• Mets vs. Cubs prediction
• Dodgers vs. Diamondbacks prediction

❓ Best home run predictions FAQs

What are the best home run props for tonight?

My best home run predictions today feature Mookie Betts (+525), Bryce Harper (+340), Aaron Judge (+240), and Isaac Paredes (+440). 

What is a home run bet?

A home run bet is a wager on a hitter to hit a HR at any point during a game. Some sportsbooks allow you to bet on a hitter to not hit a home run, but the most common bet is on them to do so.

Can you parlay home run bets?

Yes, you can parlay home run bets. We've provided our best home run parlay today.

How do I place a home run bet? 

To place a home run bet, simply go to your favorite sportsbook and go to the game featuring the player of your choice. Then click on batter props and you should see an option to bet a player to hit a home run.

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