South Carolina vs. Alabama Prediction, Picks & Odds: Week 7

Our South Carolina vs. Alabama prediction expects the Gamecocks to be in for a world of hurt when they travel to Tuscaloosa after the Tide's shocking Week 6 defeat.

Brenden Schaeffer

Last updated: October 11, 2024 4:18 PM EDT • 4 min read

Alabama Crimson Tide quarterback Jalen Milroe runs the ball and scores against Vanderbilt as we offer our South Carolina vs. Alabama prediction. — Alabama Crimson Tide quarterback Jalen Milroe runs the ball and scores against Vanderbilt. Photo by Steve Roberts via Imagn Images

Saturday’s matchup between the South Carolina Gamecocks and the Alabama Crimson Tide will seek to answer the question: How will Alabama respond after losing to Vanderbilt and seeing the goalposts end up in the Cumberland River?

Alabama's college football championship odds took a hit after the shocking defeat. Now, we'll see how much character this edition of the Crimson Tide has.

Our South Carolina vs. Alabama prediction, part of our Week 7 college football predictions, looks for the Tide to sharpen things up after seeing their margin of error evaporate.

Best South Carolina vs. Alabama picks

College football picks based on the odds from our best college football betting sites. Odds subject to change.

Against the spread pick: Alabama -21.5 (-105 via FanDuel) vs. South Carolina ⭐⭐⭐⭐
My best bet: Jalen Milroe Over 239.5 passing yards (-115 via bet365) ⭐⭐⭐⭐⭐

South Carolina vs. Alabama against the spread prediction: Week 7

Alabama to cover the spread: -21.5 (-105) ⭐⭐⭐⭐

South Carolina vs. Alabama opening odds:

South Carolina: +20.5 (-105)
Alabama: -20.5 (-115)

Although South Carolina’s 31-6 win over Kentucky was arguably the best road effort of any SEC team thus far, the Gamecocks have a timing problem this weekend when they travel to Tuscaloosa.

Alabama's wakeup call has come at the worst possible time for a South Carolina team that hoped to catch the Tide napping.

Tide ready to shore up the defense?

Vanderbilt’s Diego Pavia gave the Alabama coaching staff plenty of teaching points for how to defend a tricky dual-threat quarterback.

Although Bama failed the test last week, it should be prepared for a LaNorris Sellers-led offense that failed to post a touchdown in a 27-3 home loss to Ole Miss. South Carolina's total sits at 13.5 at FanDuel.

On the road against an Alabama defense that still rates 13th in the nation in adjusted defensive efficiency, I’m fading South Carolina’s offense that ranks 102nd in adjusted efficiency.

Conversely, Bama’s 35 points against Vandy was the only time it hasn’t cleared 40 this season.

This 21.5-point spread doesn’t feel adequate to contain the Tide in a key bounce-back spot at home, where it has gone 2-1 ATS. FanDuel’s -105 odds on the Bama spread offer better value than the -110 and -108 offerings found at our other best sports betting sites.

Best odds: -105 via FanDuel | Implied probability: 51.22%

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South Carolina vs. Alabama best bet

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Jalen Milroe Over 239.5 passing yards (-115) ⭐⭐⭐⭐⭐

While South Carolina’s pass defense looks sturdy on a season-long basis, allowing only 185.6 passing yards per game, its first real test against a quality opponent exposed the unit last week.

No more stat-padding for the SC defense

Ole Miss QB Jaxson Dart needed only 14 completions to rack up 285 passing yards against the Gamecocks, as every completed pass felt like an explosive play.

Against a receiving corps that includes the eye-popping talents of Ryan Williams, that’s a concerning development for the South Carolina secondary.

South Carolina’s solid 32nd-ranked run defense could mean keeping Jalen Milroe’s arm involved in the game plan for the duration. After clearing 300+ passing yards in consecutive games, the YAC potential of his talented receivers should allow for another productive day for Milroe.

We’re attacking this prop at bet365, getting -115 odds on Over 239.5 yards rather than the 240.5-yard line found at BetMGM and Caesars.

Best odds: -115 via bet365 | Implied probability: 53.49%

South Carolina vs. Alabama odds

See all of this week's college football odds and NCAAF scores.

South Carolina vs. Alabama game info

When: Saturday, Oct. 12
Kickoff: Noon ET
Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
How to watch: ABC
Weather: 75 degrees, 0% chance of precipitation, wind 3 mph SW
Favorite: Alabama -21.5 (-105 via FanDuel)

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Written By:
Brenden Schaeffer

Brenden has covered the St. Louis Cardinals as a credentialed baseball writer for KMOV-TV since 2016. His sports writing has appeared in outlets including the Austin American-Statesman and Columbia Daily Tribune. Since 2021, Brenden has co-hosted 'The Big Show' during the afternoon drive for KTGR, the ESPN radio affiliate in Columbia, MO. He has appeared on radio stations around the country, including KMOX, and hosts a daily St. Louis Cardinals podcast. In the sports betting content space, Brenden has covered the NFL, college football, NBA, and college basketball for outlets including SBR since 2019. For his football handicapping, Brenden looks to target NFL player prop markets as well as sharp underdog lines in college football. Brenden looks to reference FanDuel for his sports betting articles because of its consistently competitive odds on parlays. FanDuel's boost offerings are also customer-friendly, and its odds on the NFL Same Game Parlay articles he's written for SBR have historically been consistently competitive compared to other books.