Ohio State vs. Oregon Prediction, Picks & Odds: Week 7

In the biggest matchup of a loaded Week 7 slate, Ohio State heads to Autzen Stadium to take on Oregon in a battle of top-three teams.

Rob Paul

Last updated: October 11, 2024 2:09 PM EDT • 5 min read

Ohio State wide receiver Jeremiah Smith gets past Iowa defensive back Koen Entringer. We're backing Smith in our Ohio State vs. Oregon prediction. — Ohio State wide receiver Jeremiah Smith gets past Iowa defensive back Koen Entringer. Photo by Kyle Robertson/Columbus Dispatch/USA TODAY NETWORK via Imagn Images.

Love it or hate it, conference realignment is giving the college football world this banger of an early October Big Ten battle between Ohio State and Oregon on Saturday at 7:30 p.m. ET (NBC, Peacock) from Autzen Stadium in Eugene, Ore.

With both overwhelming favorites by the College Football Playoff odds, we expect the Buckeyes to cover the 3.5-point spread in our Ohio State vs. Oregon prediction
Ohio State has the shortest college football championship odds (+280) and a win over Oregon could move the Buckeyes to prohibitive favorites
One of just eight players with Heisman Trophy odds shorter than 25/1, Dillon Gabriel could move into the top four favorites with a Ducks win

The only game in our Week 7 college football predictions featuring two top-10 teams, Ohio State vs. Oregon could be one of the best games of the year.

Best Ohio State vs. Oregon picks

College football picks based on the odds from our best college football betting sites. Odds subject to change.

Against the spread pick: Ohio State -3.5 (+100 via BetMGM) vs. Oregon ⭐⭐⭐⭐
My best bet: Jeremiah Smith anytime touchdown scorer (-115 via Caesars) ⭐⭐⭐⭐

Ohio State vs. Oregon against the spread prediction: Week 7

Ohio State to cover the spread: -3.5 (+100) ⭐⭐⭐⭐

Ohio State vs. Oregon opening odds:

Ohio State: -4 (-110)
Oregon: +4 (-110)

Ranked No. 2 and No. 3 respectively in the AP Top 25, neither Ohio State or Oregon has actually played a ranked Power 4 team this season.

However, while the Buckeyes have run through each of their opponents with relative ease, the Ducks have left a lot to be desired - especially on defense. Oregon ranks just 21st in SP+ on defense and is 1-4 ATS as a result.

That includes this defense giving up 34 to Boise State with Ashton Jeanty exploding for 192 yards on the ground. Obviously, Quinshon Judkins and TreVeyon Henderson aren't quite at Jeanty's level, but they're still two of the best backs in the country.

They have Ohio State ranked first in EPA per rush on offense and they should be capable of getting after an Oregon defense that's allowing more rushing yards (101.4) than seven other teams in the Big Ten.

Throwing ducks

Despite Ohio State's offense having some of the best playmakers in the country, the defense should be the reason the Buckeyes cover this spread. Jim Knowles' unit is first in the country in SP+ and top two in both EPA per rush and dropback.

That spells trouble for Gabriel, who has the Ducks ranked outside of the top 25 in EPA per dropback. He's been efficient but has the seventh-lowest ADOT in the country (6.5) and just seven big-time throws, per PFF.

That's not going to cut it against a defense allowing the fourth-fewest passing yards per game (129.8) and third-fewest rushing yards (72.6). The Buckeyes have covered in two straight, and if they do again, a $10 bet pays a $10 profit.

Best odds: +100 via BetMGM | Implied probability: 50%

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Ohio State vs. Oregon best bet

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Jeremiah Smith anytime touchdown scorer (-115) ⭐⭐⭐⭐

It ain't rabbit hunting season; it's duck hunting season. And Jeremiah Smith is a more explosive weapon than anything Elmer Fudd was ever armed with back in the day.

Smith is having one of the best freshman seasons of all time and is a serious Heisman sleeper through five games. He leads the Buckeyes in touchdowns (seven) and has scored in every game this season.

He ranks top 10 in the country in yards per route run (3.68) and Oregon has yet to see a receiver that's even top 90 in the country in receiving yards. At this price, another Smith score would turn a $10 bet into an $8.70 profit.

Best odds: -115 via Caesars | Implied probability: 53.49%

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Ohio State vs. Oregon odds

See all of this week's college football odds and NCAAF scores.

Ohio State vs. Oregon game info

When: Saturday, Oct. 12
Kickoff: 7:30 p.m. ET
Where: Autzen Stadium (Eugene, Ore.)
How to watch: NBC, Peacock
Weather: 64 degrees, 10% chance of precipitation, wind 4 mph NW
Favorite: Ohio State -3.5 (+100 via BetMGM)

College football betting odds pages

College football championship odds	College football win totals	Big Ten championship odds	Mountain West championship odds
Heisman Trophy Odds	FCS Championship odds	Big 12 championship odds	MAC championship odds
College Football Playoff Odds	SEC championship odds	ACC championship odds	College bowl game odds

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Written By:
Rob Paul

Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining SportsbookReview.com, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.