College Football Opening Odds for Week 2: Top 25 Matchup Betting Lines

Here are the opening odds for college football's Week 2 slate with moneylines, spreads, and totals for notable games.

Gabe Henderson

Last Updated: September 2, 2025 2:13 PM EDT • 6 minute read

College Football Opening Odds for Week 2: Betting Lines & Spreads for Ranked Games — Pictured: Michigan quarterback Bryce Underwood passes. Photo by Junfu Han / USA TODAY NETWORK via Imagn Images.

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📊 College football odds for Week 2

The opening college football odds for Week 2 are via FanDuel.

Game	Spread	Moneyline	Over/Under
San Jose State vs. No. 7 Texas	Texas -36.5	N/A	51.5
Florida International vs. No. 2 Penn State	Penn State -41.5	N/A	54.5
No. 11 Illinois vs. Duke	Illinois -2.5	Illinois -146	50.5
Baylor vs. No. 17 SMU	SMU -2.5	SMU -134	65.5
Kennesaw State vs. No. 23 Indiana	Indiana -35.5	N/A	50.5
Iowa vs. No. 16 Iowa State	Iowa State -2.5	Iowa State -146	41.5
Kent State vs. No. 24 Texas Tech	Texas Tech -48.5	N/A	58.5
Utah State vs. No. 19 Texas A&M	Texas A&M -29.5	Texas A&M -10000	54.5
Troy vs. No. 8 Clemson	Clemson -33.5	N/A	51.5
Oklahoma State vs. No. 6 Oregon	Oregon -28.5	Oregon -7000	56.5
No. 20 Ole Miss vs. Kentucky	Ole Miss -10.5	Ole Miss -365	51.5
South Florida vs. No. 13 Florida	Florida -17.5	Florida -850	53.5
Louisiana Tech vs. No. 3 LSU	LSU -37.5	N/A	51.5
No. 12 Arizona State vs. Mississippi State	Arizona State -6.5	Arizona State -225	58.5
No. 15 Michigan vs. No. 18 Oklahoma	Oklahoma -5.5	Oklahoma -196	46.5
UL Monroe vs. No. 21 Alabama	Alabama -37.5	N/A	50.5

Multiple ranked teams do not feature because their games versus FCS opponents do not have betting lines as of the latest update. These games include Grambling vs. No. 1 Ohio State, Austin Peay vs. No. 4 Georgia, East Texas A&M vs. No. 14 Florida State, East Tennessee State vs. No. 22 Tennessee, Bethune-Cookman vs. No. 5 Miami, South Carolina State vs. No. 10 South Carolina, and Cal Poly vs. No. 25 Utah.

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The Week 2 schedule and odds are less exciting than those in Week 1, with not as much ranked action across the board. Below, we break down the latest betting odds, as well as kickoff and television info for each contest.

All eyes will be on Norman, Okla., with Michigan vs. Oklahoma providing viewers with the only top 25 matchup of the weekend. Iowa vs. Iowa State also headlines a slate chock-full of in-state showdowns.

🏈 San Jose State vs. Texas odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: DKR-Texas Memorial Stadium (Austin, Texas)
How to watch: Local TV

Texas opens up as a five-touchdown favorite against San Jose State, despite the Longhorns' Week 1 struggles in Columbus. This is a great get-right game for Arch Manning as he continues to grow into the full-time starter role. This is the start of a three-week stretch where Steve Sarkisian's squad will be heavy betting favorites before Florida comes to town on Oct. 4.

🏈 Florida International vs. Penn State odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Beaver Stadium (University Park, Pa.)
How to watch: Big Ten Network

🏈 Illinois vs. Duke odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Wallace Wade Stadium (Durham, N.C.)
How to watch: Local TV

🏈 Baylor vs. SMU odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Gerald J. Ford Stadium (Dallas)
How to watch: The CW Network

🏈 Kennesaw State vs. Indiana odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Memorial Stadium (Bloomington, Ind.)
How to watch: FS1

🏈 Iowa vs. Iowa State odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Jack Trice Stadium (Ames, Iowa)
How to watch: FOX

Iowa State opens as a 2.5-point betting favorite over its in-state rival following a massive Week 0 victory over Kansas State in Ireland. While the Cyclones have beaten the Hawkeyes straight up in two of the last three seasons, they haven't won this game in Ames since 2011. Oddsmakers at the best sports betting sites have set the total at O/U 41.5.

🏈 Kent State vs. Texas Tech odds

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Jones AT&T Stadium (Lubbock, Texas)
How to watch: HBO Max, TNT

🏈 East Texas A&M vs. Florida State game info

When: Saturday, Sept. 6
Kickoff: Noon ET
Where: Doak Campbell Stadium (Tallahassee, Fla.)
How to watch: ACC Network

🏈 Utah State vs. Texas A&M odds

When: Saturday, Sept. 6
Kickoff: 12:45 p.m. ET
Where: Kyle Field (College Station, Texas)
How to watch: SEC Network

🏈 Grambling vs. Ohio State game info

When: Saturday, Sept. 6
Kickoff: 3:30 p.m. ET
Where: Ohio Stadium (Columbus, Ohio)
How to watch: Big Ten Network

🏈 Troy vs. Clemson odds

When: Saturday, Sept. 6
Kickoff: 3:30 p.m. ET
Where: Memorial Stadium (Clemson, S.C.)
How to watch: ACC Network

🏈 Austin Peay vs. Georgia game info

When: Saturday, Sept. 6
Kickoff: 3:30 p.m. ET
Where: Sanford Stadium (Athens, Ga.)
How to watch: ESPN+, SEC Network+

🏈 Oklahoma State vs. Oregon odds

When: Saturday, Sept. 6
Kickoff: 3:30 p.m. ET
Where: Autzen Stadium (Eugene, Ore.)
How to watch: CBS, Paramount+

Dante Moore passed his first test with flying colors as Oregon smacked around Montana State in a 59-13 victory. But how will Mike Gundy's new-look Oklahoma State team fare against the young quarterback's Ducks? Oddsmakers have chimed in, listing the Autzen Stadium occupants as four-touchdown favorites over their Big 12 adversaries.

🏈 Ole Miss vs. Kentucky odds

When: Saturday, Sept. 6
Kickoff: 3:30 p.m. ET
Where: Kroger Field (Lexington, Ky.)
How to watch: ABC

🏈 East Tennessee State vs. Tennessee game info

When: Saturday, Sept. 6
Kickoff: 3:30 p.m. ET
Where: Neyland Stadium (Knoxville, Tenn.)
How to watch: ESPN+, SEC Network+

🏈 South Florida vs. Florida odds

When: Saturday, Sept. 6
Kickoff: 4:15 p.m. ET
Where: Ben Hill Griffin Stadium (Gainesville, Fla.)
How to watch: SEC Network

After South Florida's dominant showing against Boise State, this intrastate scuffle looks a lot more tasty. Many fans are putting Florida on upset watch, but the best sports betting apps aren't being as hyperbolic. The Gators are 18.5-point favorites over the Bulls in the Swamp.

🏈 Cal Poly vs. Utah game info

When: Saturday, Sept. 6
Kickoff: 6 p.m. ET
Where: Rice-Eccles Stadium (Salt Lake City)
How to watch: ESPN+

🏈 Bethune-Cookman vs. Miami game info

When: Saturday, Sept. 6
Kickoff: 7 p.m. ET
Where: Hard Rock Stadium (Miami Gardens, Fla.)
How to watch: ACC Network+, ESPN+

🏈 South Carolina State vs. South Carolina game info

When: Saturday, Sept. 6
Kickoff: 7 p.m. ET
Where: Williams-Brice Stadium (Columbia, S.C.)
How to watch: ESPN+, SEC Network+

🏈 Louisiana Tech vs. LSU odds

When: Saturday, Sept. 6
Kickoff: 7:30 p.m. ET
Where: Tiger Stadium (Baton Rouge, La.)
How to watch: ESPN+, SEC Network+

🏈 Arizona State vs. Mississippi State odds

When: Saturday, Sept. 6
Kickoff: 7:30 p.m. ET
Where: Davis Wade Stadium (Starkville, Miss.)
How to watch: ESPN2

🏈 Michigan vs. Oklahoma odds

When: Saturday, Sept. 6
Kickoff: 7:30 p.m. ET
Where: Memorial Stadium (Norman, Okla.)
How to watch: ABC

The only ranked matchup of the week sees Michigan hit the road, with true freshman signal caller Bryce Underwood facing his first big test on the collegiate scene. The sportsbooks must not've liked what they saw from the Wolverines in Week 1. Oklahoma opened at -2.5, but as of Sunday night, the Sooners are 5.5-point betting favorites at home.

🏈 UL Monroe vs. Alabama odds

When: Saturday, Sept. 6
Kickoff: 7:45 p.m. ET
Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
How to watch: SEC Network

🔢 College football Week 2 odds and lines

There's an advantage to betting the early college football odds when attempting to beat the closing line. The closer you wait until kickoff to make your college football picks, the more difficult it becomes to identify edges and secure the best price on most sides or totals.

That's why it's important to start monitoring the college football opening odds each week as soon as possible. A proactive approach is the first step to long-term success.

❓College football odds FAQs

How do college football spread odds work?

When betting on college football, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do college football moneyline odds work?

When betting on college football, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

Where can I find the best college football betting odds?

Shop around our best college football betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years bulding his college football and NFL experience. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.

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