College Football Predictions & Odds 2025 Week 0: Best Bets for Marquee Games

The wait for the 2025 college football season is just about over, as there are five games involving FBS programs on tap for Saturday. We highlight them all with our college football Week 0 predictions and odds.

That includes an AP Top 25 edition of Farmaggedon in Dublin, Ireland, to the other side of the world (about 7,000 miles away), where Andrew Luck's Stanford takes on Hawaii in Honolulu, with pit stops in Las Vegas, Kansas, and Kentucky along the way, this Saturday kicks off the college football national championship odds race.

While there are no Heisman Trophy odds contenders poised to take the field this weekend, it's the appetizer for a loaded Week 1 featuring a plethora of teams in the College Football Playoff odds hunt.

🏈 College football predictions for Week 0

🔎 Our college football player prop odds tool can help you find the best college football odds to make your college football picks across legal sportsbooks in your region.

• Iowa State vs. Kansas State early odds
• Iowa State vs. Kansas State prediction
• Iowa State vs. Kansas State player props
• Iowa State vs. Kansas State parlay picks
• Iowa State vs. Kansas State touchdown scorer predictions
• Idaho State vs. UNLV early odds
• Idaho State vs. UNLV prediction
• Idaho State vs. UNLV player props (coming soon)
• Idaho State vs. UNLV parlay picks
• Fresno State vs. Kansas early odds
• Fresno State vs. Kansas prediction
• Fresno State vs. Kansas player props
• Fresno State vs. Kansas parlay picks
• Sam Houston vs. Western Kentucky early odds
• Sam Houston vs. Western Kentucky prediction
• Sam Houston vs. Western Kentucky player props
• Sam Houston vs. Western Kentucky parlay picks
• Stanford vs. Hawaii early odds
• Stanford vs. Hawaii prediction
• Stanford vs. Hawaii player props
• Stanford vs. Hawaii parlay picks (coming soon)
• Stanford vs. Hawaii touchdown scorer predictions (coming soon)

💰 College football odds & expert picks: Week 0

Here are the latest odds for every Week 0 game via the best college football betting sites, which update live in real time. 

📊 Idaho State vs. UNLV odds

• Date: Saturday, Aug. 23
• Kickoff: 4 p.m. ET
• Location: Allegiant Stadium (Las Vegas)
• How to watch: YouTubeTV, Fubo

🔮 Idaho State vs. UNLV prediction: Idaho State +27.5

✅ Best pick: Idaho State +27.5 (-110 via BetMGM)

Here's a sneak peek at why Mike Spector is backing Idaho State to cover the spread: 

"Former Mississippi State and Florida head coach Dan Mullen takes over a UNLV program that was resurrected by Barry Odom. The Rebels averaged 3.3 wins per season in the 28 years before Odom arrived, then promptly won 20 games in those two years. 

Because of that success, UNLV is overvalued to start the season, especially since it ranks 132nd in returning production (34% on offense, 29% on defense) and is breaking in at least 20 new starters."

👉 Check out his full analysis in our Idaho State vs. UNLV prediction.

📊 Fresno State vs. Kansas odds

• Date: Saturday, Aug. 23
• Kickoff: 6:30 p.m. ET
• Location: David Booth Kansas Memorial Stadium (Lawrence, Kans.)
• How to watch: FOX

🔮 Fresno State vs. Kansas prediction: Kansas -12.5

✅ Best pick: Kansas -12.5 (-120 via BetMGM)

Here's a sneak peek at why Isaiah Sirois is backing Kansas to cover the spread: 

"Kansas by 12.5 was a much better bet at -110 (52.4%), but playing the -120 (54.6%) juice for it isn’t a terrible proposition. Consistency matters, especially in the early part of the year, and that’s just what the Jayhawks have. 

Kansas returns head coach Lance Leipold, and while last year’s offensive coordinator is no longer with the program, his replacement, Jim Zebrowski, was the previous quarterbacks coach and co-offensive coordinator. They’ll work with longtime Kansas quarterback Jalon Daniels."

👉 Check out his full analysis in his Fresno State vs. Kansas prediction.

📊 Sam Houston vs. Western Kentucky odds

• Date: Saturday, Aug. 23
• Kickoff: 7 p.m. ET
• Location: Houchens Industries-L.T. Smith Stadium (Bowling Green, Ky.)
• How to watch: CBSSN

🔮 Sam Houston vs. Western Kentucky prediction: Sam Houston +10.5

✅ Best pick: Sam Houston +10.5 (-108 via FanDuel)

Here's a sneak peek at why Phil Wood is backing Sam Houston to cover the spread: 

"The Hilltoppers have 16 new starters this season, which is one of the main reasons you can’t give too much weight to the Hilltoppers' 31-14 win at Sam Houston last season. The other reason is that Bearkats’ starting quarterback, Hunter Watson, got hurt in that game. When he left, his team trailed just 17-14.

With Watson back, I’m surprised the spread has consistently moved in favor of Western Kentucky."

👉 Check out his full analysis in our Sam Houston vs. Western Kentucky prediction.

Bet $5, Win $300 in Bonus Bets

New customers only. Min. first deposit and wager of $5+. Bonus bets are awarded within 72 hours of winning your first wager. T&Cs apply.

Claim $300

📊 Stanford vs. Hawaii odds

• Date: Saturday, Aug. 23
• Kickoff: 7:30 p.m. ET
• Location: Clarence T.C. Chung Athletics Complex (Honolulu)
• How to watch: CBS

🔮 Stanford vs. Hawaii prediction: Under 50.5

✅ Best pick: Under 50.5 (-110 via bet365)

Here's a sneak peek at why Brenden Schaeffer is backing Sam Houston to cover the spread: 

"The Hilltoppers have 16 new starters this season, which is one of the main reasons you can’t give too much weight to the Hilltoppers' 31-14 win at Sam Houston last season. The other reason is that Bearkats’ starting quarterback, Hunter Watson, got hurt in that game. When he left, his team trailed just 17-14.

With Watson back, I’m surprised the spread has consistently moved in favor of Western Kentucky."

👉 Check out his full analysis in our Stanford vs. Hawaii prediction.

💡 College football Week 0 expert picks

• College football Week 0 picks against the spread
• College football Week 0 upset picks and predictions
• College football Week 0 betting trends
• College football player props Week 0
• College football Week 0 parlay picks
• College football Week 0 touchdown scorer predictions

🏆 College football odds pages

(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.

Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.