Early LSU vs. Clemson Prediction: Week 1 Odds & Picks

Clemson and LSU cap off a fantastic first full Saturday of college football action in Week 1, but which set of Tigers have the upper hand?

Gabe Henderson

Last Updated: August 26, 2025 9:55 AM EDT • 4 minute read

LSU vs. Clemson Prediction: Odds & Picks for Week 1 — Pictured: LSU Tigers quarterback Garrett Nussmeier (13) signals a first down as I highlight my LSU vs. Clemson early prediction and odds. Photo by Stephen Lew via Imagn Images.

A full Saturday slate in Week 1 is capped off by a top 10 clash, and my LSU vs. Clemson early odds and picks analyze the contest between two of the top college football championship odds contenders.

Dabo Swinney's team remains a 3.5-point betting favorite, with a total set at O/U 57.5 points. Kickoff is slated for 7:30 p.m. ET (ESPN) on Saturday night from Memorial Stadium in Clemson, S.C.

Which Tigers will leave the ACC's "Death Valley" with a 1-0 record? I dive into my LSU vs. Clemson early pick down below.

Best LSU vs. Clemson early prediction: Week 1 💰

🔎 College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Prediction: LSU +3.5 ⭐⭐⭐

Best odds: -105 via bet365 | Implied probability: 51.22%

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Both teams come into the season with College Football Playoff odds aspirations behind their superstar quarterbacks. The Heisman Trophy odds favorites are each surrounded by an abundance of talent, with Clemson ranked 10th and LSU ranked 11th in SP+.

The difference between the two sides is the continuity. Clemson returns several key pieces, including its top wideouts, to complement Cade Klubnik. LSU is tasked with overhauling its offensive line and receiving corps around Garrett Nussmeier, and is looking for Blake Baker to take a leap in his second year as DC.

My LSU vs. Clemson early predictions back the visitors to keep it closer than the spread suggests because of the plethora of playmakers at Nussmeier's disposal. Dabo Swinney's team has a 47.4% cover rate as a home favorite over the last three seasons, whereas Brian Kelly's boys are 5-5 ATS as underdogs.

LSU vs. Clemson early odds 📈

See the college football odds from our best college football betting sites.

LSU vs. Clemson opening odds

Moneyline: LSU +125 | Clemson -150
Spread: LSU +3 (-110) | Clemson -3 (-110)
Over/Under: Over 56.5 (-110) | Under 56.5 (-110)

LSU vs. Clemson odds analysis

Lopsided action on Clemson has seen the favorite's odds shorten as kickoff approaches. The host Tigers moved from -150 to -175 after earning 74% of moneyline action at BetMGM.

A hook got added to the spread, as well, but with LSU receiving just under 50% of bets with the points, I can't imagine this gap growing any larger barring a sizable bet or significant injury news. Your best chance to bet on the Bayou Bengals might be right now while you're still getting shorter than standard juice.

Don't miss our guide for how to bet on college football or this week's best sportsbook promos.

LSU vs. Clemson betting insights 📊

Here are some betting insights from our college football odds on Tuesday morning.

Despite a slight majority of bets on LSU to cover the spread (51%), the line looks likelier to move to Clemson -4, as the -3.5 line is trading at -115 currently
The hosts' moneyline odds continue to shorten. Clemson opened at -150, began Monday at -175, and that line is now -185
57% of total bettors expect the Tigers to combine for Over 57.5 points, which has remained the O/U, despite early lopsided action

LSU vs. Clemson injuries to watch 🚑

How to watch LSU vs. Clemson 📺

When: Saturday, Aug. 30
Kickoff: 7:30 p.m. ET
Where: Clemson Memorial Stadium (Clemson, S.C.)
How to watch: ESPN
Weather: 61 degrees, 5% chance of precipitation, wind 6 mph E
Favorite: Clemson (-175 via BetMGM)

Expert early Week 1 college football predictions, odds & picks 💡

College football betting odds pages 📃

CFP National Championship odds	Heisman Trophy odds	College Football Playoff odds	College Football Playoff bracket
ACC odds	Big Ten odds	Big 12 odds	SEC odds

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Written by:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.