Iowa State vs. Kansas State Prediction, Betting Odds & Expert Picks: College Football Week 0

Last Updated: August 22, 2025 7:00 AM EDT • 4 minute read X Social Google News Link

The college football season and Week 0 gets started with a massive AP top 25 showdown among Big 12 Conference elites, as the Iowa State Cyclones and Kansas State Wildcats face off at Aviva Stadium in Dublin. We break the matchup down with my Iowa State vs. Kansas State prediction, which has kickoff set for noon ET (ESPN).
Kansas State is a 3-point betting favorite at our top sports betting sites, and our college football Week 0 predictions fade Iowa State as underdogs, while expecting its experienced quarterback to struggle getting acclimated to his new perimeter weapons.
📊 Iowa State vs. Kansas State odds: Week 0
Live updated odds from our best college football betting sites. Follow the latest college football scores for line history and matchup info.
🏈 Iowa State vs. Kansas State expert picks
College football picks made Thursday; odds subject to change.
✅ Moneyline pick: Kansas State (-155 via DraftKings) ⭐⭐⭐⭐
✅ Against the spread pick: Kansas State -3 (-110 via BetMGM) ⭐⭐⭐⭐
✅ Over/Under pick: Under 50.5 (-108 via DraftKings) ⭐⭐⭐

🔮 Iowa State vs. Kansas State prediction & best bet
🔎 Our college football player prop odds tool can help you find the best college football odds across legal sportsbooks in your area!
🐾 Kansas State -3 (-110) ⭐⭐⭐⭐
Fading Matt Campbell’s Iowa State team in what is projected to be a one-score game may seem like blasphemy, considering the Cyclones went 5-1 in one-possession games last season and are 7-2 in their last nine overall. But that is also the sort of thing that regresses to the mean, just like how Iowa State was 1-11 in one-score games from 2021 to early 2023.
Early in the season I tend to give the nod to teams with more returning production, and here that edge goes to the Wildcats.
Kansas State lost its last two regular-season finales to Iowa State, but I expect a different result with this being the season opener, especially since the Wildcats won seven of their first eight games last year.
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
💰 Best Iowa State vs. Kansas State player prop bet

⬇️ Rocco Becht Under 229.5 passing yards ⭐⭐⭐⭐⭐
Rocco Becht enters his third year as Cyclones starting quarterback, but I am backing the Under on his passing yards primarily because of the weapons Iowa State’s offense lost.
The Cyclones were among the top 35 of all FBS teams in EPA per pass, but their top two wide receivers, Jayden Higgins and Jaylin Noel, are gone after combining for 167 catches and 2,377 yards. That leaves Carson Brown as the team’s leading returning wide receiver, and he had just 11 catches last year.
I look for Iowa State to lean on its running game while getting its perimeter players more up to speed.
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
🚑 Iowa State vs. Kansas State injuries
❓Iowa State vs. Kansas State FAQs
Who is the favorite to win Iowa State vs. Kansas State?
Kansas State is favored by 3 points at our top sports betting sites against Iowa State.
How do college football spread odds work?
When betting on college football, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do college football moneyline odds work?
When betting on college football, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the best college football betting odds?
Shop around our best college football betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
🏆 College football betting odds
CFP National Championship Odds | Heisman Trophy odds | College Football Playoff Odds | College Football Playoff Bracket |
ACC Odds | Big Ten Odds | Big 12 Odds | SEC Odds |
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission

Mike Spector X social