Iowa State vs. Kansas State Early Odds, Picks & Prediction for Week 0: Aug. 23

The first meeting of the season between ranked teams takes place in the Aer Lingus College Football Classic in Dublin.

Mike Spector

Last Updated: August 21, 2025 6:59 AM EDT • 4 minute read

Iowa State vs. Kansas State Early Odds, Picks & Prediction for Week 0: Aug. 23 — Pictured: Kansas State Wildcats running back Dylan Edwards runs for a touchdown as we make our best Iowa State vs. Kansas State early picks. Photo by Mark J. Rebilas via Imagn Images.

The 2025 college football season gets underway on Saturday with a Big 12 clash between No. 22 Iowa State and No. 17 Kansas State in Dublin. My Iowa State vs. Kansas State early odds and picks look at key betting numbers for the AP top 25 battle, and aim to predict line movement throughout the week as part of our College Football Week 0 predictions.

Kickoff for the Aer Lingus College Football Classic from Aviva Stadium is set for noon ET (ESPN).

📈Iowa State vs. Kansas State early odds

See the college football odds from our best college football betting sites for every college football bowl game.

Iowa State vs. Kansas State opening odds

Moneyline: Iowa State +140 / Kansas State -165
Spread: Iowa State +3.5 (-110) / Kansas State -3.5 (-110)
Over/Under: Over 49.5 (-110) / Under 49.5 (-110)

Iowa State vs. Kansas State odds analysis

FanDuel is the only one of our best sports betting apps that is currently at its same opening number of Kansas State -3.5, with the +3.5 juiced to -120. That suggests there is a chance the point spread lowers and aligns with the other -3’s (and kicks off at that number), since all other best sportsbooks apps have come down from -3.5.

Caesars has seen the most volatility in its point spread, spending time anywhere from -2.5 to -4. Not surprisingly, the -2.5’s nor the -4’s lasted long.

The total has been the much more stable number, remaining firm at O/U 49.5 at most shops. Caesars was the only one who saw any movement on the total, aligning with the rest of the shops with the best sportsbook promos at 49.5 after opening at 49.

💰 Best Iowa State vs. Kansas State early prediction: Week 0

🔎 College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

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✅ Prediction: Kansas State -3 ⭐⭐⭐

📊 Best odds: -105 via Caesars | Implied probability: 51.22%

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I am heading to Caesars to back the Wildcats to cover the field goal spread with my Iowa State vs. Kansas State early predictions, as it’s the only top sports betting site charging less than the standard -110 juice. With the chances much more likely that the line moves up to -3.5 than down to -2.5, -3 is likely the best number we will get going forward.

Iowa State, being a three-point underdog after its only 11-win season in school history, speaks to what it lost on offense. The Cyclones will not be as dynamic to begin the season after losing their top two wide receivers, who combined for 167 catches and nearly 2,400 yards, and their leading returning receiver had 11 receptions a year ago.

Kansas State has +380 odds at DraftKings to make the College Football Playoff compared to Iowa State at +900, and that likely factors in who will win this season opener. I expect regression from a Cyclones team that finished 5-1 in one-score games last year, with the more experienced Wildcats (14th in returning production) covering. It's a pick that our Rob Paul likes, as he outlines in his college football Week 0 ATS picks.

🚑 Iowa State vs. Kansas State injuries to watch

📈 Iowa State vs. Kansas State betting insights

Here are some betting insights from our best sports betting sites on Thursday morning

The spread is largely trading at 3 points since opening at 3.5 points, although rogue 3.5s still exist
The moneyline can be found as short at -150 after opening at -165
The total had held at 49.5 points through the first couple of days of the week, but is now regularly trading at 50.5

📺 How to watch Iowa State vs. Kansas State

When: Saturday, Aug. 23
Kickoff: Noon ET
Where: Aviva Stadium (Dublin)
How to watch: ESPN
Weather: 69 degrees, 19% chance of precipitation, wind 9 mph ESE
Favorite: Kansas State -3 (-110 via BetMGM)

💡 Expert Week 0 college football early picks

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📃 College football betting odds pages

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Heisman Trophy Odds	FCS Championship odds	Big 12 championship odds	MAC championship odds
College Football Playoff Odds	SEC championship odds	ACC championship odds	College bowl game odds

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”