United States vs. Uruguay Prediction & Odds: International Betting Preview for Nov. 18

The United States will close out 2025 with another challenging fixture, as my United States vs. Uruguay prediction anticipates a tight contest.

The action at Raymond James Stadium in Tampa, Fla., starts at 7 p.m. ET (TNT/truTV/HBO Max). Mauricio Pochettino’s U.S. squad enters this contest as a +190 betting underdog against a World Cup-bound Uruguay team (+160) that hasn’t lost since June.

✅ United States vs. Uruguay prediction & expert picks

See all of our experts' soccer picks this week.

⚽ United States vs. Uruguay preview & score prediction

Although there’s nothing but pride on the line, expect a physical international friendly in which both teams are inspired to end the year on a positive note.

Fresh off beating Paraguay 2-1, the United States will be eager to topple another World Cup-bound South American opponent when Pochettino faces his mentor Marcelo Bielsa and Uruguay.

Uruguay struggled in attack against Mexico but managed to extend its unbeaten run to six games by securing a 0-0 draw.

Injuries to have major impact on scoring

Bielsa’s side faces another difficult game without injured talisman Fede Valverde. But the Argentine tactician will like his team’s chances against a United States squad that’s also dealing with injuries.

Much like Uruguay’s last game, I’m expecting this to be a defensive, low-scoring battle that will go Under 2.5 total goals. The last two meetings between these teams also produced fewer than three total goals.

Considering that there’s little on the line, and that both teams will want to avoid injuries, I think it’s a safe bet that goals will be in short supply.

A $10 bet on the Under at -167 odds at bet365 will net a profit of $6.

Score prediction: United States 1, Uruguay 1

🆚 United States vs. Uruguay matchup to watch

Gio Reyna vs. Uruguay's defense

Look for Gio Reyna to continue to make a case to be included in Pochettino’s final World Cup squad with another strong performance in consecutive international friendlies.

Despite struggling for regular playing time at Borussia Monchengladbach, Reyna showed no signs of rust in scoring and setting up the winning goal for the United States against Paraguay.

I expect the 23-year-old winger to score in consecutive games after breaking down a Uruguay defense that’s two matches removed from conceding against 55th-ranked Uzbekistan.

A successful $10 bet at bet365 will net a profit of $45.

Best prop bet: Gio Reyna anytime goal (+450 via bet365)

📊 United States vs. Uruguay odds

Moneyline (3-way)

• United States: +195 ($10 to win $19.50)
• Uruguay: +150 ($10 to win $15)
• Tie: +200 ($10 to win $20)

Spread

• United States: +1.5, -750 ($75 to win $10)
• Uruguay: -1.5, +470 ($10 to win $47)

Over/Under total goals

• Over 2.5 goals: +142 ($10 to win $14.20)
• Under 2.5 goals: -188 ($18.80 to win $10)

📈 United States vs. Uruguay betting trends & recent form

🌤️ United States vs. Uruguay weather

It’s going to be a comfortable night in Tampa, with the temperature around 72 degrees at kickoff. There’s no rain in the forecast, so the weather shouldn’t impact how the match unfolds.

📺 How to watch United States vs. Uruguay

• Date: Tuesday, Nov. 18
• Kickoff: 7 p.m. ET
• Location: Raymond James Stadium (Tampa, Fla.)
• TV: TNT/truTV/HBO Max