Premier League Best Bets & Predictions: Expert Picks & Odds for Matchweek 2

We make our Premier League best bets for an exciting Matchweek 2 slate, headlined by Tottenham vs. Man City and Liverpool vs. Newcastle.
Premier League Best Bets: Expert Picks, Predictions & Odds for Matchweek 2
Pictured: Liverpool's Mohamed Salah and Newcastle United's Dan Burn battle for the ball as I make my Premier League best bets for Matchweek 2. Photo by Owen Humphreys / PA Images via Sipa USA.

English soccer fans will be treated to another four-day slate of games this weekend, and my Premier League best bets offer up my favorite picks for all 10 matchups.

Marquee meetings to keep an eye on include Tottenham vs. Manchester City and Liverpool vs. Newcastle. I have five plus-money Premier League expert picks for those matches and many more, with odds courtesy of our best sports betting sites.

⚽️ Premier League best bets for Matchweek 2

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  • Arsenal -1.5 vs. Leeds United (-135 via Caesars) ⭐️⭐️⭐️⭐️
  • Nottingham Forest-Crystal Palace draw (+230 via BetMGM) ⭐️⭐️⭐️
  • Everton moneyline vs. Brighton (+220 via FanDuel) ⭐️⭐️
  • Liverpool moneyline vs. Newcastle (+105 via bet365) ⭐️⭐️⭐️

Don't miss the rest of our Matchweek 2 soccer picks.

💰 Premier League odds & expert picks

Here are the latest odds and our expert picks for every game via the best soccer betting sites, which update live in real time.

📊 Leeds United vs. Arsenal odds

  • Date: Saturday, Aug. 24
  • Kickoff: 12:30 p.m. ET
  • Location: Emirates Stadium (London)
  • How to watch: NBC

🔮 Leeds United vs. Arsenal prediction

✅ Best pick: Arsenal -1.5 (-135 via Caesars)

Here's a sneak peek at why I'm predicting Arsenal to cover the spread:

"Arsenal has had tremendous success against newly promoted sides across the last three seasons. Arteta's men have picked up results at an elite rate versus relegation-scrapping squads, but perhaps even more impressively, they've covered as 1.5-goal favorites at a 66% clip (12 of 18 games) against them."

👉 Check out my full analysis in my Leeds United vs. Arsenal prediction

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📊 Nottingham Forest vs. Crystal Palace odds

  • Date: Sunday, Aug. 24
  • Kickoff: 9 a.m. ET
  • Location: Selhurst Park (London)
  • How to watch: Peacock

🔮 Nottingham Forest vs. Crystal Palace prediction

✅ Best pick: Draw (+230 via BetMGM)

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Here's why I am predicting a draw:

This match just screams draw, doesn't it? Crystal Palace and Nottingham Forest are two of the most tactically safe clubs in the Premier League, treating every match like a chess match, waiting for the other to make one misstep to capitalize on it. They combined to draw 22 of 76 matches (28.95%) last season, including their last meeting at Selhurst Park in May.

📊 Brighton vs. Everton odds

  • Date: Sunday, Aug. 24
  • Kickoff: 9 a.m. ET
  • Location: Hill Dickinson Stadium (Liverpool, England)
  • How to watch: USA Network

🔮 Brighton vs. Everton prediction

✅ Best pick: Everton moneyline (+220 via FanDuel)

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Here's why I am predicting Everton to win:

Everton's opening matchday defeat to Leeds United was hugely disappointing, as David Moyes' men came into the campaign with a glimmer of hope for the first time since Carlo Ancelotti was in charge. However, as the Toffees prepare to christen Hill Dickinson Stadium, I'm confident in their ability to beat Brighton for a second time in the Moyes era.

📊 Manchester United vs. Fulham odds

  • Date: Saturday, Aug. 24
  • Kickoff: 11:30 a.m. ET
  • Location: Craven Cottage (London, England)
  • How to watch: USA Network

🔮 Premier League expert picks

Manchester United vs. Fulham prediction

📊 Liverpool vs. Newcastle odds

  • Date: Monday, Aug. 25
  • Kickoff: 3 p.m. ET
  • Location: St. James' Park (Newcastle upon Tyne, England)
  • How to watch: USA Network

🔮 Liverpool vs. Newcastle prediction

✅ Best pick: Liverpool moneyline (+105 via bet365)

Here's why I am predicting Liverpool to win:

There's a lot of off-field drama in the build-up to this match, with the Scouse vultures circling high above an unhappy Alexander Isak. Liverpool also snatched one of Newcastle's top striker targets, Hugo Ekitike, before the season. Why all of this attention on the strikers? The Reds have far more goal-scoring threats in their XI heading into this match. I simply do not know where the Toons' goals will come from, so I'm riding with the reigning champions.

🔮 Expert Premier League picks

💰 Soccer betting odds pages

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission