NFL Odds Week 7: Lines, Spreads & Totals for Every Game

📊 NFL odds Week 7, 2025

The NFL odds for Week 7 are via bet365.

Our NFL picks are loaded up for another week, and we have 15 games to choose from with only the Buffalo Bills and Baltimore Ravens on a bye.

• The Thursday Night Football odds highlight an AFC North rivalry, with the Steelers a 4.5-point road favorite at the Bengals (8:15 p.m. ET, Prime Video)
• The league wraps up its London games on Sunday with the Rams a 3.5-point betting favorite at Wembley Stadium (9:30 a.m. ET, NFL Network)
• The Falcons and 49ers clash to wrap up Sunday's action, with the Sunday Night Football odds showing the 49ers as the 4.5-point betting favorite (8:20 p.m. ET, NBC)
• The Monday Night Football odds again treat us to a doubleheader:
• The Lions are a 4.5-point home betting favorite against the visiting Buccaneers (7 p.m. ET, ABC/ESPN)
• The Seahawks are a 2.5-point betting favorite as they host the Texans (10 p.m. ET, ESPN)
• The week's biggest spread at open: Chiefs -10.5 vs. Raiders
• The week's biggest total at open: 53.5 points for Buccaneers vs. Lions on Monday Night Football

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🏈 Steelers vs. Bengals odds: Thursday Night Football

• Kickoff: 8:15 p.m. ET from Paycor Stadium (Cincinnati)
• How to watch: Prime Video

🏈 Rams vs. Jaguars odds: NFL London Game

• Kickoff: 9:30 a.m. ET from Wembley Stadium (London)
• How to watch: NFL Network

🏈 Falcons vs. 49ers odds: Sunday Night Football

• Kickoff: 8:20 p.m. ET from Levi's Stadium (Santa Clara, Calif.)
• How to watch: NBC

🏈 Buccaneers vs. Lions odds: Monday Night Football

• Kickoff: 7 p.m. ET from Ford Field (Detroit)
• How to watch: ESPN/ABC

🏈 Texans vs. Seahawks odds: Monday Night Football

• Kickoff: 10 p.m. ET from Lumen Field (Seattle)
• How to watch: ABC

🔢 NFL Week 7 odds and lines

There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.

❓NFL odds FAQs

Who's playing on prime time in Week 7?

The week opens with the Steelers vs. Bengals on Thursday Night Football. Sunday features the third and final London game, with the Rams vs. Jaguars clash at Wembley Stadium. Sunday Night Football wraps up the day with the 49ers and Falcons. Another Monday Night Football doubleheader is on the docket, with the Buccaneers vs. the Lions and the Texans vs. the Seahawks.

How do NFL spread odds work?

When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.

How do NFL moneyline odds work?

When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.

Where can I find the NFL betting odds?

Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.