NFL Odds Week 4: Lines, Spreads & Totals for Every Game
📊 NFL odds Week 4, 2025
The NFL odds for Week 4 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Seahawks vs. Cardinals (TNF) | Cardinals -2.5 | Seahawks +115 / Cardinals -135 | 44 (-110/-110) |
| Vikings vs. Steelers (from Dublin) | Steelers -1.5 | Vikings +105 / Steelers -125 | 41 (-110/-110) |
| Panthers vs. Patriots | Patriots -5.5 | Panthers +210 / Patriots -260 | 45.5 (-110/-110) |
| Browns vs. Lions | Lions -10 | Browns +390 / Lions -525 | 46.5 (-110/-110) |
| Chargers vs. Giants | Giants +5.5 | Chargers -250 / Giants +205 | 45.5 (-110/-110) |
| Saints vs. Bills | Bills -14.5 | Saints +650 / Bills -1000 | 47.5 (-110/-110) |
| Eagles vs. Buccaneers | Buccaneers +2.5 | Eagles -140 / Buccaneers +120 | 45.5 (-110/-110) |
| Titans vs. Texans | Texans -7 | Titans +265 / Texans -330 | 40.5 (-110/-110) |
| Commanders vs. Falcons | Falcons +1.5 | Commanders -125 / Falcons +105 | 45.5 (-110/-100) |
| Colts vs. Rams | Rams -4.5 | Colts +185 / Rams -225 | 46.5 (-110/-110) |
| Jaguars vs. 49ers | 49ers -3 | Jaguars +150 / 49ers -180 | 44.5 (-110/-110) |
| Ravens vs. Chiefs | Chiefs +2.5 | Ravens -140 / Chiefs +120 | 48.5 (-110/-110) |
| Bears vs. Raiders | Raiders -1.5 | Bears +105 / Raiders -125 | 46.5 (-110/-110) |
| Packers vs. Cowboys (SNF) | Cowboys +4.5 | Packers -225 / Cowboys +185 | 49 (-110/-110) |
| Jets vs. Dolphins (MNF) | Dolphins -2.5 | Jets +115 / Dolphins -135 | 44.5 (-110/-110) |
| Bengals vs. Broncos (MNF) | Broncos -6.5 | Bengals +225 / Broncos -275 | 44.5 (-110/-110) |
Our NFL picks are piling up as the season presses on. Week 4 gives us our first international game from across the pond, as the league heads to Dublin.
- An NFC West showdown is featured in the Thursday Night Football odds, and it could be a tight game, with the Cardinals the 2.5-point betting favorite over the Seahawks ahead of kickoff at 8:15 p.m. ET (Prime Video) on Sept. 25
- The league's first overseas game of the season opens Sunday action as the Steelers are a 1.5-point betting favorite over the Vikings from Dublin, a 9:30 a.m. ET kickoff (NFL Network)
- The Sunday Night Football odds should see an offensive explosion, with the Packers (-4.5) and Cowboys listed as the week's highest betting total (49 points); kickoff is 8:20 p.m. ET (NBC)
- The Monday Night Football odds give us our second doubleheader of the season
- The Dolphins are a 2.5-point home betting favorite against the visiting Jets in an AFC East tilt at 7:15 p.m. ET (ESPN)
- The Broncos are a 6.5-point home betting favorite against the visiting Bengals in the nightcap, kicking off at 8:15 p.m. ET (ABC)
🏈 Seahawks vs. Cardinals odds: Thursday Night Football
- Kickoff: 8:15 p.m. ET from State Farm Stadium (Glendale, Ariz.)
- How to watch: Prime Video
🏈 Vikings vs. Steelers odds: NFL Dublin Game
- Kickoff: 9:30 a.m. ET from Croke Park (Dublin)
- How to watch: NFL Network
🏈 Packers vs. Cowboys odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from AT&T Stadium (Arlington, Texas)
- How to watch: NBC
🏈 Jets vs. Dolphins odds: Monday Night Football
- Kickoff: 7:15 p.m. ET from Hard Rock Stadium (Miami Gardens, Fla.)
- How to watch: ESPN
🏈 Bengals vs. Broncos odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Empower Field at Mile High (Denver)
- How to watch: ABC
🔢 NFL Week 4 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓NFL odds FAQs
Who's playing on prime time in Week 4?
The Seahawks visit the Cardinals on Thursday Night Football, while the Cowboys host the Packers on Sunday Night Football. Additionally, we have two Monday Night Football games: the Jets at the Dolphins and the Bengals at the Broncos. We also have an International Series game, with the Vikings and Steelers clashing in Dublin on Sunday morning.
How do NFL spread odds work?
When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do NFL moneyline odds work?
When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the NFL betting odds?
Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
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