NFL Odds, Spreads, and Totals: Betting Lines for Every Week 4 Game
📊 NFL odds Week 4, 2025
The NFL odds for Week 4 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Seahawks 23, Cardinals 20 | Seahawks -1.5 | Seahawks -125 / Cardinals +105 | 43.5 (-110/-110) |
| Vikings vs. Steelers (from Dublin) | Steelers +2.5 | Vikings -150 / Steelers +125 | 40.5 (-110/-110) |
| Panthers vs. Patriots | Patriots -5.5 | Panthers +200 / Patriots -245 | 43 (-110/-110) |
| Browns vs. Lions | Lions -10 | Browns +400 / Lions -550 | 44.5 (-110/-110) |
| Chargers vs. Giants | Giants +6.5 | Chargers -310 / Giants +250 | 43.5 (-110/-110) |
| Saints vs. Bills | Bills -15.5 | Saints +900 / Bills -1600 | 48 (-110/-110) |
| Eagles vs. Buccaneers | Buccaneers +3.5 | Eagles -200 / Buccaneers +165 | 43.5 (-110/-110) |
| Titans vs. Texans | Texans -7 | Titans +290 / Texans -370 | 38.5 (-110/-110) |
| Commanders vs. Falcons | Falcons +1 | Commanders -115 / Falcons -105 | 45 (-110/-100) |
| Colts vs. Rams | Rams -3.5 | Colts +160 / Rams -190 | 49.5 (-110/-110) |
| Jaguars vs. 49ers | 49ers -3 | Jaguars +150 / 49ers -180 | 47 (-110/-110) |
| Ravens vs. Chiefs | Chiefs +2.5 | Ravens -150 / Chiefs +125 | 48.5 (-110/-110) |
| Bears vs. Raiders | Raiders -1 | Bears -105 / Raiders -115 | 47.5 (-110/-110) |
| Packers vs. Cowboys (SNF) | Cowboys +6.5 | Packers -350 / Cowboys +275 | 47.5 (-110/-110) |
| Jets vs. Dolphins (MNF) | Dolphins -3 | Jets +125 / Dolphins -150 | 45 (-110/-110) |
| Bengals vs. Broncos (MNF) | Broncos -7.5 | Bengals +320 / Broncos -400 | 44 (-110/-110) |
Our NFL picks are piling up as we're just hours away from Week 4 starting.
- The league's first overseas game of the season opens Sunday action as the Vikings are a 2.5-point betting favorite over the Steelers from Dublin, a 9:30 a.m. ET kickoff (NFL Network)
- The Sunday Night Football odds should see an offensive explosion, with the Packers (-6.5) and Cowboys listed as one of the week's highest betting totals (47.5 points); kickoff is 8:20 p.m. ET (NBC) as Micah Parsons returns to Dallas
- The Monday Night Football odds give us our second doubleheader of the season
- The Dolphins are a 3-point home betting favorite against the visiting Jets in an AFC East tilt at 7:15 p.m. ET (ESPN)
- The Broncos are a 7.5-point home betting favorite against the visiting Bengals in the nightcap, kicking off at 8:15 p.m. ET (ABC)
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↕️ Week 4 biggest line movement
The line movements for Week 4, based on last week's action and injuries, have been some of the smallest we've seen all season. But we have a few reactionary line movements to work with, as seen below:
- The Cardinals dropped from a 2.5-point betting favorite to just 1 point following the loss of running back James Conner for the season, and the Seahawks' commanding victory over the Saints
- The Steelers moved from -1.5 to +2.5 points against the Vikings, the biggest move of the week, following a strong defensive performance and potential returns to the offensive line (LT Justin Skule, C Ryan Kelly)
- The Lions dipped -10 to -8.5, and the total from 47 to 45.5, against the Browns despite a big MNF win - the moves follow the Browns stifling the Packers for the season's biggest upset to date
- The Bills moved from -14.5 to -16.5 against the Saints, the biggest spread of the week, following another dominant Week 3 performance coupled with the Saints looking like the Saints
- The Rams moved from -5 to -3.5 following another strong showing from the Colts, while the total grew from 46.5 to 49
- The Packers moved from -4.5 to -7 against the Cowboys despite a shocking loss to the Browns, a reflection of the Cowboys play and the loss of WR CeeDee Lamb
🏈 Vikings vs. Steelers odds: NFL Dublin Game
- Kickoff: 9:30 a.m. ET from Croke Park (Dublin)
- How to watch: NFL Network
- Early Vikings vs. Steelers prediction: Vikings -1.5
🏈 Packers vs. Cowboys odds: Sunday Night Football
- Kickoff: 8:20 p.m. ET from AT&T Stadium (Arlington, Texas)
- How to watch: NBC
- Early Packers vs. Cowboys prediction: Packers -5.5
🏈 Jets vs. Dolphins odds: Monday Night Football
- Kickoff: 7:15 p.m. ET from Hard Rock Stadium (Miami Gardens, Fla.)
- How to watch: ESPN
- Early Jets vs. Dolphins prediction: Under 44.5
🏈 Bengals vs. Broncos odds: Monday Night Football
- Kickoff: 8:15 p.m. ET from Empower Field at Mile High (Denver)
- How to watch: ABC
- Early Bengals vs. Broncos prediction: Under 45.5
🔢 NFL Week 4 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line. The closer you wait until kickoff to make your NFL picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
❓NFL odds FAQs
Who's playing on prime time in Week 4?
The Seahawks visit the Cardinals on Thursday Night Football, while the Cowboys host the Packers on Sunday Night Football. Additionally, we have two Monday Night Football games: the Jets at the Dolphins and the Bengals at the Broncos. We also have an International Series game, with the Vikings and Steelers clashing in Dublin on Sunday morning.
How do NFL spread odds work?
When betting on the NFL, the favorite needs to win by a certain number of points to cover the "point spread" - also known as the betting line. Conversely, the underdog needs to lose by fewer than the points displayed in the spread or win outright to cash. For example, a 3-point favorite would need to win by more than a field goal to reward bettors.
How do NFL moneyline odds work?
When betting on the NFL, the underdog will have the "longer" odds and is typically priced at "plus-money" odds that indicate the profit on a $100 bet. For example, a team with +150 odds would turn a $100 bet into a $150 profit - or a $10 bet into a $15 profit - according to our odds converter.
Where can I find the NFL betting odds?
Shop around our best NFL betting sites to find the best odds for your college football picks. Our best sports betting sites for all sports include BetMGM, bet365, Caesars, FanDuel, and DraftKings.
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