NFL Odds & Week 18 Schedule | Betting Lines, Spreads and Totals for Every Game
NFL odds Week 18, 2025
The NFL odds for Week 18 are via bet365.
| Game | Spread | Moneyline | Over/Under |
|---|---|---|---|
| Panthers vs. Buccaneers (Saturday) | Buccaneers -3 | CAR +140 / TB -165 | 43.5 |
| Seahawks vs. 49ers (Saturday) | 49ers -1 | SEA -110 / SF -110 | 49.5 |
| Browns vs. Bengals | Bengals -7.5 | CLE +280 / CIN -360 | 44.5 |
| Cowboys vs. Giants | Giants +5.5 | DAL -250 / NYG +205 | 52.5 |
| Packers vs. Vikings | Vikings -6.5 | GB +245 / MIN -305 | 37 |
| Colts vs. Texans | Texans -10 | IND +400 / HOU -550 | 40 |
| Saints vs. Falcons | Falcons -2.5 | NO +125 / ATL -150 | 43.5 |
| Titans vs. Jaguars | Jaguars -10.5 | TEN +425 / JAX -575 | 47 |
| Cardinals vs. Rams | Rams -9.5 | ARI +375 / LAR -500 | 47.5 |
| Lions vs. Bears | Bears -2.5 | DET +125 / CHI -150 | 49.5 |
| Chiefs vs. Raiders | Raiders +6 | KC -310 / LV +250 | 35.5 |
| Chargers vs. Broncos | Broncos -7.5 | LAC +275 / DEN -350 | 39 |
| Dolphins vs. Patriots | Patriots -10 | MIA +425 / NE -575 | 45.5 |
| Jets vs. Bills | Bills -11.5 | NYJ +450 / BUF -600 | 39.5 |
| Commanders vs. Eagles | Eagles -8.5 | WSH +320 / PHI -400 | 42.5 |
| Ravens vs. Steelers (SNF) | Steelers +3 | BAL -185 / PIT +155 | 41 |
Our NFL picks will be locked and loaded for Week 18 as we get ready for the season's final week.
- We have two games on Saturday with division titles on the line:
- The Bucs are a 3-point betting favorite over the visiting Panthers to capture the NFC South (Raymond James Stadium, 4:30 p.m. ET, ABC/ESPN)
- The 49ers are a 1-point betting favorite over the Seahawks to claim the NFC West (Levi's Stadium, 8 p.m. ET, ABC/ESPN)
- Sunday's action wraps with the Ravens a 3-point road betting favorite over the Pittsburgh Steelers per the Sunday Night Football odds (Acrisure Stadium, 8:20 p.m. ET, NBC/Peacock)
Panthers vs. Buccaneers odds: NFC South title game
- Kickoff: 4:30 p.m. ET from Raymond James Stadium (Tampa, Fla.)
- How to watch: ABC/ESPN
- Panthers vs. Buccaneers predictions
Seahawks vs. 49ers: NFC West title game
- Kickoff: 8 p.m. ET from Levi's Stadium (Santa Clara, Calif.)
- How to watch: ABC/ESPN
- Seahawks vs. 49ers predictions
Ravens vs. Steelers odds: Battle for the AFC North
- Kickoff: 8:20 p.m. ET from Acrisure Stadium (Pittsburgh)
- How to watch: NBC/Peacock
- Ravens vs. Steelers predictions
NFL Week 18 odds and lines
There's an advantage to betting early NFL odds when attempting to beat the closing line with your NFL Week 18 predictions. The closer you wait until kickoff to make your picks, the harder it becomes to identify edges and secure the best price on most sides or totals.
Who's playing on prime time in Week 18?
We have three prime-time games in Week 18, with divisions on the line. The Buccaneers host the Panthers for the NFC South on Saturday at 4:30 p.m. ET, and the 49ers finish the day against the visiting Seahawks to claim the NFC West at 8 p.m. ET. The regular season wraps with AFC North foes clashing for the division as the Pittsburgh Steelers host the Baltimore Ravens at 8:29 p.m. ET
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