NFL Predictions Week 17: Best Bets & Odds for Every Game This Week
Last Updated: December 22, 2025 6:00 AM EST β’ 4 minute read X Social Google News Link
With just two weeks left in the regular season, our NFL predictions for Week 17 break down all 16 matchups this week starting with a tripleheader on Christmas Day with two games on Saturday, too. Bookmark this page and check back often as we'll be updating it throughout the week with our best ATS picks, player prop bets, touchdown scorer predictions, and more for every game this week.
π NFL predictions for Week 17
Don't miss the rest of our NFL picks for every game this season.
- Early Cowboys vs. Commanders prediction
- Cowboys vs. Commanders prediction
- Cowboys vs. Commanders player props
- Cowboys vs. Commanders same-game parlay
- Cowboys vs. Commanders anytime touchdown scorer predictions
- Early Lions vs. Vikings prediction
- Lions vs. Vikings prediction
- Lions vs. Vikings player props
- Lions vs. Vikings same-game parlay
- Lions vs. Vikings anytime touchdown scorer predictions
- Early Broncos vs. Chiefs prediction
- Broncos vs. Chiefs prediction
- Broncos vs. Chiefs player props
- Broncos vs. Chiefs same-game parlay
- Broncos vs. Chiefs anytime touchdown scorer predictions
- Early Texans vs. Chargers prediction
- Texans vs. Chargers prediction
- Texans vs. Chargers player props
- Texans vs. Chargers same-game parlay
- Texans vs. Chargers anytime touchdown scorer predictions
- Early Ravens vs. Packers prediction
- Ravens vs. Packers prediction
- Ravens vs. Packers player props
- Ravens vs. Packers same-game parlay
- Ravens vs. Packers anytime touchdown scorer predictions
- Steelers vs. Browns player props
- Jaguars vs. Colts player props
- Buccaneers vs. Dolphins player props
- Patriots vs. Jets player props
- Seahawks vs. Panthers player props
- Eagles vs. Bills player props
- Eagles vs. Bills anytime touchdown scorer predictions
- Early Bears vs. 49ers prediction
- Bears vs. 49ers prediction
- Bears vs. 49ers player props
- Bears vs. 49ers same-game parlay
- Bears vs. 49ers anytime touchdown scorer predictions
- Bears vs. 49ers first touchdown scorer predictions
- Bears vs. 49ers weather report
- Bears vs. 49ers expert picks
- Early Rams vs. Falcons prediction
- Rams vs. Falcons prediction
- Rams vs. Falcons player props
- Rams vs. Falcons same-game parlay
- Rams vs. Falcons anytime touchdown scorer predictions
- Rams vs. Falcons first touchdown scorer predictions
- Rams vs. Falcons weather report
- Rams vs. Falcons expert picks
π° NFL odds & expert picks: Thursday Night Football
See the latest Thursday Night Football odds and our best TNF predictions.
Cowboys vs. Commanders odds
- Date: Thursday, Dec. 25
- Kickoff: 1 p.m. ET
- Location: Northwest Stadium (Landover, Md.)
- TV: FOX
Early Cowboys vs. Commanders prediction
🤠 Cowboys -5.5 (-110)
Neither of these teams have anything to play for in terms of postseason stakes, but the Commanders are in especially rough shape with their top two quarterbacks injured and their defense playing like one of the worst units in football. I don't love to lay points on bad teams, but you'd have to pay me to back Washington right now.
Lions vs. Vikings odds
- Date: Thursday, Dec. 25
- Kickoff: 4:30 p.m. ET
- Location: U.S. Bank Stadium (Minneapolis)
- TV: FOX
Early Lions vs. Vikings prediction
🟣 Vikings +6 (-110)
The Lions desperately need a win to keep their playoff hopes alive, though that's been the case for weeks and it hasn't made much of a difference for this beleaguered group. I expect Minnesota's defense to frustrate Jared Goff enough to at least keep this one close.
Broncos vs. Chiefs odds
- Date: Thursday, Dec. 25
- Kickoff: 8:15 p.m. ET
- Location: GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
- TV: NBC
Early Broncos vs. Chiefs prediction
🐎 Broncos -12.5 (-112)
Remember when the Broncos destroyed the Chiefs last year behind a backup quarterback in a game that didn't matter for Kansas City? Fast forward nearly 12 months and Denver is even better, K.C. is worse, and the stakes are as high as ever for the visitors. Regardless of who plays QB for the Chiefs, I'm on the Broncos.
π° NFL odds & expert picks: Saturday
Live NFL odds for every Week 17 game from our best NFL betting sites.
Texans vs. Chargers odds
- Date: Saturday, Dec. 27
- Kickoff: 4:30 p.m. ET
- Location: SoFi Stadium (Inglewood, Calif.)
- TV: CBS
Early Texans vs. Chargers prediction
🐂 Texans +1.5 (-115)
The Texans' offense is clearly an imperfect unit, but their defense is so staggeringly good that I'm surprised we're still catching points with Houston so regularly - especially against a team with such glaring offensive line woes like the Chargers. I fully expect the Texans to win outright.
Ravens vs. Packers odds
- Date: Saturday, Dec. 27
- Kickoff: 8 p.m. ET
- Location: Lambeau Field (Green Bay, Wis.)
- TV: NBC
Early Ravens vs. Packers prediction
🧀 Packers -2.5 (-105)
Two teams walk into a must-win spot in Week 17 with an injured quarterback and a defense falling apart at the seams. Fortunately for the Packers, backup QB Malik Willis looked incredible in relief last week for Green Bay, which is playing better football than Baltimore after last week's blown lead against the Patriots.
π° NFL odds & expert picks: Sunday
Patriots vs. Jets odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: MetLife Stadium (East Rutherford, N.J.)
- TV: CBS
Early Patriots vs. Jets prediction
🪖 Patriots -12.5 (-114)
It's tough not to buy into the Patriots right now with Drake Maye playing at an MVP level, especially ahead of a matchup with an overmatched Jets defense that can't generate pressure or force turnovers. As long as Breece Hall doesn't go nuclear, New England should win comfortably.
Buccaneers vs. Dolphins odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: Hard Rock Stadium (Miami Gardens, Fla.)
- TV: FOX
Early Buccaneers vs. Dolphins prediction
🐬 Dolphins +5.5 (-110)
After a four-game win streak to potentially turn their season around, the Dolphins have lost two straight and turned to backup QB Quinn Ewers for the rest of the season. That still isn't enough for me to buy the Bucs, who are in a similar tailspin amid a three-game skid. I'll gladly take the points in this sad in-state duel.
Steelers vs. Browns odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: Huntington Bank Field (Cleveland)
- TV: CBS
Early Steelers vs. Browns prediction
🏗️ Steelers -4.5 (-108)
The Steelers haven't always looked the part en route to a likely AFC North title, but they continue to stack wins behind Aaron Rodgers' late-career heroics and a tenacious defense even with T.J. Watt sidelined. Pittsburgh can clinch the division with a win Sunday, and I don't expect the Browns' offense to have enough answers to keep this one close.
Cardinals vs. Bengals odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: Paycor Stadium (Cincinnati)
- TV: CBS
Early Cardinals vs. Bengals prediction
🐯 Bengals -7 (-110)
Even with the playoffs out of the picture, Joe Burrow and the Bengals' offense continue to put up incredible performances on a near-weekly basis to close out the regular season. The Cardinals look closer to true white-flag status, so I wouldn't be surprised if this one gets ugly by halftime.
Saints vs. Titans odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: Nissan Stadium (Nashville, Tenn.)
- TV: CBS
Early Saints vs. Titans prediction
⚜️ Saints -2.5 (-114)
The secret is out about these scrappy Saints in Year 1 for head coach Kellen Moore and quarterback Tyler Shough, but I still see value in laying the cheap price on the road against the Titans, who have feasted on some of the NFL's worst offenses for their only wins this year.
Jaguars vs. Colts odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: Lucas Oil Stadium (Indianapolis)
- TV: CBS
Early Jaguars vs. Colts prediction
🐆 Jaguars -6.5 (-114)
I'm shocked this line is still under a touchdown after the Jaguars' statement win over the top-seeded Broncos last week and the Colts still relying on a 44-year-old Philip Rivers under center. I'd bet this early in the week in case the line creeps past 7 and doesn't return.
Seahawks vs. Panthers odds
- Date: Sunday, Dec. 28
- Kickoff: 1 p.m. ET
- Location: Bank of America Stadium (Charlotte, N.C.)
- TV: FOX
Early Seahawks vs. Panthers prediction
🟢 Seahawks -7 (-110)
The Panthers have a tendency to strike when you least expect it, so tread cautiously when laying the big number, but Bryce Young also has a tendency to implode against tough defenses after impressive starts. This feels like a classic spot for Carolina to wilt offensively before a true do-or-die game next week in Tampa Bay.
Giants vs. Raiders odds
- Date: Sunday, Dec. 28
- Kickoff: 4:05 p.m. ET
- Location: Allegiant Stadium (Las Vegas)
- TV: CBS
Early Giants vs. Raiders prediction
🏴☠️ Raiders +1.5 (-115)
Both of these teams have lost nine consecutive games entering Week 17, but the Raiders showed a little more life last week in a loss to the Texans, while the Giants finished with 13 net passing yards. I simply can't in good conscience lay points on the road with a team coming off such an abject disaster offensively.
Eagles vs. Bills odds
- Date: Sunday, Dec. 28
- Kickoff: 4:25 p.m. ET
- Location: Highmark Stadium (Orchard Park, N.Y.)
- TV: FOX
Early Eagles vs. Bills prediction
🦬 Bills -2.5 (-110)
Two of the NFL's most dangerous and flawed teams meet in Week 17 in a game that clearly holds more stakes for Buffalo than it does for Philadelphia. While the Eagles tend to play the best teams well, Josh Allen is rediscovering his MVP form down the stretch, which has me leaning toward the Bills early in the week.
π° NFL odds & expert picks: Sunday Night Football
See the latest Sunday Night Football odds and our best TNF predictions.
Bears vs. 49ers odds
- Date: Sunday, Dec. 28
- Kickoff: 8:20 p.m. ET
- Location: Leviβs Stadium (Santa Clara, Calif.)
- TV: NBC
Early Bears vs. 49ers prediction
🐻 Bears +2.5 (+102)
I believe in what I've seen from this Bears offense in its first year under Ben Johnson, especially with Caleb Williams taking care of the football and the run game profiling as the best in the league. The 49ers keep winning despite never feeling like an elite group on paper - I'm bet that luck runs short on Sunday Night Football.
π° NFL odds & expert picks: Monday Night Football
See the latest Monday Night Football odds and our best TNF predictions.
Rams vs. Falcons odds
- Date: Monday, Dec. 29
- Kickoff: 8:15 p.m. ET
- Location: Mercedes-Benz Stadium (Atlanta)
- TV: ESPN
Early Rams vs. Falcons prediction
🐏 Rams -8 (-110)
The Rams lost the opportunity to control their own destiny with that bitter overtime loss last week to the Seahawks, but they still have a chance for the No. 1 seed if they take care of business the rest of the way. The Falcons have struggled all year against truly elite teams - this one should not be a fair fight.
π‘ NFL expert picks for Week 17
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
- NFL picks against the spread Week 17
- NFL player props for Christmas Day
- NFL anytime touchdown scorer predictions for Christmas Day
- NFL anytime touchdown scorer parlay for Christmas Day
- NFL best bets for Christmas Day
- NFL predictions for Christmas Day
- NFL parlay picks for Christmas Day
- NFL AI predictions Week 17
- NFL weather report Week 17
- NFL upset picks Week 17
- NFL player props Week 17
- NFL best bets Week 17
- NFL anytime touchdown scorer predictions Week 17
- NFL first touchdown scorer predictions Week 17
- NFL 2+ touchdown scorer predictions Week 17
- NFL anytime touchdown scorer parlay Week 17
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