NFL Player Props Week 4: Best Prop Odds, Bets & Expert Picks

Last Updated: September 26, 2025 12:00 PM EDT • 5 minute read X Social Google News Link

Another full slate of football is upon us, and I'm diving into 10 of my best NFL player prop bets as our NFL picks continue to build your bankroll throughout the season. We are 15-14 on the year, now let's take it to another level.
My NFL player props include Saquon Barkley, Daniel Jones, Jahmyr Gibbs, and more as I roll through my wagers for this week. Let's cash together all season long and fire up our NFL predictions for Week 4.
🏈 Best NFL player props: Week 4
NFL player prop bet odds subject to changes
- Amon-Ra St. Brown anytime touchdown scorer (+130 at FanDuel) ⭐⭐⭐
- Derrick Henry Over 82.5 rushing yards (-110 at BetMGM) ⭐⭐⭐⭐
- Puka Nacua Over 7.5 receptions (-125 at FanDuel) ⭐⭐⭐⭐
- Josh Allen Over 217.5 passing yards (-115 at BetMGM) ⭐⭐⭐⭐
- Spencer Rattler Over 206.5 passing yards (-115 at BetMGM) ⭐⭐⭐
- Cam Ward Over 188.5 passing yards (-120 at FanDuel) ⭐⭐⭐⭐
- Bucky Irving Over 63.5 rushing yards (-110 at BetMGM) ⭐⭐⭐⭐
- Saquon Barkley anytime touchdown scorer (-135 at FanDuel) ⭐⭐⭐⭐
- Jahmyr Gibbs Under 64.5 rushing yards (-118 at FanDuel ) ⭐⭐⭐⭐
- Daniel Jones Under 217.5 passing yards (-115 at DraftKings) ⭐⭐⭐⭐
💰 Best NFL Week 4 player prop bets: My best bets
Our NFL player prop odds tool shows the best odds for every market across legal sportsbooks in your area
⬇️ Jahmyr Gibbs Under 64.5 rushing yards (-118) ⭐⭐⭐⭐

Welcome to one of my favorite Week 4 player props.
Yes, Jahmyr Gibbs is one of the best running backs in football. However, he has the stiffest test of his season going up against the Cleveland Browns' NFL-best run defense. Cleveland is giving up just 57.3 yards per game on the ground, and with Gibbs and David Montgomery already sharing carries, the volume to get over this number is going to be difficult to come by.
At -118 betting odds, you have an implied probability of 54.1% that this bet cashes. You'll take home $8.47 on a $10 wager here.
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⬆️ Puka Nacua Over 7.5 receptions (-125) ⭐⭐⭐⭐

Death, taxes, and Puca Nacua Over receptions.
We are going back to the well after yet another week of Puka going over this number. The NFL prop betting sites have finally caught on, moving the line from his usual 6.5 receptions to 7.5, but that doesn't matter to me - the No. 1 wideout is averaging 10 receptions per game, leaving us plenty of space on this wager.
If you're feeling risky, play the 8.5 receptions here at plus-money - Nacua is coming off a 15-target game, and we should see the same output against an Indianapolis Colts team that can put up points.
⬆️ Derrick Henry Over 81.5 rushing yards (-110) ⭐⭐⭐⭐

Henry, they're saying you're washed; they're saying you can't hold on to the ball. What do you have for me in Week 4?
The King gets back on track in a big way against the Kansas City Chiefs in the 4 p.m. ET slate. Kansas City just allowed Cam Skattebo to average six yards per carry in Week 3, and now has an angry Henry to deal with.
For the first time in his career, he has something to prove.
I wouldn't play this number past 84.5, which is what you get at DraftKings. Instead, run over to BetMGM to make this play (52.4% implied probability), which will net you $9.09 in profit on a $10 bet.
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⬇️ Daniel Jones Under 217.5 passing yards (-115) ⭐⭐⭐⭐

Yes, I know I'm playing with fire here - but it's Daniel Jones' first real test of the season, and it's coming against the sixth-best passing defense in the NFL.
The Rams have held Jalen Hurts to 226 passing yards, Cam Ward to 175, and C.J. Stroud to 188. Meanwhile, Jones has ripped apart the Miami Dolphins (the worst-ranked pass defense in the NFL), the Denver Broncos (I'll give him his flowers here), and the Tennessee Titans.
I'm backing the Rams to come up big for us in this spot, and for Jones and the Colts to lean heavily on Offensive Player of the Year odds favorite Jonathan Taylor.
I'd bet this number down to 210.5, but wouldn't touch it past there. At -115 betting odds, you have an implied probability of 53.5% that this hits. A $10 wager nets you $8.70 in profit.
🔮 NFL expert picks: Week 4
- NFL AI predictions
- NFL player props today
- NFL moneyline picks
- NFL predictions Week 4
❓ NFL betting FAQs
What are the best NFL player props for Week 4?
My best NFL player props for Week 4 include fading Daniel Jones, riding Derrick Henry after his fumble streak, and sticking with Puka Nacua to catch eight balls.
How do NFL player props work?
Player props are wagers on individual performances rather than the outcome of the game. Common props include passing yards, rushing yards, receiving yards, and touchdown scorers. For example, if a QB’s passing yards line is set at 250.5, you can bet the Over (251-plus yards) or Under (250 or fewer yards). You can also bet on if a specific player will score a touchdown in the entire game, the first or last touchdown, and more NFL odds.
You can determine the payouts and implied probabilities for any wager - or convert odds to different formats - with our odds converter.
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