NFL Picks Against the Spread: Week 10 Best Bets & ATS Predictions for Every Game

My NFL picks against the spread for Week 10 focus on the Philadelphia Eagles, Denver Broncos, and Buffalo Bills while providing a prediction for every game on the slate. 

The Los Angeles Rams and Seattle Seahawks are the best ATS teams thus far, sharing 6-2 records. Betting favorites are 74-59-2, and I'm sporting a 58-47 ATS record. The picks below are part of our Week 10 NFL predictions. 

🏈 NFL picks against the spread: Week 10 ATS predictions

NFL picks against the spread based on the latest NFL odds and subject to change; pick confidence based on a 1-to-5-star scale.

💰 My best Week 10 ATS picks

🦅 Eagles (+2.5) vs. Packers ⭐⭐⭐⭐

The Packers too readily switch between Dr. Jekyll and Mr. Hyde, with no warning of which to expect. The Eagles, meanwhile, were rolling in the two previous games before their bye week. There's always a chance the bye week will disrupt the momentum they've gained, but an additional week's rest is never taken for granted. 

And it should help against a Packers team that looked dysfunctional on the offensive side of the ball. Philadelphia is 5-3 ATS and has won three of four road games, with the ghastly outlier against the New York Giants the only exception. They are 2-0 ATS as the road betting underdog since the start of last season. 

All of the best sports betting sites have the Eagles at +2.5, with Caesars' -109 odds offering the best value. A winning $10 bet will profit $9.17. Phil Wood is aligned with this pick via his early Eagles vs. Packers prediction.

🐎 Broncos (-9) vs. Raiders ⭐⭐⭐⭐

After winning six games in a row, the Broncos are rightfully among the Super Bowl odds contenders. I also backed Sean Payton's team in my Raiders vs. Broncos prediction, citing numerous reasons, including the Raiders' woeful road form.

While usually competitive at Allegiant Stadium, the Raiders lost the last three games on enemy turf by an average of 27.3 points. 

Denver has outscored its opponents 95-52 since the fourth quarter of the epic comeback win over the New York Giants in Week 7. They have the decisive advantage on both sides of the ball and should make life even more difficult for Geno Smith than the Kansas City Chiefs did at Arrowhead. 

And while Brock Bowers was rampant upon his return to the lineup for the Raiders, accumulating 127 receiving yards, the Broncos' defense should do a much better job at mitigating his influence than Jacksonville could. As far as trends go, the Broncos won by at least 10 in both previous meetings. Denver also features as Mike Spector's safest NFL survivor pool pick of the week.

BetMGM, bet365, and Caesars have the Broncos at -9, while FanDuel and DraftKings have them at -9.5. bet365's -105 odds are marginally better than Caesars' -108. A winning $10 bet at bet365 will yield a $9.52 profit.

🦬 Bills (-9.5) vs. Dolphins ⭐⭐⭐⭐

The Bills enjoyed their most complete performance against the Chiefs in Week 9, showcasing most of the reasons why they're the Super Bowl odds favorites.

While there's always a chance of a letdown in the subsequent game, Buffalo's defense is getting healthy, and its youthful, inexperienced starters are growing in confidence.

NFL MVP odds favorite Josh Allen has looked fresh since the team's Week 7 bye week, and he will face a Miami Dolphins team with the fourth-worst defensive DVOA. I predicted the Dolphins players would quit on Mike McDaniel in Week 8 against the Atlanta Falcons.

While that was incorrect, it looked as though a full-blown capitulation was on the cards in Week 9 when they were thrashed 28-6 by the Baltimore Ravens at home, and on prime time. At 2-7, and with almost no hope of making the playoffs, I can't see them going to war for their embattled head coach.

The Bills are the 9.5-point betting favorite across the best sports betting apps, with the odds ranging from -109 to -111. The -109 odds at Caesars will profit $9.17 on a winning $10 bet.