Panthers vs. 49ers Player Props: Monday Night Football Prop Bets Tonight

The Carolina Panthers travel to face the San Francisco 49ers tonight as Week 12 in the NFL concludes with Monday Night Football, and my best Panthers vs. 49ers player props will get you set.

My NFL predictions for Week 12 dig into whether Panthers QB Bryce Young can add to last week's strong showing while also highlighting a couple of players on the home side you might want to target. San Francisco is a 7.5-point betting favorite ahead of kickoff from Levi's Stadium in Santa Clara, Calif., at 8:15 p.m. ET (ESPN). 

✅ Panthers vs. 49ers player prop bets

See all of our experts' NFL picks for Week 12 based on the latest NFL odds. FanDuel

💰 Best Monday Night Football player props

⬆️ Christian McCaffrey player prop: Over 71.5 rushing yards (-114) ⭐⭐⭐⭐⭐

Carolina has a middling run defense, and McCaffrey may just get the volume we're looking for if the 49ers are sailing through this game in the fourth quarter. For his part, he's gone over this number twice in the last three games, averaging 6.2 yards per carry against a run defense in Arizona allowing just one more yard per game than the Panthers do.

FanDuel has the best betting odds on this one at -114, which means you have a 53.27% chance of your play cashing. Fire McCaffrey up as part of your best Panthers vs. 49ers player props for Monday Night Football.

If you're looking for another player who might be poised to feast on this Panthers defense, Gary Pearson breaks down his favorite mismatch in his Panthers vs. 49ers prediction.

⬇️ Brock Purdy player prop: Under 250.5 passing yards (-114) ⭐⭐⭐⭐

Carolina has a sneaky good pass defense, allowing just 212 passing yards per game. Brock Purdy is still getting his feet underneath him after coming back from injury, completing 19 of 26 passes in Week 11 for 200 yards against a bad Arizona team. Look for the 49ers to run their offense through McCaffrey for the majority of the night, and for Purdy to ultimately run out of time (and attempts) to go over this number. It helps us that the wideouts in San Fran are nothing to write home about. 

You're getting the best price at FanDuel for this prop, and you're also getting some value, as I'd price this play closer to -120.

⬆️ Bryce Young player prop: Over 204.5 passing yards (-114) ⭐⭐⭐⭐

Bryce Young is in a good spot to fly over this number once more. San Francisco owns one of the worst pass defenses in football, allowing 249.5 pass yards per game - good for 28th in the NFL. While Rico Dowdle will get his carries, this number is just far too low for me to think Young won't do enough to cash this for us. Especially if the narrative unfolds as I expect - with the 49ers holding a late lead.

I'd price this play closer to -125 than the -114 betting odds we're getting at FanDuel. Don't be shy, let's hold hands to the bank on Monday Night Football.

🎟️ Panthers vs. 49ers most-bet props and touchdown scorers

Here are the most-bet props in the hours before kickoff, via BetMGM.

1. Tetairoa McMillan Over 62.5 receiving yards
2. Christian McCaffrey Under 18.5 rushing attempts
3. Brian Robinson Jr. Over 21.5 rushing yards
4. Rico Dowdle Under 75.5 rushing yards
5. Christian McCaffrey Over 43.5 receiving yards

And here are the most-bet touchdown scorers.

1. George Kittle (+130)
2. Xavier Legette (+450)
3. Christian McCaffrey (-325)
4. Jauan Jennings (+200)
5. Brian Robinson Jr. (+475)

📺 How to watch Monday Night Football: Panthers vs. 49ers

• Date: Monday, Nov. 24
• Kickoff: 8:15 p.m. ET
• Location: Levi's Stadium (Santa Clara, Calif.)
• TV: ESPN

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