Panthers vs. 49ers Player Props for Monday Night Football: NFL Week 12

Carolina travels to San Francisco for Monday Night Football, and I'm dropping my best Panthers vs. 49ers player props to get you set for the 8:15 p.m. ET kickoff (ESPN) at Levi's Stadium as part of our NFL predictions for Week 12.

The 49ers come into this one as 7.5-point favorites - but can Bryce Young build off his 448-yard, three-touchdown performance? Let's dive in.

✅ Panthers vs. 49ers player prop bets

See all of our experts' NFL picks for Week 12 based on the latest NFL odds. FanDuel

💰 Best Monday Night Football player props

⬆️ Christian McCaffrey player prop: Over 71.5 rushing yards (-114) ⭐⭐⭐⭐⭐

Carolina has a middling run defense, and McCaffrey may just get the volume we're looking for if the 49ers are sailing through this game in the fourth quarter. For his part, he's gone over this number twice in the last three games, averaging 6.2 yards per carry against a run defense in Arizona allowing just one more yard per game than the Panthers do.

FanDuel has the best betting odds on this one at -114, which means you have a 53.27% chance of your play cashing. Fire McCaffrey up as part of your best Panthers vs. 49ers player props for Monday Night Football.

⬇️ Brock Purdy player prop: Under 250.5 passing yards (-114) ⭐⭐⭐⭐

Carolina has a sneaky good pass defense, allowing just 212 passing yards per game. Brock Purdy is still getting his feet underneath him after coming back from injury, completing 19 of 26 passes in Week 11 for 200 yards against a bad Arizona team. Look for the 49ers to run their offense through McCaffrey for the majority of the night, and for Purdy to ultimately run out of time (and attempts) to go over this number. It helps us that the wideouts in San Fran are nothing to write home about. 

You're getting the best price at FanDuel for this prop, and you're also getting some value, as I'd price this play closer to -120.

⬆️ Bryce Young player prop: Over 204.5 passing yards (-114) ⭐⭐⭐⭐

Bryce Young is in a good spot to fly over this number once more. San Francisco owns one of the worst pass defenses in football, allowing 249.5 pass yards per game - good for 28th in the NFL. While Rico Dowdle will get his carries, this number is just far too low for me to think Young won't do enough to cash this for us. Especially if the narrative unfolds as I expect - with the 49ers holding a late lead.

I'd price this play closer to -125 than the -114 betting odds we're getting at FanDuel. Don't be shy, let's hold hands to the bank on Monday Night Football.

📺 How to watch Monday Night Football: Panthers vs. 49ers

• Date: Monday, November 24, 2025
• Kickoff: 8:15 p.m. ET
• Location: Levi's Stadium (San Francisco, Calif.)
• TV: ESPN