Panthers vs. 49ers Best Bets: Our Staff Expert Picks for Monday Night Football

NFL Week 12 concludes tonight with the Carolina Panthers (6-5) and San Francisco 49ers (7-4) facing off on Monday Night Football (8:15 p.m. ET, ESPN) from Levi's Stadium in Santa Clara, Calif. We've gathered our Panthers vs. 49ers best bets from our NFL staff with their MNF expert picks as part of our NFL Week 12 predictions.

🏈 Panthers vs. 49ers best bets & MNF expert picks

See all of our NFL picks for every game based on the latest NFL odds.

🔮 Panthers vs. 49ers prediction

Even amid a rash of injuries, the 49ers have weathered the storm to remain in the thick of the NFC playoff race with roughly a third of the season left. And our NFL expert Gary Pearson expects San Francisco to take care of business at home tonight.

Pearson is laying the points on the home betting favorites to cover the spread against the Panthers, whose offense is simply too consistent for Pearson's taste. He breaks down his best bets in every key market in his Panthers vs. 49ers prediction.

🔥 Panthers vs. 49ers player props

Our NFL expert Dustin Saracini is breaking down the player props market from every angle for this game - and he's circling Christian McCaffrey as a lynchpin for the 49ers' attack tonight on Monday Night Football.

Saracini is backing the All-Pro rusher to make an impact on the ground as his most confident five-star play in his Panthers vs. 49ers player props. He also breaks down both passing offenses in great detail as he highlights his best Brock Purdy player props for the 49ers QB and his best Bryce Young player props for the Panthers passer.

💪 Panthers vs. 49ers anytime TD pick

Saracini is also offering his best anytime TD picks for tonight's matchup at Levi's Stadium, which could be impacted by "patchy fog" according to the latest Panthers vs. 49ers weather report. That could lead to some extra work for both teams' running backs and most reliable targets in the passing game.

That's exactly where Saracini is focused with his touchdown picks, as he's shining a spotlight on Panthers breakout rusher Rico Dowdle as his lone five-star bet tonight. He's also betting on arguably the best two receivers in the game with his anytime touchdown scorer predictions for Monday Night Football.

🥇 Panthers vs. 49ers first TD pick

Our NFL expert Sean Tomlinson is back on the first TD beat for Monday Night Football, and as longtime readers have come to expect, he has his eyes on a star tight end and a long-shot receiver as part of his best bets to score the first touchdown.

Much like Saracini's anytime TD picks, Tomlinson has zeroed in on 49ers tight end George Kittle and Panthers wide receiver Tetairoa McMillan with two of his best value bets to score early. But he's also targeting a 25/1 long shot tonight with his first touchdown scorer predictions for Panthers vs. 49ers.

🚀 Panthers vs. 49ers same-game parlay

What would Monday Night Football be without a little sweat? Our NFL expert Brenden Schaeffer has put together another same-game parlay for prime time as he looks to turn a small wager into a big payday - this time targeting Bryce Young and the underdog Panthers to keep things close in a game that CMC shines as a receiver. He breaks down his full logic for this SGP with his Panthers vs. 49ers same-game parlay for this MNF clash.

📺 How to watch Monday Night Football: Panthers vs. 49ers

• Date: Monday, Nov. 24
• Kickoff: 8:15 p.m. ET
• Location: Levi's Stadium (Santa Clara, Calif.)
• TV: ESPN