Kansas City Chiefs 2025 Schedule, Odds & Predictions: AI Picks for Every Game

We're breaking down everything you need to know about the Chiefs, including odds and projections for all 17 games.

Last updated: May 15, 2025 8:46 AM EDT • 4 min read

Kansas City Chiefs 2025 Schedule: Game-by-Game Odds, Predictions & AI Picks — Pictured: Kansas City Chiefs quarterback Patrick Mahomes (15) greets tight end Travis Kelce (87). Photo by Denny Medley / Imagn Images.

We're breaking down the Kansas City Chiefs schedule, odds, and predictions for the 2025 NFL season following the official schedule release. The Jaguars are projected to win 7.5 games across our best sports betting sites, and we're offering our 2025 win-loss predictions with AI picks for all 17 games.

📅 Kansas City Chiefs 2025 schedule & odds for every game

Odds via DraftKings as of Thursday, May 15. All times listed in Eastern Time.

Week	Date	Opponent	Favorite
1	Friday, Sept. 5 @ 8 PM	at Chargers	Chiefs -3
2	Sunday, Sept. 14 @ 4:25 PM	vs. Eagles	Chiefs -1.5
3	Sunday, Sept. 21 @ 8:20 PM	at Giants	Chiefs -6.5
4	Sunday, Sept. 28 @ 4:25 PM	vs. Ravens	Chiefs -1.5
5	Monday, Oct. 6 @ 8:15 PM	at Jaguars	Chiefs -4.5
6	Sunday, Oct. 12 @ 8:20 PM	vs. Lions	Chiefs -3
7	Sunday, Oct. 19 @ 1 PM	vs. Raiders	Chiefs -9.5
8	Monday, Oct. 27 @ 8:15 PM	vs. Commanders	Chiefs -3.5
9	Sunday, Nov. 2 @ 4:25 PM	at Bills	Bills -2.5
10	BYE WEEK	-	-
11	Sunday, Nov. 16 @ 4:25 PM	at Broncos	Chiefs -1.5
12	Sunday, Nov. 23 @ 1 PM	vs. Colts	Chiefs -9.5
13	Thursday, Nov. 27 @ 4:30 PM	at Cowboys	Chiefs -4.5
14	Sunday, Dec. 7 @ 8:20 PM	vs. Texans	Chiefs -6.5
15	Sunday, Dec. 14 @ 1 PM	vs. Chargers	Chiefs -4.5
16	Sunday, Dec. 21 @ 1 PM	at Titans	Chiefs -7
17	Thursday, Dec. 25 @ 8:15 PM	vs. Broncos	Chiefs -4.5
18	TBD	at Raiders	Chiefs -6

👉 Check out the full 2025 NFL schedule with odds for every game.

📊 Kansas City Chiefs odds to win Super Bowl & best futures bets

🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area!

💰 Kansas City Chiefs O/U win total

Latest NFL win totals via BetMGM as of Thursday, May 16.

Over 11.5 wins: -102 (bet $10 to win $9.80)
Under 11.5 wins: -118 (bet $10 to win $8.47)

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🔮 Kansas City Chiefs 2025 predictions: Game-by-game picks & final record

Check out our 2025 NFL season predictions for projected standings, playoff results, and award winners - and a breakdown of how our AI model predicts every game.

🤖 Kansas City Chiefs 2025 AI projections

Week 1: Chiefs 30, Chargers 27 ✅
Week 2: Chiefs 33, Eagles 31 ✅
Week 3: Chiefs 26, Giants 19 ✅
Week 4: Chiefs 29, Ravens 23 ✅
Week 5: Chiefs 34, Jaguars 28 ✅
Week 6: Chiefs 30, Lions 27 ✅
Week 7: Chiefs 34, Raiders 17 ✅
Week 8: Chiefs 34, Commanders 20 ✅
Week 9: Chiefs 31, Bills 28 ✅
Week 11: Chiefs 31, Broncos 23 ✅
Week 12: Chiefs 30, Colts 17 ✅
Week 13: Cowboys 28, Chiefs 27 ❌
Week 14: Chiefs 35, Texans 20 ✅
Week 15: Chiefs 30, Chargers 24 ✅
Week 16: Chiefs 33, Titans 20 ✅
Week 17: Chiefs 34, Broncos 20 ✅
Week 18: Chiefs 28, Raiders 21 ✅

🏈 Kansas City Chiefs 2025 record prediction

Projected win-loss record: 16-1

🔮 2025 NFL season previews & predictions

Following the NFL schedule release, we broke down the odds for every game and asked AI to predict every game (and more). Below are our team-by-team schedules, odds, and predictions for Week 1 through Week 18.

Buffalo Bills	Miami Dolphins	New York Jets	New England Patriots
Baltimore Ravens	Pittsburgh Steelers	Cincinnati Bengals	Cleveland Browns
Houston Texans	Indianapolis Colts	Jacksonville Jaguars	Tennessee Titans
Kansas City Chiefs	Los Angeles Chargers	Denver Broncos	Las Vegas Raiders
Philadelphia Eagles	Washington Commanders	Dallas Cowboys	New York Giants
Detroit Lions	Minnesota Vikings	Green Bay Packers	Chicago Bears
Tampa Bay Buccaneers	Atlanta Falcons	Carolina Panthers	New Orleans Saints
Los Angeles Rams	Seattle Seahawks	Arizona Cardinals	San Francisco 49ers

💵 Best NFL betting sites

Ready to bet on the NFL this season? Check out our best NFL betting sites and the best sportsbook promos for the 2025-26 NFL season:

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written By:
C Jackson Cowart

C Jackson Cowart is a publishing editor and lead writer for Sportsbook Review. An award-winning writer, reporter, and editor with a decade of sports media experience, "C-Jax" has worked with ESPN, Forbes, theScore, and various daily newspapers before joining the Sportsbook Review team. He's a proud graduate of the University of North Carolina, where he served as a beat writer for the Tar Heels' championship run through the NCAA men's basketball tournament in 2017. Jackson has spent the last five years covering sports betting as a predictive analyst, features writer, and industry reporter. Since joining the team in 2023, he's played a key role in Sportsbook Review's coverage of the Super Bowl, March Madness, and NBA playoffs while serving as the lead writer for the growing WNBA and NASCAR betting scenes. Though he's cashed some big bets over the years -- including Lamar Jackson to win MVP (twice) -- he's still haunted by enough second-place bet slips to wallpaper his home office. While Jackson is a committed "process over results" bettor with a keen eye for advanced stats and subtle bias in futures markets, he also embraces sports betting as a vehicle for entertainment and personal investment. He's written about everything from hot dogs to groundhogs and still hasn't forgiven his "inside source" for a sabotaged bet on the Gatorade color in Super Bowl LV.