Detroit Lions 2025 Schedule, Odds & Predictions: Training Camp Updates Ahead of Week 1

Here's everything you need to know about the Lions ahead of Week 1, including odds and projections for all 17 games and the latest news out of training camp.
Detroit Lions 2025 Schedule: Odds, Predictions & Training Camp Updates
Pictured: Running back Jahmyr Gibbs (26) runs the ball as we're breaking down the Detroit Lions schedule, odds, and predictions. Photo by Lon Horwedel via Imagn Images.

We're breaking down the Detroit Lions schedule, odds, and predictions for the 2025 NFL season ahead of Week 1, along with updates from the team's training camp. The Lions are projected to win 10.5 games across our best sports betting sites, and we're offering our 2025 win-loss predictions with AI picks for all 17 games.

📅 Detroit Lions 2025 schedule & odds for every game

Odds via DraftKings as of Tuesday, Aug. 19. All times listed in Eastern Time.

Week Date Opponent Favorite
1 Sunday, Sept. 7 @ 4:25 PM at Packers Packers -1.5
2 Sunday, Sept. 14 @ 1 PM vs. Bears Lions -4.5
3 Monday, Sept. 22 @ 8:15 PM at Ravens Ravens -3.5
4 Sunday, Sept. 28 @ 1 PM vs. Browns Lions -10.5
5 Sunday, Oct. 5 @ 4:25 PM at Bengals Lions -1.5
6 Sunday, Oct. 12 @ 8:20 PM at Chiefs Chiefs -3
7 Monday, Oct. 20 @ 7 PM vs. Buccaneers Lions -3.5
8 BYE WEEK - -
9 Sunday, Nov. 2 @ 1 PM vs. Vikings Lions -4.5
10 Sunday, Nov. 9 @ 4:25 PM at Commanders Commanders -1.5
11 Sunday, Nov. 16 @ 8:20 PM at Eagles Eagles -3.5
12 Sunday, Nov. 23 @ 1 PM vs. Giants Lions -8.5
13 Thursday, Nov. 27 @ 1 PM vs. Packers Lions -2.5
14 Thursday, Dec. 4 @ 8:15 PM vs. Cowboys Lions -6
15 Sunday, Dec. 14 @ 4:25 PM at Rams Lions -1.5
16 Sunday, Dec. 21 @ 4:25 PM vs. Steelers Lions -6
17 Thursday, Dec. 25 @ 4:30 PM at Vikings Lions -2.5
18 TBD at Bears Lions -1.5

👉 Check out the full 2025 NFL schedule with odds for every game.

📊 Detroit Lions odds to win Super Bowl & best futures bets

🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area!

  • Detroit has new offensive and defensive coordinators this season - John Morton and Kelvin Sheppard, respectively. The Lions had two of the league's best in those positions the last few years (Ben Johnson and Aaron Glenn), and how effective the new OC and DC are will be crucial to whether Detroit can stay atop the NFC North.
  • Star pass-rusher Aidan Hutchinson is fully back after finishing last season on IR with a major leg injury.
  • Cornerback Ennis Rakestraw Jr. is out for the 2025 season after undergoing shoulder injury.

💰 Detroit Lions O/U win total

Latest NFL win totals via BetMGM as of Tuesday, Aug. 19.

  • Over 10.5 wins: +110 (bet $10 to win $11)
  • Under 10.5 wins: -135 (bet $10 to win $7.41)

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📈 Odds movement

The Lions are still projected to win 10.5 games but are now favored to go Under that number at the best sports betting apps. Detroit's win total O/U initially opened at even odds.

🔮 Detroit Lions 2025 predictions: Game-by-game picks & final record

Check out our 2025 NFL season predictions for projected standings, playoff results, and award winners - and a breakdown of how our AI model predicts every game.

🤖 Detroit Lions 2025 AI projections

  • Week 1: Lions 28, Packers 24 ✅
  • Week 2: Lions 31, Bears 20 ✅
  • Week 3: Ravens 34, Lions 28 ❌
  • Week 4: Lions 27, Browns 19 ✅
  • Week 5: Bengals 28, Lions 27 ❌
  • Week 6: Chiefs 30, Lions 27 ❌
  • Week 7: Lions 28, Buccaneers 23 ✅
  • Week 9: Lions 29, Vikings 21 ✅
  • Week 10: Commanders 31, Lions 28 ❌
  • Week 11: Lions 31, Eagles 30 ✅
  • Week 12: Lions 27, Giants 21 ✅
  • Week 13: Lions 30, Packers 26 ✅
  • Week 14: Lions 34, Cowboys 30 ✅
  • Week 15: Rams 27, Lions 26 ❌
  • Week 16: Steelers 24, Lions 21 ❌
  • Week 17: Lions 26, Vikings 23 ✅
  • Week 18: Bears 27, Lions 24 ❌

🏈 Detroit Lions 2025 record prediction

  • Projected win-loss record: 10-7

🦁 Detroit Lions Week 1 odds at Packers

The Lions visit the Green Bay Packers at Lambeau Field on Sunday, Sept. 7. Kickoff is set for 4:25 p.m. ET. Detroit opened as a 1.5-point underdog, and that line remained as of Aug. 19.

Detroit has beat Green Bay in five of their last six matchups over the past three seasons, but the Lions are underdogs to start the 2025 season as the Packers look to win the NFC North for the first time since 2021.

🔮 2025 NFL season previews & predictions

Following the NFL schedule release, we broke down the odds for every game and asked AI to predict every game (and more). Below are our team-by-team schedules, odds, and predictions for Week 1 through Week 18.

💵 Best NFL betting sites

Ready to bet on the NFL this season? Check out our best NFL betting sites and the best sportsbook promos for the 2025-26 NFL season:

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