Best NFL Long Shot Parlay Today: Week 10 Moneyline Picks for Every Game
Last Updated: November 9, 2025 9:10 AM EST • 3 minute read X Social Google News Link
My best NFL long shot parlays for Week 10 headline a moneyline prediction for every game on the forthcoming slate, where a $10 bet will profit $2,750 if every leg hits.
These Week 10 NFL predictions are accompanied by five- and seven-leg plays, with the latter an extension of the former.
💰 My best NFL parlay picks for Week 10
Our NFL player prop odds tool shows the best NFL odds for every market across legal sportsbooks in your area.
This week's five-leg parlay includes a moneyline pick, a spread, and three player props. I'm backing the Jacksonville Jaguars to beat the Houston Texans on the road, thanks mainly to C.J. Stroud not featuring. Trevor Lawrence and Co. beat the Texans at home with Stroud playing.
My spread pick sees the Cleveland Browns, the 2-point betting favorite, beating a woeful New York Jets team that just traded two of their best defensive players. Cleveland has played a few good games this season, and its defense should give the Jets' offense fits.
Two of the three player props feature a pair of the most clutch QBs entering Week 10. I'm fading Daniel Jones' pass attempts, backing him to toss 32 or fewer passes in Germany against an Atlanta Falcons team that allows the fewest passing yards per game. Our Mike Spector made the same pick in his NFL best bets for Week 10.
Correlating with that pick is my assertion that Jonathan Taylor is in for a big outing, which I previewed in my Falcons vs. Colts prediction. With the Tampa Bay Buccaneers' defense allowing at least 296 passing yards in two of the last four games, Drake Maye should throw for at least 236 passing yards.
Finally, expect James Cook to cook in Miami against a middling Dolphins run defense. A winning $10 bet will profit almost $227.
🎯 My best NFL long-shot parlay for Week 10
I've added two legs from the first play, making this a seven-leg parlay that will profit over $805 if it hits. The first addition is for Matthew Stafford to throw at least 261 passing yards.
He hit the Over on this total in three of four home games, with the only exception coming against the Texans, one of the best passing defenses. Stafford accumulated 389 passing yards in the previous loss to the San Francisco 49ers.
My final leg predicts Breece Hall will go Under his projected 60.5-yard rushing total. He didn't seem impressed about not being traded and is up against a Cleveland Browns team with the best defensive rush unit.
🚀 My best NFL moneyline parlay picks for every game
This week's mega-moneyline parlay backs two underdogs, with the Philadelphia Eagles upsetting the Green Bay Packers and the Pittsburgh Steelers winning at SoFi Stadium against the Los Angeles Chargers.
The Packers' offense struggled mightily at home against the Carolina Panthers last week, and the Eagles are well-rested coming off their bye week. The Steelers' defense had their best game last week against the Indianapolis Colts, and I expect them to make life uncomfortable for Justin Herbert, whose offensive line remains depleted.
If every moneyline prediction is correct, a $10 bet will profit $2,750.
💡 NFL expert picks for Week 10
Follow all of our NFL analysis for Week 10 throughout the week.
- NFL picks against the spread Week 10
- NFL QB clutch player ratings Week 10
- NFL survivor picks Week 10
- NFL AI predictions Week 10
- NFL weather report Week 10
- NFL upset picks Week 10
- NFL player props Week 10
- NFL expert picks Week 10
- NFL best bets Week 10
- NFL moneyline picks Week 10
- NFL anytime touchdown scorer predictions Week 10
- NFL first touchdown scorer predictions Week 10
- NFL 2+ touchdown scorer predictions Week 10
- NFL anytime touchdown scorer parlay Week 10
- NFL long-shot parlay Week 10
📃 Affiliate disclosure
Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)
Gary Pearson X social