Arizona Cardinals 2025 Schedule, Odds & Predictions: Training Camp Updates Ahead of Week 1
We're breaking down the Arizona Cardinals schedule, odds, and predictions for the 2025 NFL season ahead of Week 1, along with updates from the team's training camp. The Cardinals are projected to win 8.5 games across our best sports betting sites, and we're offering our 2025 win-loss predictions with AI picks for all 17 games.
📅 Arizona Cardinals 2025 schedule & odds for every game
Odds via DraftKings as of Monday, Aug. 25. All times listed in Eastern Time.
| Week | Date | Opponent | Favorite |
|---|---|---|---|
| 1 | Sunday, Sept. 7 @ 1 PM | at Saints | Cardinals -6 |
| 2 | Sunday, Sept. 14 @ 4:05 PM | vs. Panthers | Cardinals -4.5 |
| 3 | Sunday, Sept. 21 @ 4:25 PM | at 49ers | 49ers -3.5 |
| 4 | Thursday, Sept. 25 @ 8:15 PM | vs. Seahawks | Cardinals -2.5 |
| 5 | Sunday, Oct. 5 @ 4:05 PM | vs. Titans | Cardinals -5.5 |
| 6 | Sunday, Oct. 12 @ 1 PM | at Colts | Cardinals -1.5 |
| 7 | Sunday, Oct. 19 @ 4:25 PM | vs. Packers | Packers -1.5 |
| 8 | BYE WEEK | - | - |
| 9 | Monday, Nov. 3 @ 8:15 PM | at Cowboys | Cowboys -1.5 |
| 10 | Sunday, Nov. 9 @ 4:05 PM | at Seahawks | Seahawks -1.5 |
| 11 | Sunday, Nov. 16 @ 4:05 PM | vs. 49ers | 49ers -1.5 |
| 12 | Sunday, Nov. 23 @ 4:05 PM | vs. Jaguars | Cardinals -3 |
| 13 | Sunday, Nov. 30 @ 1 PM | at Buccaneers | Buccaneers -3.5 |
| 14 | Sunday, Dec. 7 @ 4:25 PM | vs. Rams | Rams -1.5 |
| 15 | Sunday, Dec. 14 @ 1 PM | at Texans | Texans -2.5 |
| 16 | Sunday, Dec. 21 @ 4:05 PM | vs. Falcons | Cardinals -3.5 |
| 17 | TBD | at Bengals | Bengals -3.5 |
| 18 | TBD | at Rams | Rams -4.5 |
👉 Check out the full 2025 NFL schedule with odds for every game.
📊 Arizona Cardinals odds to win Super Bowl & best futures bets
🔎 Our NFL player prop odds tool can help you find the best NFL odds across legal sportsbooks in your area!
🏕️ Training camp updates
- Quarterback Kyler Murray says his knee is feeling back to normal after tearing his ACL late in 2022. One of the league's top rushing QBs says he wants to run more in 2025.
- Sophomore wide receiver Marvin Harrison Jr. was expected to be a star from Day 1 in the NFL. Although he had a productive rookie year, fans and analysts are wondering if this will be season the top talent meets those lofty expectations.
- Wideout Michael Wilson was in concussion protocol early in training camp.
- Cornerback Will Johnson, a second-round pick after he was once thought to be a top-10 prospect, has impressed all throughout the summer ahead of his rookie season.
💰 Arizona Cardinals O/U win total
Latest NFL win totals via BetMGM as of Monday, Aug. 25
- Over 8.5 wins: -125 (bet $10 to win $8)
- Under 8.5 wins: +105 (bet $10 to win $10.50)
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🔮 Arizona Cardinals 2025 predictions: Game-by-game picks & final record
Check out our 2025 NFL season predictions for projected standings, playoff results, and award winners - and a breakdown of how our AI model predicts every game.
🤖 Arizona Cardinals 2025 AI projections
- Week 1: Saints 26, Cardinals 21 ❌
- Week 2: Panthers 26, Cardinals 23 ❌
- Week 3: 49ers 34, Cardinals 20 ❌
- Week 4: Seahawks 27, Cardinals 24 ❌
- Week 5: Cardinals 23, Titans 16 ✅
- Week 6: Colts 28, Cardinals 19 ❌
- Week 7: Packers 26, Cardinals 22 ❌
- Week 9: Cowboys 24, Cardinals 17 ❌
- Week 10: Seahawks 27, Cardinals 22 ❌
- Week 11: 49ers 33, Cardinals 20 ❌
- Week 12: Jaguars 26, Cardinals 24 ❌
- Week 13: Buccaneers 27, Cardinals 21 ❌
- Week 14: Rams 30, Cardinals 23 ❌
- Week 15: Texans 24, Cardinals 20 ❌
- Week 16: Falcons 28, Cardinals 20 ❌
- Week 17: Bengals 27, Cardinals 16 ❌
- Week 18: Rams 26, Cardinals 23 ❌
🏈 Arizona Cardinals 2025 record prediction
- Projected win-loss record: 1-16
🐦 Arizona Cardinals Week 1 odds at Saints
The Cardinals visit the New Orleans Saints at Caesars Superdome on Sunday, Sept. 7. Kickoff is set for 1 p.m. ET. Arizona opened as a 3.5-point favorite, but that line lengthened to Cardinals -6 as of Aug. 25.
New Orleans is projected to be among the league's worst teams in 2025, with a young and unproven quarterback room being a major reason why. The Cardinals and Saints have not matched up since 2022.
🔮 2025 NFL season previews & predictions
Following the NFL schedule release, we broke down the odds for every game and asked AI to predict every game (and more). Below are our team-by-team schedules, odds, and predictions for Week 1 through Week 18.
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💵 Best NFL betting sites
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