Eagles vs. Bills Anytime Touchdown Scorer Predictions Today | Eagles vs. Bills TD Picks
Last Updated: December 28, 2025 10:24 AM EST • 3 minute read X Social Google News Link
My Eagles vs. Bills anytime touchdown scorer predictions target three plus-money TD picks from the NFL's game of the day, played today at 4:25 p.m. ET at Highmark Stadium in Orchard Park, N.Y. (FOX). The Bills are the 2.5-point betting favorite with an Over/Under of 44.5. Both teams are playoff-bound but continue to fight for seeding.
The Eagles have secured the NFC East title. The Bills enter Week 17 second in the AFC East but have a shot to win the division.
🏈 Anytime touchdown scorer predictions: Eagles vs. Bills
See the latest NFL odds and our experts' NFL picks for every game this season.
| Player | Best odds | Confidence |
|---|---|---|
| A.J. Brown, WR, Eagles | +170 via FanDuel | ⭐⭐⭐⭐⭐ |
| Josh Allen, QB, Bills | +116 via Caesars | ⭐⭐⭐⭐⭐ |
| Dawson Knox, TE, Bills | +295 via Caesars | ⭐⭐⭐⭐ |
💰 Best Eagles vs. Bills anytime touchdown scorer bet
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A.J. Brown, WR, Eagles (+170) ⭐⭐⭐⭐⭐
These odds are a steal as the Eagles remain motivated to secure the best possible seed in the NFC playoffs. We're getting higher odds for A.J. Brown to score his eighth touchdown of the season after he missed practice early in the week following a dental procedure, but he returned to the practice field Friday.
The standout wideout was targeted 10 or more times in five of his past six games, with the one exception being the Eagles' 31-0 rout of the Raiders two weeks ago.
💰️ Big day for Jalen Hurts
Our Dustin Saracini has to the Over on QB Jalen Hurts' passing yards with his NFL player props.
🙌 More Eagles vs. Bills touchdown scorer picks
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
Josh Allen, QB, Bills (+116) ⭐⭐⭐⭐⭐
Josh Allen failed to score a rushing touchdown in each of his last two games, but he totaled 18 attempts and 65 yards. He enters Week 17 with 12 rushing touchdowns on the season and is three shy of matching a career high.
The narrow spread and the cold and snow from our NFL weather forecast should see Allen keeping the ball himself even more than usual. The Eagles have allowed four rushing touchdowns to opposing QBs this season, and I expect the Tush Push to be deployed regularly on both sides this afternoon.
Our Mike Spector also backs Allen to score with his Eagles vs. Bills player props.
Dawson Knox, TE, Bills (+295) ⭐⭐⭐⭐
Though Dawson Knox is the clear No. 2 on the Bills' tight end depth chart, he leads Dalton Kincaid 10 to eight in red-zone targets through Week 16. He caught just five of those 10 looks, but has scored three touchdowns inside the opponents' 20-yard line.
Similar to the Allen anytime touchdown scorer prediction, I expect this to be a battle of the trenches throughout the entire game, with both teams competing for ball control through long, time-consuming drives. The 6-foot-4 tight end has long been a go-to option for Allen near the goal line.
Saracini offers up a full card of anytime touchdown scorer predictions for Week 17.
🚀 Eagles vs. Bills anytime touchdown scorer parlay
See all of our NFL touchdown props for Week 17 and more.
💵 Eagles vs. Bills touchdown parlay
- A.J. Brown, WR, Eagles (+170) ⭐⭐⭐⭐⭐
- Josh Allen, QB, Bills (+116) ⭐⭐⭐⭐⭐
- Dawson Knox, TE, Bills (+295) ⭐⭐⭐⭐
Best SGP odds: +2050 via Caesars ($10 to win $205)
📊 Anytime touchdown scorer odds: Eagles vs. Bills
💡 NFL expert picks for Week 17
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
- NFL picks against the spread Week 17
- NFL AI predictions Week 17
- NFL upset picks Week 17
- NFL weather report Week 17
- NFL player props Week 17
- NFL best bets Week 17
- NFL anytime touchdown scorer predictions Week 17
- NFL first touchdown scorer predictions Week 17
- NFL 2+ touchdown scorer predictions Week 17
- NFL anytime touchdown scorer parlay Week 17
📺 How to watch Eagles vs. Bills
- Date: Sunday, Dec. 28
- Kickoff: 4:25 p.m. ET
- Location: Highmark Stadium (Orchard Park, N.Y.)
- TV: FOX
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