Anytime Touchdown Scorer Predictions 49ers vs. Seahawks: NFL Divisional Round Weekend TD Picks

My best 49ers vs. Seahawks anytime touchdown scorer predictions for tonight's Divisional Round game at Lumen Field in Seattle focus on Jaxon Smith-Njigba, Cooper Kupp, and Kyle Juszczyk. The Seahawks are a 7-point betting favorite ahead of kickoff at 8 p.m. ET (FOX).

These two teams have combined for just four touchdowns in their two meetings this season, which is why two of my three Divisional Round predictions have odds of +300 or more. 

🏈 49ers vs. Seahawks anytime touchdown scorer predictions

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💰 Best 49ers vs. Seahawks anytime touchdown scorer bet: Jaxon Smith-Njigba, WR, Seahawks (+100) ⭐⭐⭐⭐

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Smith-Njigba hasn’t scored in three of his last four games, and he didn’t find the end zone at all against the 49ers this season. However, in two games against the 49ers, he’s caught 15 of 21 targets for 208 yards. 

Smith-Njigba has scored 10 touchdowns this season. Considering the 49ers have allowed at least 84 yards and 13.8 yards per reception to him in both games, it’s clear they don’t have an answer for him.

The 49ers allowed 29 passing touchdowns during the regular season, tied for the 11th-most in the NFL.

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Cooper Kupp, WR, Seahawks (+320) ⭐⭐⭐

Kupp has only caught two touchdowns this season. Yet, while he’s caught 2-of-3 targets in each game against the 49ers, he’s third on the Seahawks in receptions and second in targets and receiving yards.

The former Super Bowl MVP has caught at least two passes in 14 of his 16 games, and he’s averaging 12.6 yards per reception. Not only did the 49ers give up a lot of passing touchdowns this year, but they also finished the regular season allowing 232.4 passing yards per game, the eighth-most in the league.

Kyle Juszczyk, RB, 49ers (+800) ⭐⭐

Juszczyk hasn’t put up big numbers this season, but he’s caught a pass in 16 of his 18 games, and he tied a season-high with four opportunities against the Eagles last week.

George Kittle is out, and I expect Kyle Shanahan to creatively involve players who are generally less active. Juszczyk has caught three of his four targets against the Seahawks this season, including a 25-yarder in Week 1. Last week, he caught all four of his targets for 49 yards, tied for his most receiving yards in a game since 2020. He’s scored twice this year.

🚀 Anytime touchdown scorer parlay for 49ers vs. Seahawks

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📊 49ers vs. Seahawks anytime touchdown scorer odds