49ers vs. Seahawks Expert Picks for Divisional Round: NFL Predictions, Best Bets & Odds

Seattle hosts San Francisco tonight, and I'm breaking down my best 49ers vs. Seahawks expert picks to get you ready for the Divisional Round matchup at 8 p.m. ET (FOX) from Lumen Field in Seattle, as part of our NFL playoff predictions.

The Seahawks enter the game as 7-point betting favorites, we will see if Sam Darnold can finally win a playoff game.

---

🏈 49ers vs. Seahawks expert picks: Divisional Round predictions

See the latest NFL odds and our experts' NFL picks for every game this season.

---

🔮 49ers vs. Seahawks prediction

Seahawks -7 (-114) ⭐⭐⭐⭐

Sean Tomlinson: "One Seahawks weakness is against tight ends, as Seattle has allowed the sixth-most receiving yards to the position. But that'll be difficult to exploit now, and the Seahawks surrendered the second-fewest yards to wide receivers during the regular season."

See Sean Tomlinson's full analysis in his 49ers vs. Seahawks predictions, including his favorite player prop bet and the best betting trends, injury report, and more.

---

🔥 Best 49ers vs. Seahawks player prop pick

Christian McCaffrey Over 50.5 receiving yards (-115) ⭐⭐⭐⭐⭐

Liam Fox: "Seattle allowed the NFL's most targets and receptions to the position, alongside the sixth-most receiving yards. And San Francisco's inefficiency rushing the football has forced McCaffrey into his heaviest workload as a pass-catcher in years."

See Fox's full analysis in his 49ers vs. Seahawks player props, including his best bet for Sam Darnold and Brock Purdy tonight.

---

🙌 Best 49ers vs. Seahawks anytime touchdown scorer pick

Jaxon Smith-Njigba, WR, Seahawks (+100) ⭐⭐⭐⭐

Phil Wood: "Smith-Njigba has scored 10 touchdowns this season. Considering the 49ers have allowed at least 84 yards and 13.8 yards per reception to him in both games, it’s clear they don’t have an answer for him."

See Woods full analysis in his 49ers vs. Seahawks anytime touchdown scorer predictions, including a +800 touchdown scorer. You can follow all of our NFL touchdown props for the biggest games every week.

---

1️⃣ Best 49ers vs. Seahawks first touchdown scorer pick

Zach Charbonnet, RB, Seahawks (+550) ⭐⭐⭐⭐

Phil Wood: "Zach Charbonnet has scored 12 touchdowns this season, and he’s scored first for the Seahawks in both of their games against the 49ers. He leads the Seahawks with 12 touchdowns, and he’s scored in three consecutive games."

See Wood's full analysis in his first touchdown scorer predictions, including a +900 first touchdown pick.

---

🚀 49ers vs. Seahawks same-game parlay

Here's a look at what our NFL expert Phil Wood is betting tonight with his best 49ers vs. Seahawks SGP paying out at +600 odds:

💵 49ers vs. Seahawks SGP bets

• Under 44.5 (-109) ⭐⭐⭐⭐⭐
• Sam Darnold Over 19.5 completions (-112) ⭐⭐⭐⭐
• Christian McCaffrey Over 5.5 receptions (-175) ⭐⭐⭐⭐⭐

Best SGP odds: +600 via DraftKings ($10 to win $60)

See Wood's full analysis in his 49ers vs. Seahawks same-game parlay, you can follow all of our NFL same-game parlay bets for the biggest games every week.

---

📊 49ers vs. Seahawks odds: NFL Wild Card Round

Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.

---

📺 How to watch 49ers vs. Seahawks: NFL Divisional Round

• Date: Saturday, Jan. 17, 2026
• Kickoff: 8 p.m. ET
• Location: Lumen Field (Seattle)
• TV: FOX

---

📃 Affiliate disclosure

Sportsbook Review may receive a commission if you sign up through our links. Not intended for use in MA. Bonuses not applicable in Ontario. 21+ only. (Gambling problem? Call 1-800-GAMBLER)