49ers vs. Eagles Predictions for Wild Card Round | Opening Odds & NFL Playoffs Best Bet
My 49ers vs. Eagles predictions for Sunday's Wild Card Round battle break down the matchup between two teams that have accounted for the last three NFC titles. Kickoff from Lincoln Financial Field is set for 4:30 p.m. ET (FOX).
The Eagles have been bet up to a 4.5-point betting favorite, and my NFL playoff predictions based on the opening odds love this new line even more than the opener.
🏈 Early 49ers vs. Eagles prediction
See the latest NFL odds and our experts' NFL picks for every game this season.
49ers +3.5 (-110) ⭐⭐⭐⭐⭐
While San Francisco may not win this game outright, the 49ers were one of the best teams in football away from home, owning a 7-2 record against the spread on the road. The Philadelphia defense also owns a bottom-10 run-stopping unit, setting Christian McCaffrey up for a big game and keeping his offense in third-and-short situations. If Trent Williams returns, watch out - that defense will be in for a long night in the trenches.
💡 More NFL predictions
Want more NFL betting advice? Check out all of our NFL analysis and expert predictions for every game this season.
📊 Live 49ers vs. Eagles odds: Wild Card Weekend
Our NFL wild-card betting odds provide the updated odds from the best sports betting sites for 49ers vs. Eagles.
49ers vs. Eagles opening odds
- Moneyline: 49ers +165 | Eagles -195
- Spread: 49ers +3.5 (-110) | Eagles -3.5 (-195)
- Over/Under: Over 45.5 (-120) | Under 45.5 (+100)
49ers vs. Eagles line movement
We're seeing 49ers +4.5 across the board as of Tuesday morning, with a majority of bettors (58%) on backing the visitors.
The total has also seen semi-significant movement, dropping from an opening line of 46.5 to as low as 44.5 at DraftKings despite a small majority (53%) on the Over.
📈 49ers vs. Eagles trends & betting notes: Wild Card Round
- 49ers are 7-2 ATS on the road this season
- Eagles give up 124 yards per game on the ground, one of the worst run-stopping units in football
- Eagles are just 4-4 ATS at home this season
- 49ers have the seventh-best total offense over their last three games (351.4 yards per game)
📺 How to watch 49ers vs. Eagles: Wild Card Weekend
- Date: Sunday, Jan. 11, 2026
- Kickoff: 4:30 p.m. ET
- Location: Lincoln Financial Field (Philadelphia)
- TV: FOX
💡 NFL Wild Card Weekend predictions
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