49ers vs. Eagles Prediction, Picks & Best Bets: Wild Card Weekend
The defending champions will begin the postseason leg of their effort to repeat, and they're the increasingly heavier favorites as we make our 49ers vs. Eagles prediction.
The Eagles started the week as the -3.5 betting odds favorite, and that's now widely shifted to -6. But I'm eyeing the underdog Niners as part of our NFL playoff predictions for the wild-card round.
Kickoff is set for 4:30 p.m. ET from Lincoln Financial Field in Philadelphia (FOX).
🏈 49ers vs. Eagles prediction: NFL Wild Card Weekend
See the latest NFL odds and our experts' NFL picks for every game this postseason.
| Predictions | Best odds | Confidence |
|---|---|---|
| 49ers +6 | -108 via Caesars | ⭐⭐⭐⭐ |
| Under 44.5 | -110 via bet365 | ⭐⭐⭐⭐ |
| Dallas Goedert to score | +200 via bet365 | ⭐⭐⭐⭐ |
💰 49ers vs. Eagles best bet: 49ers +6 (-110) ⭐⭐⭐⭐⭐
Follow all of our NFL analysis and betting advice for the 2026 NFL playoffs.
One separator between these teams is run defense, with the 49ers ranking 11th (107.8 yards per game) and the Eagles down in 22nd (124.4 yards).
The Seattle Seahawks just stifled the 49ers' offense while holding San Francisco's running backs to 32 rushing yards, and limiting Christian McCaffrey to a mere 2.9 yards per carry.
That'll be tough to follow, and especially with McCaffrey's versatility. McCaffrey just posted 924 receiving yards, and the Eagles gave up the seventh-most receiving yards to running backs.
We're standing alongside our early 49ers vs. Eagles predictions and backing the Niners.
Score prediction: Eagles 20, 49ers 17
🙌 Best 49ers vs. Eagles touchdown scorer prediction: Dallas Goedert (+200) ⭐⭐⭐⭐⭐
See all of our NFL touchdown props for the 2026 NFL playoffs.
Dallas Goedert is fresh off finishing tied for second leaguewide with 11 receiving touchdowns. It's a mark he hit on only 60 catches and 82 targets, showing that Goedert is a specialized weapon for the Eagles.
He's a sure-handed red-zone magnet, hauling in eight of his nine looks inside the 10-yard line for eight touchdowns. His skill in that area and usage make him the ideal pick against a 49ers defense that finished the regular season tied for the sixth-most touchdowns given up to tight ends, and the unit allowed the ninth-most catches to TEs.
📊 49ers vs. Eagles odds: NFL Wild Card Weekend
Our live 49ers vs. Eagles odds update in real time.
📈 49ers vs. Eagles betting trends: NFL Wild Card Round
| 49ers | Statistic | Eagles |
|---|---|---|
| 12-5 | W-L record | 11-6 |
| 11-6 | ATS record | 10-7 |
| 10-7 | O/U record | 7-10 |
| 5.5 | Yards per play | 5.2 |
| 5.6 | Yards allowed per play | 4.9 |
| -6 | Turnover margin | +6 |
| 4-1 | Last 5 games | 3-2 |
🚑 49ers vs. Eagles latest injuries
🌤️ 49ers vs. Eagles weather: Sunday, 4:30 p.m. ET
Follow our NFL weather report for the latest forecasts for every playoff game.
The weather shouldn't be an overbearing factor, with the forecast calling for an unseasonably warm day by January standards in Philadelphia, with the temperature at kickoff sitting around 41 degrees before falling to about 36. There's also only a 9% chance of precipitation.
The only potential element at play is the wind, which will sit around 15 mph and gust up to 27 mph.
📺 How to watch 49ers vs. Eagles: NFL Wild Card Round
- Date: Sunday, Jan. 11, 2026
- Kickoff: 4:30 p.m. ET
- Location: Lincoln Financial Field (Philadelphia)
- TV: FOX
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