🏀 Ohio State vs. Michigan State Prediction & Odds: College Basketball Picks Today (Feb. 22)
Last Updated: February 22, 2026 9:37 AM EST • 3 minute read X Social Google News Link
Ohio State desperately needs a big road win to improve its NCAA Tournament chances, but No. 15 Michigan State looks to get right after three of its five losses came within the last three weeks. Tipoff from Breslin Center in East Lansing, Mich., is set for 1 p.m. ET (CBS).
The Spartans are a 10-point betting favorite, and my Ohio State vs. Michigan State prediction backs them to earn a much needed victory with huge road tests at Purdue and Indiana looming next week. In addition to an ATS play, I also offer a score prediction and player prop bet.
🏀 Ohio State vs. Michigan State picks & odds today: Feb. 22
See all of our experts' college basketball picks based on the latest college basketball odds; picks rated on a 1-to-5 star confidence scale based on betting value.
| Bet type | Prediction | Units | Confidence |
|---|---|---|---|
| Game prediction | Michigan State -10 (-110) | 1u -> 0.91u | ⭐⭐⭐⭐ |
| Over/Under total | Under 148.5 (-110) | 1u -> 0.91u | ⭐⭐⭐ |
| Player prop bet | Carson Cooper Over 7.5 rebounds (-105) | 1u -> 0.95u | ⭐⭐⭐⭐ |
Total wagered: 3.0 units | Max profit: 2.77 units
💰 Ohio State vs. Michigan State prediction & best bet
Ohio State has not won back-to-back games for over a month, so I am selling high on the Buckeyes following an impressive 17-point home win over Wisconsin.
Meanwhile, Michigan State has played at a top-7 level at Breslin Center, per Bart Torvik. The Spartans also tend to get a better whistle at home, improving from a minus-0.3 free throw rate differential in road games to a plus-12.5 differential in home games.
With the Spartans as high as 10.5-point favorites, I am backing the best number at Caesars.
Score prediction: Michigan State 79, Ohio State 65
🔥 Best Ohio State vs. Michigan State player prop bet
Carson Cooper Over 7.5 rebounds (-105)
In home games, per Bart Torvik, Michigan State is a top-5 defense while owning a plus-17.2 rebounding differential per 100 possessions.
The Spartans are exceptional at forcing jump shots, with 46.5% of their opponents’ field goal attempts coming from 3-point range, which ranks in the top 20 in the country. Ohio State ranks 13th in Big Ten play in percentage of its points coming from 3-point range, so the Buckeyes should struggle offensively while needing to make more shots than usual.
Carson Cooper has grabbed at least seven rebounds in three consecutive games. And the only time he stayed under this projected total was in the last game when he finished with zero offensive rebounds for just the second time in the last 11.
3️⃣ 3-pointers made
Want another prop for this game? My college basketball best bets and predictions today feature a player prop on Bruce Thornton's 3-pointers made
🚀 Ohio State vs. Michigan State same-game parlay
Michigan State has covered 58.3% of its games as a home favorite this season, and 57.1% of its conference games. Meanwhile, the Under has cashed in six of Ohio State’s seven games against ranked opponents. More misses should result in more rebounding opportunities for Carson Cooper as well, who brings a high floor with 7.2 boards per game into this contest.
💵 Ohio State vs. Michigan State SGP picks
- Michigan State -10 (-116)
- Under 148.5 (-110)
- Carson Cooper Over 7.5 rebounds (-105)
Best odds: +594 via bet365 (1u -> 5.94u)
💡 How I'm betting Ohio State vs. Michigan State
Follow all of our college basketball analysis and expert predictions this season.
Ohio State’s only three road wins in conference play have come against teams that entered the weekend in the bottom five of the Big Ten standings (Rutgers, Oregon, and Maryland). With the calendar approaching March, I am backing Tom Izzo to get his team to bounce back from a recent 2-3 stretch and play its best basketball.
Because of each team’s inconsistencies, I am only allocating one unit to each wager, while backing the Over on Carson Cooper’s rebounds supports the wagers on the spread and total.
📊 Live Ohio State vs. Michigan State odds
Most of the top sports betting sites opened slightly lower at Michigan State -9.5, but have since topped out at -10.5. The total has a much wider gap, with O/Us currently ranging between 144.5 at FanDuel and 148.5 at other top sports betting sites.
📈 Ohio State vs. Michigan State betting trends
| Ohio State | Statistic | Michigan State |
|---|---|---|
| 17-9 | W-L record | 21-5 |
| 12-14 | ATS record | 14-12 |
| 12-14 | O/U record | 11-15 |
| 3-2 | Last 5 games | 2-3 |
📺 How to watch Ohio State vs. Michigan State
- Date: Sunday, Feb. 22
- Tipoff: 1 p.m. ET
- Location: Breslin Center (East Lansing, Mich.)
- TV: CBS
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Mike Spector X social