🏀 Iowa State vs. BYU Prediction & Odds: College Basketball Picks Today (Feb. 21)

My Iowa State vs. BYU prediction has the Cyclones winning Saturday night’s matchup.
Iowa State Cyclones guard Tamin Lipsey (3) scores as we break down our Iowa State vs. BYU prediction & odds.
Pictured: Iowa State Cyclones guard Tamin Lipsey (3) scores as we break down our Iowa State vs. BYU prediction & odds. Photo by Reese Strickland-Imagn Images
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College basketball fans have a late Saturday night clash as No. 6 Iowa State and No. 23 BYU battle at 10:30 p.m. ET at the Marriott Center in Provo, Utah, on ESPN.

We have two ranked teams battling it out tonight, and I’ve identified an edge on one side along with a player prop in my Iowa State vs. BYU prediction. Iowa State is a 3.5-point favorite, and the total sits at 154.5.


🏀 Iowa State vs. BYU picks & odds today: Feb. 21

See all of our experts' college basketball picks based on the latest college basketball odds; picks rated on a 1-to-5 star confidence scale based on betting value.

Bet type Prediction Units Confidence
Game prediction Iowa State -3.5 (-102) 1.02u -> 1u  ⭐⭐⭐⭐
Over/Under total Under 154.5 (-110) 0.55u -> 0.5u  ⭐⭐⭐
Player prop bet Tamin Lipsey Over 12.5 Total Points (-125) 0.63u -> 0.5u  ⭐⭐⭐

Total wagered: 2.2 units | Max profit: 2 units


💰 Iowa State vs. BYU prediction & best bet

Iowa State -3.5 (-102)

Iowa State is in a strong position to cover the 3.5-point spread against BYU tonight because of its defensive consistency and ability to control pace. The Cyclones thrive on forcing turnovers and turning defense into easy transition points, which can quickly create separation on the scoreboard.

While BYU is dangerous offensively, Iowa State’s physical perimeter defense disrupts rhythm and limits clean three-point looks. BYU recently lost their second best player for the season in Richie Saunders to a torn ACL. FanDuel has the best line on this play at -102 odds.

Score prediction: Iowa State 73, BYU 62


🔥 Best Iowa State vs. BYU player prop bet

Tamin Lipsey Over 12.5 Total Points (-125)

Tamin Lipsey is in a strong position to score over 12.5 points against BYU tonight because of his expanding offensive role and the matchup dynamics. As Iowa State’s floor general, Lipsey controls tempo, but he has also become more aggressive looking for his own shot, especially in big games. BYU’s defensive scheme often prioritizes limiting frontcourt touches and perimeter shooters, which can open driving lanes for a crafty guard like Lipsey.

He excels at attacking closeouts, finishing through contact, and getting to the free-throw line, all of which boost scoring consistency. In what projects as a competitive, high-possession game, the opportunities should be there. If BYU focuses on slowing Iowa State’s top scoring options, Lipsey will be asked to step up offensively. With his minutes secure and the ball in his hands late, surpassing 12.5 points is well within reach tonight. The best price for this prop bet is -125 via DraftKings, but there's value up to -145.


🚀 Iowa State vs. BYU same-game parlay

I expect a big performance from Iowa State, specifically guard Tamin Lipsey. If he is able to command the offense the way he’s capable of, he should have no problem going over his 12.5-point total, helping Iowa State cover the spread. Meanwhile, Iowa State’s defense should help push this game toward the under.

💵 Iowa State vs. BYU SGP picks

  • Iowa State -3.5 (-102)
  • Under 154.5 (-110)
  • Tamin Lipsey Over 12.5 Total Points (-125)

Best odds: +505 via FanDuel (0.1u -> 0.5.05u)


💡 How I'm betting Iowa State vs. BYU

Follow all of our college basketball analysis and expert predictions this season.

I have 2.2 units between three different angles for Saturday’s Iowa State vs. BYU clash. That is in line with a typical bankroll for a game I’ve broken down in detail.

My main play is going to be the Iowa State -3.5 line here, but I do expect all-three plays to cash. 

📈 Sports betting how-to: Bankroll management

I break down the do's and don’ts of bankroll management.


📊 Live Iowa State vs. BYU odds

The line opened with Iowa State as a 4.5-point favorite but has since moved to 3.5 at most sportsbooks. This slight adjustment suggests some early buyback on the underdog. I expect the number to stabilize and close near its current position, right around the 3.5-point mark by tipoff.


📈 Iowa State vs. BYU betting trends

Iowa State Statistic BYU
23-3 W-L record 19-7
15-10-1 ATS record 11-15
12-14 O/U record 13-13
4-1 Last 5 games 2-3

📺 How to watch Iowa State vs. BYU

  • Date: Saturday, Feb. 21
  • Tipoff: 10:30 p.m. ET
  • Location: Marriott Center (Provo, UT)
  • TV: ESPN

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