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Indiana vs. South Carolina Prediction & Odds: Friday's Women's March Madness Sweet 16

C Jackson Cowart

Last Updated: March 29, 2024 2:48 PM EDT • 2 min 44 sec read.

MiLaysia Fulwiley #12 of the South Carolina Gamecocks celebrates as we offer our best Indiana vs. South Carolina prediction and pick for the Sweet 16 of the women's NCAA Tournament on Friday.
MiLaysia Fulwiley #12 of the South Carolina Gamecocks celebrates her three-point basket against the Presbyterian Blue Hose in the second quarter during the first round of the NCAA Women’s Basketball Tournament at Colonial Life Arena on March 22, 2024 in Columbia, South Carolina. Photo by Eakin Howard/Getty Images via AFP.

The No. 1 South Carolina Gamecocks clash with the No. 4 seed Indiana Hoosiers in the Sweet 16 of the Women's NCAA Tournament, as we offer our best Indiana vs. South Carolina prediction and best bet for the Sweet 16 of March Madness.

The undefeated South Carolina Gamecocks, after securing two comfortable victories in the NCAA Tournament, face a potential challenge against the fourth-seeded Indiana Hoosiers in the Sweet 16 at MVP Arena in Albany, NY. With a 15-point favorite status, the Gamecocks anticipate a competitive matchup scheduled to tip off at 5 p.m. ET on ESPN.

To nobody's surprise, the Gamecocks are dealing as massive favorites across our best sports betting sites, as they remain the clear title favorites by the latest Women's March Madness odds after a perfect season to this point. The Hoosiers will try to conjur some March magic to end that unblemished run and keep their own title hopes alive on Friday.

As part of our March Madness predictions, here is our best Indiana vs. South Carolina prediction; don't miss our Gonzaga vs. Texas prediction for Friday (odds via our best March Madness betting sites; pick confidence based on a 1-to-5-star scale).

Indiana (4) vs. South Carolina (1) game info

  • When: Friday, March 29
  • Tip-off: 5 p.m. ET
  • Where: MVP Arena, Albany, N.Y.
  • How to watch: ESPN
  • Favorite: South Carolina -15 (-110 via Caesars)

Indiana vs. South Carolina odds

TeamsMoneylineSpreadTotal
South Carolina-2000-15 (-110)Over: 144.5 (-110)
Indiana+1050+15 (-110)Under: 144.5 (-110)

Indiana vs. South Carolina prediction

South Carolina -15 ⭐⭐⭐⭐

Best odds: -110 via Caesars

At this point in the season, the question is no longer whether South Carolina will win its upcoming game. It's by how much.

Our best sportsbooks are expecting another blowout for Dawn Staley's group, which won its first two games by a combined 99 points to secure a spot in the Sweet 16. Those two wins were among 25 victories by at least 15 through the Gamecocks' first 34 games, with three of those coming against ranked opponents.

Indiana is no slouch, having already beaten Iowa and Tennessee earlier this season. But it was also trounced by Stanford in a 96-64 loss back in November, when star big Cameron Brink dropped 20 points and 17 rebounds for the Cardinal. That doesn't bode well for the Hoosiers' chances of slowing this deep and versatile South Carolina frontcourt.

The X-factor in this matchup is freshman guard MiLaysia Fulwiley, who has come on late in the year with seven double-digit scoring efforts in her last eight games. She finished with 20 points, nine rebounds, and four steals in Sunday's 88-41 win over UNC, and she could have a field day against an Indiana defense ranked 135th in opponent efficiency.

In addition to the on-court mismatches, the Gamecocks enjoy an extra day of rest ahead of this game and have the depth, talent, and coaching to take advantage. Expect another big win on Friday for the tournament favorites.

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Indiana vs. South Carolina spread & Over/Under analysis

Most of our best sports betting apps have South Carolina dealing as a favorite between 15.5 and 16.5 point ahead of its matchup with Indiana in the Sweet 16 on Friday. That's what makes this -15 price so compelling at Caesars, which doesn't often have the best odds but is good for an outlier now and then.

There's much more consensus on the total, which sits at 144.5 across all of our best sportsbooks. Without much variety in the market, I'd highly recommend checking out our best sportsbook promos to see which book is offering the best bonus for this game and the rest of March Madness.

Indiana-South Carolina prediction made Wednesday at 6:30 p.m. ET.

Here are our best March Madness betting sites:

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* Bonuses not applicable in Ontario.

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Written By:
C Jackson Cowart
C Jackson Cowart is an award-winning sports writer, reporter, and editor with nearly a decade of experience in the industry, with previous stops at theScore, Action Network, Forbes, and ESPN before joining the Sportsbook Review team. He's written about sports betting for the last five years, with a specialty in NFL, NBA, MLB, and collegiate futures markets and a weakness for novelty props and betting on the eventual runner-up. He's also an avid fantasy sports manager and commissioner and runs a sports card business on the side. He's a fiercely proud Oregon native and UNC alumnus, and he can't seem to stop betting on Ben Simmons to win MVP.