Clemson vs. Duke Prediction, Picks & Odds: College Basketball Picks Today (Feb. 14)

My Clemson vs. Duke prediction backs the Tigers (+12.5) given their road success dating back to last season.
Duke Blue Devils forward Cameron Boozer (12) grabs the rebound as we break down our Clemson vs. Duke prediction, picks & odds.
Pictured: Duke Blue Devils forward Cameron Boozer (12) grabs the rebound as we break down our Clemson vs. Duke prediction, picks & odds. Photo by Bob Donnan-Imagn Images
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No. 20 Clemson would move into a tie for first place in the ACC if it upsets No. 4 Duke as I make my Clemson vs. Duke prediction. Tipoff from Cameron Indoor Stadium in Durham, N.C. is set for noon ET (ESPN).  

Duke is a 12.5-point betting favorite against a Tigers squad that just had a four-game winning streak snapped with a 10-point home loss to Virginia Tech. But I am still backing Clemson as road underdogs given how successful it has been against the Blue Devils in recent seasons.


🏀 Clemson vs. Duke predictions

See our experts' college basketball picks based on the latest college basketball odds.

Prediction Best odds Confidence
Clemson +13.5 -115 via bet365 ⭐⭐⭐⭐
Over 133.5 -110 via FanDuel ⭐⭐⭐
Isaiah Evans Under 13.5 points +100 via FanDuel ⭐⭐⭐

💰 Clemson vs. Duke best bet: Clemson +13.5 (-105) 

Check out all of our college basketball analysis and expert predictions this season.

Brad Brownell’s Tigers have beaten Duke in two of the last three seasons, while the Blue Devils last two home wins against Clemson have been by three combined points. 

Clemson has won 14 straight ACC road games, the second longest streak in conference history. The Tigers’ 15-1 (.938) road record in conference play dating back to last season is also an ACC best, so they won’t be intimidated by the Cameron Crazies. 

This four-star Clemson vs. Duke best bet backs the Tigers to improve to 3-0 ATS as an underdog and 3-0-1 ATS against ranked opponents this season.

Score prediction: Duke 74, Clemson 63


🔥 Best Clemson vs. Duke player prop: Isaiah Evans, Duke, Under 13.5 points (+100) 

Duke’s Isaiah Evans is coming off a 21-point effort against Pittsburgh on an efficient 8-for-10 shooting, while his five 3-pointers were his second most all season. But Clemson has forced three heavily transition-reliant offenses in BYU, SMU, and NC State into half-court grinds, and that lowers the ceiling for Evans’ point total considerably.

Evans has only topped 12 points once in the last four games, and Cameron Boozer and his lofty O/U of 21.5 points should again make up the brunt of Duke’s scoring.


📊 Live Clemson vs. Duke odds


📈 Clemson vs. Duke betting trends

Clemson Statistic Duke
20-5 W-L record 22-2
15-10 ATS record 13-11
10-15 O/U record 7-17
4-1 Last 5 games 4-1

📺 How to watch Clemson vs. Duke

  • Date: Saturday, Feb. 14
  • Tipoff: Noon ET
  • Location: Cameron Indoor Stadium (Durham, N.C.)
  • TV: ESPN

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