Reds vs. Dodgers Prediction, Odds & Best Bets: Ohtani To Get Hot at Home

Hunter Greene, who appears to be in perfect midseason form, forms the backbone of our Reds vs. Dodgers prediction for tonight's late contest.

Mike Spector

Last Updated: August 25, 2025 9:00 AM EDT • 4 minute read

Pictured: Shohei Ohtani reacts on a play against the Colorado Rockies as we offer our Isaiah J. Downing-Imagn Images

The Cincinnati Reds and Los Angeles Dodgers look to strike first in this series opener after avoiding sweeps against NL West opponents with wins on Sunday.

My Reds vs. Dodgers prediction backs Cincinnati as +120 moneyline underdogs at our best sports betting sites behind ace Hunter Greene, who looks to be rounding into midseason form.

This is the latest start time on Monday’s slate, with first pitch from Dodger Stadium set for 10:10 p.m. ET (MLBN).

Though he did not perform well in the last series, my Reds vs. Dodgers best bets back one of Shohei Ohtani’s player props, hoping a return home gets his bat going.

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✅ Reds vs. Dodgers prediction: Reds to win (+120 via BetMGM)

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Following a 10-week IL stint, Greene has looked in perfect midseason form. He has pitched to a 2.19 ERA in back-to-back quality starts, one of which came against the division-leading Philadelphia Phillies.

More importantly, Cincinnati won both of those starts and has a plus-10 run differential in Greene’s last three outings, which is why this has great value as my Reds vs. Dodgers prediction.

The Dodgers tied a season-low with two hits in Saturday’s loss to the San Diego Padres.

Some may give Los Angeles a pass for its poor offensive effort in the Padres series (San Diego’s starters combined for three earned runs in 18 innings), considering San Diego had pitched to a 2.29 ERA and .171 OBA from August 10-23.

But the hard-throwing Greene is precisely the type of pitcher who should add to the Dodgers’ offensive woes.

This is a confident Reds vs. Dodgers best bet as Los Angeles has covered the run line in fewer than 40% of its games as home favorites and is just 49-46 overall in non-division games.

BetMGM’s +120 odds are aligned with several other best sports betting apps on the best price for Reds backers, and a $10 winning wager would return $12 in profits.

📊 Live Reds vs. Dodgers odds: Monday, 10:10 p.m. ET

💰 Best Reds vs. Dodgers player prop

✅ Best Reds vs. Dodgers player prop: Shohei Ohtani Over 1.5 total bases (+100 via bet365)

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Ohtani had his 19-game on-base streak snapped in Saturday’s loss to the Padres. But I am buying low on the Los Angeles slugger with my best Reds vs. Dodgers player prop, as he hasn't hit well historically at Petco Park.

In 18 career road games against San Diego, Ohtani has batted .148 with a .615 OPS. But he hit a home run in his final at-bat yesterday, which has me confident despite him going 1-for-5 in his career against Greene.

Greene’s slugging percentage allowed is 101 points higher to left-handed batters than righties, and he has shown some vulnerability with a 3.66 ERA in six road starts.

bet365 is the only one of our best sportsbooks where one can back the Over at plus-money odds.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”