Red Sox vs. Yankees Predictions, Odds & Best Bets: Expect Fireworks Between AL East Rivals

We're anticipating a high-scoring affair when Boston and New York meet on Thursday night.

Josh Goldberg

Last Updated: August 21, 2025 10:45 AM EDT • 4 minute read

Red Sox vs. Yankees Predictions, Odds & Best Bets: Thursday, Aug. 21 — Pictured: New York's Aaron Judge (99) as we break down our Red Sox vs. Yankees prediction. Photo by Jeff Curry via Imagn Images.

The New York Yankees welcome their hated rivals, the Boston Red Sox, to Yankee Stadium for the first of a four-game series, and we’re breaking it down with our Red Sox vs. Yankees prediction. First pitch is set to fly at 7:15 p.m. ET on Thursday (FOX).

I like the teams to go Over the total of eight runs in the series opener, a number they’ve soared past in 50% of their previous six matchups so far this season.

The Yankees are red-hot, winning five straight games while averaging 8.6 runs per game. Yankees slugger Aaron Judge has a .988 OPS against Boston this season and matches up well against Red Sox pitcher Lucas Giolito for our Red Sox vs. Yankees best bets. New York is favored to win at -140 odds at the best sports betting sites.

⚾ Red Sox vs. Yankees prediction & odds

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💰 Red Sox vs. Yankees prediction & best bet

✅ Red Sox vs. Yankees prediction: Over 8 runs (-110 via BET99)

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Both the Yankees and Red Sox rank inside the top five among all MLB teams in runs scored this season. The Yankees also lead the league in home runs and OPS, while the Red Sox are 11th and seventh in those two categories, respectively. Yankee Stadium also ranks among the league’s most favorable venues for home runs as we make our Red Sox vs. Yankees best bet.

Yankees right-hander Luis Gil has been rusty in three starts after missing the first four months of the season with a lat injury. Gil has a 5.14 ERA, 1.64 WHIP, and eight walks across 14 innings. Giolito, meanwhile, has posted a 4.85 ERA and allowed five home runs in five career starts against the Yankees. This game has all the makings of an offensive bonanza.

📊 Live Red Sox vs. Yankees odds: Thursday, 7:15 p.m. ET

💰 Best Red Sox vs. Yankees player prop

✅ Best Red Sox vs. Yankees player prop: Aaron Judge Over 0.5 RBIs (+130 via DraftKings)

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Judge has had a relatively quiet month of August by his lofty standards, slashing .227/.414/.455 with seven home runs and 14 RBIs in 13 games since returning from a stint on the IL. The slugger’s prodigious power looks like a great fit against Giolito, who’s allowed 1.27 HR/9 this season. This looks like a great spot for Judge to do damage as we try to capitalize with our best Red Sox vs. Yankees player prop.

Judge has destroyed fastballs this season with a .415 batting average, .892 slugging percentage, and 28 home runs. Giolito’s fastball has given him trouble at times this season, and he owns an expected ERA of 5.27, which sits in the 12th percentile among MLB pitchers.

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❓MLB betting FAQs

Who is the favorite to win Red Sox vs. Yankees?

The Yankees are favored vs. the Red Sox at -140 odds, giving New York an implied 58.33% win probability, according to our odds converter.

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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Written by:
Josh Goldberg

Josh is a sports writer, editor, host, and producer from Toronto, Ontario. Before joining Sportsbookreview.com, Josh spent over a decade covering Major League Baseball and the Toronto Blue Jays for Sportsnet 590 The Fan and theScore in Toronto. He also hosts a weekly Toronto Blue Jays podcast called Designated for Assignment. Josh has been betting for over a decade and is active in the prop markets for MLB, the NFL, NBA, and NHL. He hit a six-leg touchdown parlay about a decade ago, solidifying his love for betting props. Josh also subscribes to the importance of betting with the most information available and trying to stay consistent with the number of units he allocates for each wager. At the end of the day, it's important to find a way to continue having fun while also being informed and responsible when laying a bet.