Giants vs. Padres Prediction, Odds & Best Bets: San Diego Primed to Rock Roupp

It will be a tough matchup for San Francisco pitcher Landen Roupp against the Padres' balanced lineup.

Josh Goldberg

Last Updated: August 20, 2025 11:41 AM EDT • 4 minute read

Giants vs. Padres Predictions, Odds & Best Bets: Wednesday, Aug. 20 — Pictured: San Diego third baseman Manny Machado (13) is congratulated by Xander Bogaerts (2) as we make our Giants vs. Padres prediction. Photo by Denis Poroy via Imagn Images.

The San Diego Padres look to take advantage in the third game of a four-game series with the San Francisco Giants tonight, and we're breaking it down with our Padres vs. Giants prediction. First pitch is set to fly from Petco Park at 9:40 p.m. ET on Wednesday (NBCSBA, SDPA, MLB Network).

I like the Padres on the moneyline against a Giants pitcher still rounding into form after missing time due to injury. The Padres have won more than 60% of games as moneyline favorites this season and match up well with Landen Roupp for our Giants vs. Padres best bets.

San Diego is favored at -144 odds to win at our best sports betting sites.

⚾ Giants vs. Padres prediction & odds

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💰 Giants vs. Padres prediction & best bet

✅ Giants vs. Padres prediction: Padres to win (-144 via Pinnacle)

The Padres are locked in a tight battle as they try to chase down the top spot in the National League West.

Left-hander JP Sears draws the start for the Padres and should have an advantage against San Francisco as we make our Giants vs. Padres best bet. Giants hitters have struggled against lefty pitching this year, ranking 30th in batting average and OPS against southpaws. This profiles as a strong spot for Sears and the Padres to have success on Wednesday night.

The Padres have as high as a 61.98% implied probability to win based on -163 odds at BetVictor. Our -144 on the moneyline at Pinnacle looks like a great number in comparison among the best sports betting apps.

📊 Live Giants vs. Padres odds: Wednesday, 9:40 p.m. ET

💰 Best Giants vs. Padres player prop

✅ Best Giants vs. Padres player prop: Landen Roupp Under 3.5 strikeouts (+105 via Caesars)

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Roupp struggled in his first start after missing more than three weeks due to right elbow inflammation, lasting just three innings with five earned runs on five hits. He threw only 66 pitches, leading to questions about how long he’ll be able to go against San Diego as we look to take advantage in our Giants vs. Padres best player prop.

Roupp has been worse on the road this season, registering a 4.15 ERA with 27 walks in 56 1/3 innings.

The Padres own MLB’s second-best strikeout rate this season at 18.5%. San Diego’s ability to limit strikeouts, draw walks, and make contact should line up nicely to limit Roupp’s effectiveness.

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❓MLB betting FAQs

Who is the favorite to win Giants vs. Padres?

The Padres are favored vs. the Giants at -144 odds, giving San Diego an implied 59.02% win probability, according to our odds converter.

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.

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Written by:
Josh Goldberg

Josh is a sports writer, editor, host, and producer from Toronto, Ontario. Before joining Sportsbookreview.com, Josh spent over a decade covering Major League Baseball and the Toronto Blue Jays for Sportsnet 590 The Fan and theScore in Toronto. He also hosts a weekly Toronto Blue Jays podcast called Designated for Assignment. Josh has been betting for over a decade and is active in the prop markets for MLB, the NFL, NBA, and NHL. He hit a six-leg touchdown parlay about a decade ago, solidifying his love for betting props. Josh also subscribes to the importance of betting with the most information available and trying to stay consistent with the number of units he allocates for each wager. At the end of the day, it's important to find a way to continue having fun while also being informed and responsible when laying a bet.