Cardinals vs. Diamondbacks Prediction, Odds & Best Bets: Will Cards’ Road Struggles Continue?

St. Louis has been woeful away from Busch Stadium this season. Will those woes continue tonight in Arizona?

Mike Spector

Last Updated: July 19, 2025 10:03 AM EDT • 4 minute read

Cardinals vs. Diamondbacks Prediction, Odds & Best Bets: Saturday, July 19 — Pictured: Arizona Diamondbacks third baseman Eugenio Suarez (28) celebrates after hitting a solo home run as we make our Cardinals vs. Diamondbacks prediction. Photo by Jayne Kamin-Oncea via Imagn Images.

The St. Louis Cardinals (51-47) look to even this three-game series with the Arizona Diamondbacks (48-50), as I make my Cardinals vs. Diamondbacks prediction. First pitch from Chase Field in Phoenix is set for 7:15 p.m. ET (FOX).

It remains unclear whether or not Arizona will be sellers at the trade deadline, but regardless, we are backing one of its most coveted sluggers with my Cardinals vs. Diamondbacks best bets.

Cardinals vs. Diamondbacks prediction: Diamondbacks to win (+100 via FanDuel) ⭐⭐⭐
Best Cardinals vs. Diamondbacks player props: Eugenio Suarez Over 0.5 RBIs (+180 via bet365) ⭐⭐⭐⭐

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✅ Cardinals vs. Diamondbacks prediction: Diamondbacks to win (+100 via FanDuel)

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Much of Arizona’s future rides on what happens in the next two weeks, as the team is likely one more cold spell away from its front office deciding to punt this season and build for the future. But that is also the sort of thing that can galvanize a team, and that motivation is a big part of my Cardinals vs. Diamondbacks prediction.

Arizona has been one of the teams hardest hit by injuries, with both Corbin Carroll and Ketel Marte missing significant time this season. That makes it even more impressive that the Diamondbacks' run differential is only four runs worse than St. Louis’, despite playing in one of two divisions to feature three teams with at least 52 wins.

The ceiling remains high for Arizona’s offense as long as Carroll can get going. I expect nothing but positive regression for the table setter who is batting .059 with 16 strikeouts in nine games since returning from the IL.

My Cardinals vs. Diamondbacks best bet is heavily predicated on Arizona righty Ryne Nelson’s success at home (4-1, 2.17 ERA) compared to his road starts (1.1, 5.79 ERA). In addition, the Diamondbacks are one of two MLB teams Cardinals righty Sonny Gray has never beaten in his career, while St. Louis has lost four of its last six road series.

Dustin Saracini displays his confidence in both Gray and Nelson by making this game one of the best NRFI bets today.

💰 Best Cardinals vs. Diamondbacks player props

✅ Best Cardinals vs. Diamondbacks player prop: Eugenio Suarez Over 0.5 RBIs (+180 via bet365)

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Eugenio Suarez’s numbers from the start of July last season to yesterday’s series opener are eye-popping. In that span, Suarez ranked fourth in home runs (55), first in RBIs (147), fourth in slugging (.591, min. 250 PA), 12th in wRC+ (151, min. 250 PA), and 10th in fWAR (6.6).

Suarez is second in the league with 78 RBIs, and he has the highest career batting average of any current Diamondbacks hitter against Gray (.455, 5-for-11).

I was tempted to tail Gabe Henderson's best home run predictions today and pick Suarez to hit a home run as my best Cardinals vs. Diamondbacks player prop, but Gray has allowed a 0.8 HR/9 rate and is two years removed from leading the league in that metric. However, the value on him to record an RBI at bet365 is striking.

A winning $10 wager would return $18 in profits, compared to $14.50 based on DraftKings’ odds (+145), which are on the low end of the market.

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❓MLB betting FAQs

How do betting odds work?

Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.

What is the run line in baseball?

The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.

What does moneyline mean in betting?

The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet—just pick the winner.

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Written by:
Mike Spector

Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”