Brewers vs. Cubs Prediction, Odds & Best Bets: Misiorowski to Bounce Back for Milwaukee

Last Updated: August 20, 2025 10:46 AM EDT • 4 minute read X Social Google News Link

The Milwaukee Brewers (79-47) are looking to bounce back after losing both games of yesterday’s doubleheader to the Chicago Cubs (72-54) as we make our Brewers vs. Cubs prediction for Wednesday night.
Tuesday was the first time Milwaukee looked mortal in several weeks. Speaking of which, the once NL Rookie of the Year favorite, Jacob Misiorowski, got knocked around in his first start back from the injured list last week. He gave up five runs on four hits in 1 1/3 innings against the Cincinnati Reds last Friday.
We believe in a bounce-back effort from Misiorowski and Milwaukee. First pitch is set for 8:05 p.m. ET (FDSN, Marquee Sports Network) on Wednesday at Wrigley Field, with the Brewers favored at -115 odds to win at the best sports betting sites.
⚾ Brewers vs. Cubs prediction & odds
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💰 Brewers vs. Cubs prediction & best bet
✅ Brewers vs. Cubs prediction: Brewers to win (-115 via BetMGM)
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Projections favor the Cubs, with Ballpark Pal giving them a 51.6% chance of victory. However, I don’t think it’s possible to properly quantify which version of Misiorowski we will see for our Brewers vs. Cubs prediction.
It’d be easy to suggest that Misiorowski was rusty in his first start back, as he threw 25 of his 54 pitches out of the strike zone. After the game, he hinted at some of his frustrations with the mound at Great American Ball Park, specifically his landing spot. That’s extremely important for a pitcher with his 6-foot-7 frame (99th percentile in extension).
As a result, Misiorowski is likely being underrated in the betting market. That seemed impossible to imagine earlier this summer when he was a minus-odds favorite to win NL Rookie of the Year and the biggest story in the league.
I’ll scoop up the potential discount for my Brewers vs. Cubs best bet.
📊 Live Brewers vs. Cubs odds: Wednesday, 8:05 p.m. ET

💰 Best Brewers vs. Cubs player prop
✅ Best Brewers vs. Cubs player prop: Owen Caissie Under 0.5 hits (-110 via Caesars)
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Caissie, the Cubs’ top prospect, hit his first career home run during the nightcap of yesterday’s doubleheader. That provides us a chance to fade him in our Brewers vs. Cubs player prop, considering he had one hit in his first eight at-bats entering Tuesday’s twin bill.
Not only could getting a hit off Misiorowski prove to be difficult, but Caissie is a pinch-hit risk after being subbed out of a game yesterday. That helps provide some extra value on the Under at -110 or better at the best MLB betting sites.
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❓MLB betting FAQs
Who is the favorite to win Brewers vs. Cubs?
The Brewers are favored vs. the Cubs at -115 odds, giving Milwaukee an implied 53.49% win probability, according to our odds converter.
How do betting odds work?
Betting odds represent the probability of a specific outcome and determine how much money you can win on a bet. There are three main formats: American odds, Decimal odds, and Fractional odds. In the U.S., American odds are most common.
What is the run line in baseball?
The run line in baseball is a form of point spread betting unique to MLB. It typically sets a standard spread of 1.5 runs, meaning the favored team must win by at least two runs to cover the run line, while the underdog can lose by one run or win outright to cover.
What does moneyline mean in betting?
The moneyline in betting refers to a wager on which team or player will win the game outright, with no point spread involved. It’s the most straightforward type of sports bet - just pick the winner.
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