Best NRFI Bets Today: No Run First Inning Picks For Tuesday, July 22

Misiorowski and Yamamoto highlight our best NRFI bets today. Can we build on our 52-34 record?

Last Updated: July 22, 2025 2:18 PM EDT • 4 minute read

Best NRFI Bets Today - Tuesday, July 22 — Jacob Misiorowski - who highlights our best NRFI bets today - of the Milwaukee Brewers pitches during the eighth inning. Photo by: Dale Zanine-Imagn Images

Welcome to our best NRFI bets today for Tuesday, July 22.

We said we would hit on six sweat-free outs yesterday, and that's exactly what we did in both games. Let's keep the momentum going on our trek to the moon during this fine Tuesday.

We're now sitting at 52-34 on the campaign with 9.00 extra units in our pocket. Our collective bankroll is getting fat as the season rolls along. It's time to get into my first-inning picks and predictions using odds from our best sports betting sites.

All of these plays are one-unit wagers unless specified otherwise.

💰 Best NRFI picks today: Tuesday, July 22

Milwaukee Brewers vs. Seattle Mariners (-164 at FanDuel)
Minnesota Twins vs. Los Angeles Dodgers (-110 at DraftKings)

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⚾️ Brewers vs. Mariners - 9:40 p.m. ET

Jacob Misiorowski (2.81 ERA) vs. Logan Gilbert (3.39 ERA)
NRFI record: Brewers (58-42) vs. Mariners (50-50)

Fresh off a NRFI win in this specific matchup, we're coming back to the well with two stud pitchers who shouldn't struggle to get through the first frame unscathed.

Gilbert will kick this play off in style, as two of the projected top-three hitters for the Brewers are 0-for-7 against him lifetime. If he can get past Christian Yelich, who typically rakes versus the right-hander (3-for-6, two home runs), we should be in the clear for this play to hit as part of our best NRFI bets today.

Misiorowski - the NL Rookie of the Year odds favorite - will bring us home against the Mariners, who have yet to take an at-bat against him.

The rookie was dialed in against the Dodgers during his last start before the All-Star break, allowing just one earned run across six innings. He's been one of the best pitchers in baseball since his call-up, and I don't envision Seattle posing much of a threat in the first frame. Let's ride this one with confidence.

Confidence level: ⭐⭐⭐⭐

Best NRFI bets today: -164 at FanDuel

⚾️ Twins vs. Dodgers - 10:10 p.m. ET

Simeon Woods-Richardson (3.95 ERA) vs. Yoshinobu Yamamoto (2.59 ERA)
NRFI record: Twins (48-52) vs. Dodgers (46-55)

We're receiving -110 betting odds with Yamamoto on the mound? I'll take that every time. I'd price this closer to -130 with the Dodgers ace starting and his offense reeling on the other side.

Woods-Richardson is quietly one of the hottest pitchers in the big leagues right now, too, after allowing just two earned runs across his last 19 2/3 innings. I hold the utmost confidence in him to get us three outs. While Shohei Ohtani will generally always be Ohtani in the leadoff spot, Mookie Betts is in the midst of his worst career stretch at the plate.

Don't get me wrong, it's always difficult to bet against this Dodgers offense, which is why we have them winning as part of our best Twins vs. Dodgers predictions. But if you're going to do it during a 162-game season, now is the time with our best NRFI bets today.

Confidence level: ⭐⭐⭐⭐

Best NRFI bets today: -110 at DraftKings

💡 Expert MLB predictions today

❓ Best NRFI bets today FAQs

What is a NRFI bet?

A NRFI bet is a wager on a matchup to go scoreless in the first inning. You can either wager “No Runs First Inning” or “Yes Runs First Inning” depending on the type of bet you'd like to make.

How do I place a NRFI bet?

To place a NRFI bet, simply go to one of our best sportsbooks, head over to the market and your game of choice. Then click on “first inning.” You should see an option to bet on a NRFI or a YRFI.

Can you parlay a NRFI bet?

The simple answer is yes! Just like making any parlay, you can combine two or more NRFIs across the MLB slate for any given day.

💵 Best MLB betting sites

Want to bet on baseball? Check out the best MLB betting sites and best sportsbook promos for today's games:

FanDuel Promo Code | Read our FanDuel Review
DraftKings Promo Code | Read our DraftKings Review
Hard Rock Bet Promo Code | Read our Hard Rock Bet Review

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* Bonuses not applicable in Ontario.

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Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.

Written by:
Dustin Saracini

Dustin Saracini is a Senior Publishing Editor & Analyst for Sportsbook Review. Dustin has been in the industry for 11-plus years, making various stops across Canada while gaining tremendous experience within the sports and betting landscape. Dustin has hosted multiple shows during his time in the sports betting industry, discussing NBA, NFL, PGA, and MLB betting markets with top handicappers from around the country, and has appeared on CNN as a betting consultant. Dustin wagers every single day and line shops at all of the top sportsbooks (FanDuel, DraftKings, BetMGM, and Caesars). He firmly believes that discipline is the only way you can become a profitable bettor. Dustin graduated from Western University with a broadcast journalism degree/diploma in 2014. If you want to see more of his plays, make sure to follow his Twitter @DustinSaracini. Follow for picks, strategies, and more.